[ { "nctId": "NCT07703137", "title": "NAD Supplementation in Parkinson's Disease", "status": "ENROLLING_BY_INVITATION", "phases": [ "NA" ], "sponsor": "University of Oklahoma", "sponsorKey": "university of oklahoma", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson's Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-08-10", "primaryCompletionDate": "2027-07", "lastUpdateDate": "2026-08-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [ { "field": "status", "fromValue": "NOT_YET_RECRUITING", "toValue": "ENROLLING_BY_INVITATION", "detectedAt": "2026-08-13T05:00:32.413Z" }, { "field": "start_date", "fromValue": "2026-07", "toValue": "2026-08-10", "detectedAt": "2026-08-13T05:00:32.413Z" }, { "field": "primary_completion_date", "fromValue": "2027-06", "toValue": "2027-07", "detectedAt": "2026-08-13T05:00:32.413Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT07703137" }, { "nctId": "NCT07741071", "title": "N-AD: Orally Administered Nicotinamide Riboside Over Two Years as a Potential Disease Modifying Treatment for Alzheimer's Disease", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease (AD)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-08-15", "primaryCompletionDate": "2030-04-30", "lastUpdateDate": "2026-08-12", "firstSeenAt": "2026-08-04T05:00:19.366Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07741071" }, { "nctId": "NCT06877572", "title": "Weight Loss Management in Endometrial Cancer Survivors", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "University of Kansas Medical Center", "sponsorKey": "university of kansas medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Endometrial Cancer Survivors", "Weight Management", "Early Stage Endometrial Cancer" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-03-25", "primaryCompletionDate": "2028-10", "lastUpdateDate": "2026-08-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [ { "field": "status", "fromValue": "RECRUITING", "toValue": "ACTIVE_NOT_RECRUITING", "detectedAt": "2026-08-13T05:00:32.413Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT06877572" }, { "nctId": "NCT07760948", "title": "HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Vanderbilt University Medical Center", "sponsorKey": "vanderbilt university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes Mellitus (T2DM)", "Sarcopenia", "Obesity", "Muscle Loss", "Older Adults" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-12-01", "primaryCompletionDate": "2029-11-30", "lastUpdateDate": "2026-08-12", "firstSeenAt": "2026-08-13T05:00:32.413Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07760948" }, { "nctId": "NCT07760532", "title": "Comparing Facial Aging Between Identical Twins With 3D Imaging", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Ponsky Facial Aesthetics And Plastic Surgery", "sponsorKey": "ponsky facial aesthetics and plastic surgery", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Facial Skin Aging", "Facial Volume Loss", "Wrinkle Appearance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-08-08", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2026-08-12", "firstSeenAt": "2026-08-13T05:00:32.413Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07760532" }, { "nctId": "NCT04098666", "title": "Metformin in Alzheimer's Dementia Prevention", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Columbia University", "sponsorKey": "columbia university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2021-03-22", "primaryCompletionDate": "2026-04-23", "lastUpdateDate": "2026-08-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04098666" }, { "nctId": "NCT05561738", "title": "Nicotinamide Riboside in Ulcerative Colitis", "status": "TERMINATED", "phases": [ "NA" ], "sponsor": "University of Pittsburgh", "sponsorKey": "university of pittsburgh", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ulcerative Colitis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-02-28", "primaryCompletionDate": "2026-06-30", "lastUpdateDate": "2026-08-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [ { "field": "status", "fromValue": "RECRUITING", "toValue": "TERMINATED", "detectedAt": "2026-08-11T05:00:20.374Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT05561738" }, { "nctId": "NCT05835999", "title": "Everolimus Aging Study", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "University of Wisconsin, Madison", "sponsorKey": "university of wisconsin, madison", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Insulin Resistance" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2023-03-24", "primaryCompletionDate": "2026-06-30", "lastUpdateDate": "2026-08-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [ { "field": "status", "fromValue": "ACTIVE_NOT_RECRUITING", "toValue": "COMPLETED", "detectedAt": "2026-08-11T05:00:20.374Z" }, { "field": "primary_completion_date", "fromValue": "2026-09", "toValue": "2026-06-30", "detectedAt": "2026-08-11T05:00:20.374Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT05835999" }, { "nctId": "NCT04332341", "title": "Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Case Comprehensive Cancer Center", "sponsorKey": "case comprehensive cancer center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Allogeneic Hematopoietic Cell Transplantation" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-05-19", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2026-08-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04332341" }, { "nctId": "NCT07317934", "title": "Efficacy and Safety of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (STELLAR)", "status": "RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Innostellar Biotherapeutics", "sponsorKey": "innostellar biotherapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)", "Wet AMD" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2026-01-14", "primaryCompletionDate": "2028-03", "lastUpdateDate": "2026-08-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07317934" }, { "nctId": "NCT07504744", "title": "Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute Coronary Syndrome", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Meenakshi Ammal Dental College and Hospital", "sponsorKey": "meenakshi ammal dental college and hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Periodontal Diseases", "Acute Coronary Artery Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-08-05", "primaryCompletionDate": "2026-10-03", "lastUpdateDate": "2026-08-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07504744" }, { "nctId": "NCT05210803", "title": "Long-Term Follow-Up Study of RGX-314 Administered in the Suprachoroidal Space for Participants With nAMD", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE2" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2021-12-20", "primaryCompletionDate": "2031-07", "lastUpdateDate": "2026-08-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [ { "field": "phase", "fromValue": null, "toValue": "PHASE2", "detectedAt": "2026-08-06T05:00:54.408Z" }, { "field": "primary_completion_date", "fromValue": "2028-03", "toValue": "2031-07", "detectedAt": "2026-08-06T05:00:54.408Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT05210803" }, { "nctId": "NCT07630649", "title": "Ixoberogene Soroparvovec (Ixo-vec) Contralateral Dosing Study in Participants With Neovascular Age-related Macular Degeneration", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD) Wet AMD" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2026-06-02", "primaryCompletionDate": "2031-06", "lastUpdateDate": "2026-08-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07630649" }, { "nctId": "NCT07747805", "title": "GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "The Cleveland Clinic", "sponsorKey": "the cleveland clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "COPD", "Obesity & Overweight", "Sarcopenia" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-08-28", "primaryCompletionDate": "2028-08-15", "lastUpdateDate": "2026-08-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07747805" }, { "nctId": "NCT05407636", "title": "Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "AMD", "nAMD", "Wet Age-related Macular Degeneration", "wAMD", "WetAMD", "CNV" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2022-01-13", "primaryCompletionDate": "2026-10", "lastUpdateDate": "2026-08-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [ { "field": "status", "fromValue": "RECRUITING", "toValue": "ACTIVE_NOT_RECRUITING", "detectedAt": "2026-08-04T05:00:19.366Z" } ], "nctUrl": "https://clinicaltrials.gov/study/NCT05407636" }, { "nctId": "NCT07007065", "title": "Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)", "status": "RECRUITING", "phases": [ "PHASE3" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-11-05", "primaryCompletionDate": "2033-03", "lastUpdateDate": "2026-08-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07007065" }, { "nctId": "NCT07428746", "title": "Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes", "status": "RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Emory University", "sponsorKey": "emory university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Type 2" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-05-07", "primaryCompletionDate": "2028-11", "lastUpdateDate": "2026-08-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07428746" }, { "nctId": "NCT06032923", "title": "Double-blind Placebo Controlled Study to Evaluate the Effect of NAD+ Boosting With Nicotinamide Riboside on Immunometabolism and Immunity in Systemic Lupus Erythematosus", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Systemic Lupus Erythematosus (Sle)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-03-13", "primaryCompletionDate": "2028-08-01", "lastUpdateDate": "2026-07-31", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06032923" }, { "nctId": "NCT06113016", "title": "Prevention of Frailty With Fisetin and Exercise in Breast Cancer Survivors", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Jonsson Comprehensive Cancer Center", "sponsorKey": "jonsson comprehensive cancer center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anatomic Stage I Breast Cancer American Joint Committee on Cancer (AJCC) v8", "Anatomic Stage II Breast Cancer AJCC v8", "Anatomic Stage III Breast Cancer AJCC v8", "Early Stage Breast Carcinoma" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-07-23", "primaryCompletionDate": "2028-10-31", "lastUpdateDate": "2026-07-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06113016" }, { "nctId": "NCT07645001", "title": "Therapeutic Synergy of Probiotic Augmented Conventional Antidiabetic Pharmacotherapy in Gestational Diabetes Mellitus", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Riphah International University", "sponsorKey": "riphah international university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Gestational Diabetes" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2026-07-29", "primaryCompletionDate": "2027-06", "lastUpdateDate": "2026-07-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07645001" }, { "nctId": "NCT00038727", "title": "Diabetes Prevention Program Outcomes Study", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "sponsorKey": "national institute of diabetes and digestive and kidney diseases (niddk)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus", "Cancer", "CVD" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "1996-07-31", "primaryCompletionDate": "2020-02-28", "lastUpdateDate": "2026-07-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00038727" }, { "nctId": "NCT02363335", "title": "The Role of Phosphodiesterase Inhibitors in Incretin Secretion", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "National Institute on Aging (NIA)", "sponsorKey": "national institute on aging (nia)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Volunteers" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2015-02-13", "primaryCompletionDate": "2016-09-19", "lastUpdateDate": "2026-07-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02363335" }, { "nctId": "NCT06072963", "title": "COMMETS- Combination MCI Metabolic Syndrome", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Rutgers, The State University of New Jersey", "sponsorKey": "rutgers, the state university of new jersey", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease", "Mild Cognitive Impairment", "Metabolic Syndrome" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-01-30", "primaryCompletionDate": "2027-12-01", "lastUpdateDate": "2026-07-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06072963" }, { "nctId": "NCT07702461", "title": "Determination of Resistance Training Status for Patients on Glucagon-Like Peptide-1 Receptor Agonists", "status": "RECRUITING", "phases": [], "sponsor": "Ohio State University", "sponsorKey": "ohio state university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity & Overweight", "Diabetes (DM)" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-06-12", "primaryCompletionDate": "2026-10", "lastUpdateDate": "2026-07-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07702461" }, { "nctId": "NCT07278492", "title": "NAD Augmentation to Prevent or Reverse Alzheimer's Disease in People With Down Syndrome", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Brigham and Women's Hospital", "sponsorKey": "brigham and women's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Down Syndrome (DS)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-08-07", "primaryCompletionDate": "2028-02-29", "lastUpdateDate": "2026-07-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07278492" }, { "nctId": "NCT06381076", "title": "High-protein Oral Supplement With Liposomal Curcumin in Adults Undergoing Hemodialysis.", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "University of Florida", "sponsorKey": "university of florida", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease 5D" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-02-03", "primaryCompletionDate": "2025-05-13", "lastUpdateDate": "2026-07-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06381076" }, { "nctId": "NCT04691986", "title": "Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "VA Office of Research and Development", "sponsorKey": "va office of research and development", "sponsorType": "government", "sponsorClass": "FED", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia", "Nicotinamide Adenine Dinucleotide Concentration", "Muscle Quality and NAD+ Content" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-09-01", "primaryCompletionDate": "2026-03-31", "lastUpdateDate": "2026-07-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04691986" }, { "nctId": "NCT06975111", "title": "Focusing on the Menopausal Transition to Improve Mid-Life Women's Health", "status": "RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "University of Colorado, Denver", "sponsorKey": "university of colorado, denver", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Menopause", "Menopause Hot Flashes", "Menopause Related Conditions", "Cardiovascular" ], "topics": [ "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "metformin", "glp1_aging" ], "startDate": "2026-03-01", "primaryCompletionDate": "2029-10-31", "lastUpdateDate": "2026-07-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06975111" }, { "nctId": "NCT06497595", "title": "Lifestyle Intervention to Reduce the Risk of Sarcopenia in Adults With Diabetes & Obesity Treated With Semaglutide", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Sheba Medical Center", "sponsorKey": "sheba medical center", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes Mellitus in Obese" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-05-11", "primaryCompletionDate": "2027-09-30", "lastUpdateDate": "2026-07-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06497595" }, { "nctId": "NCT07057310", "title": "Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE4" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Menopause" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-05-01", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2026-07-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07057310" }, { "nctId": "NCT07707778", "title": "Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE4" ], "sponsor": "National Taiwan University Clinical Trial Center", "sponsorKey": "national taiwan university clinical trial center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Human Immunodeficiency Virus (HIV)", "Metabolic Dysfunction Associated Steatotic Liver Disease", "Dyslipidaemia", "Diabetes Mellitus", "Obesity & Overweight", "Metabolic Syndrome" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-06-25", "primaryCompletionDate": "2027-12", "lastUpdateDate": "2026-07-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07707778" }, { "nctId": "NCT04903132", "title": "Cellular Senescence and COVID-19 Long-Hauler Syndrome", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "SARS-CoV2 Infection" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-03-01", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-07-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04903132" }, { "nctId": "NCT04785300", "title": "ALSENLITE: Senolytics for Alzheimer's Disease", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment", "Alzheimer Disease" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-07-06", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-07-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04785300" }, { "nctId": "NCT05595499", "title": "Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Jonsson Comprehensive Cancer Center", "sponsorKey": "jonsson comprehensive cancer center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anatomic Stage I Breast Cancer AJCC v8", "Anatomic Stage II Breast Cancer AJCC v8", "Anatomic Stage III Breast Cancer AJCC v8" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-03-27", "primaryCompletionDate": "2027-08-14", "lastUpdateDate": "2026-07-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05595499" }, { "nctId": "NCT07144293", "title": "Improving Physical Ability and Cellular Senescence Elimination in HIV", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsorKey": "national institute of allergy and infectious diseases (niaid)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "HIV", "Frailty", "Prefrail", "Aging Problems" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-12-04", "primaryCompletionDate": "2026-09-01", "lastUpdateDate": "2026-07-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07144293" }, { "nctId": "NCT07693543", "title": "Nicotinamide Riboside Supplementation in Chronic Kidney Disease", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of California, San Diego", "sponsorKey": "university of california, san diego", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-10-01", "primaryCompletionDate": "2028-09-30", "lastUpdateDate": "2026-07-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07693543" }, { "nctId": "NCT07482176", "title": "Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)", "status": "RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)", "Wet AMD" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2026-03-16", "primaryCompletionDate": "2027-11-15", "lastUpdateDate": "2026-07-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07482176" }, { "nctId": "NCT07703215", "title": "NPQ Plus Supplementation for Skin Health and Antioxidant Status", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "N REMEDIER (M) SDN BHD", "sponsorKey": "n remedier (m) sdn bhd", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Eczema", "Atopic Dermatitis", "Skin Health", "Fatigue Symptom", "Sleep Quality", "Antioxidant Capacity", "Oxidative Stress" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-01-01", "primaryCompletionDate": "2026-04-30", "lastUpdateDate": "2026-07-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07703215" }, { "nctId": "NCT07703683", "title": "Myokines as Potential Biomarkers and Drivers of Sarcopenia in Metabolic and Endocrine Diseases", "status": "RECRUITING", "phases": [], "sponsor": "Cliniques universitaires Saint-Luc- Université Catholique de Louvain", "sponsorKey": "cliniques universitaires saint-luc- université catholique de louvain", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes", "Obesity & Overweight", "Cushing Syndrome", "Metabolic Diseases", "Endocrine Diseases", "Sarcopenia", "Sarcopenic Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-02-19", "primaryCompletionDate": "2056-12-31", "lastUpdateDate": "2026-07-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07703683" }, { "nctId": "NCT07569627", "title": "Effects of BFR-training on Stem Cells and Immune Cells in Human Skeletal Muscle", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Taipei", "sponsorKey": "university of taipei", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Exercise", "Blood Flow Restriction (BFR) Training Effects", "Supplement" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-08-01", "primaryCompletionDate": "2025-05-01", "lastUpdateDate": "2026-07-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07569627" }, { "nctId": "NCT07443826", "title": "CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Unlimited Biotechnology", "sponsorKey": "unlimited biotechnology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-related Muscle Decline" ], "topics": [ "Rapamycin", "Gene therapy (longevity)" ], "topicKeys": [ "rapamycin", "gene_therapy" ], "startDate": "2026-06-01", "primaryCompletionDate": "2027-09-30", "lastUpdateDate": "2026-07-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07443826" }, { "nctId": "NCT06995378", "title": "Study EHR Risk Stratification Tools", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of California, Los Angeles", "sponsorKey": "university of california, los angeles", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Prediabetes", "Health Communication", "Patient Comprehension" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2026-05-27", "primaryCompletionDate": "2026-11", "lastUpdateDate": "2026-07-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06995378" }, { "nctId": "NCT07597980", "title": "Lifestyle Intervention to Improve Muscle Function in Older Adults", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Pennington Biomedical Research Center", "sponsorKey": "pennington biomedical research center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Body Composition", "Physical Function", "Energy Balance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-07", "primaryCompletionDate": "2030-12", "lastUpdateDate": "2026-07-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07597980" }, { "nctId": "NCT07357766", "title": "A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight", "status": "WITHDRAWN", "phases": [ "PHASE3" ], "sponsor": "Novo Nordisk A/S", "sponsorKey": "novo nordisk a/s", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Overweight", "Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-06-22", "primaryCompletionDate": "2027-11-29", "lastUpdateDate": "2026-07-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07357766" }, { "nctId": "NCT04777396", "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Novo Nordisk A/S", "sponsorKey": "novo nordisk a/s", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Early Alzheimer's Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2021-05-18", "primaryCompletionDate": "2025-09-16", "lastUpdateDate": "2026-07-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04777396" }, { "nctId": "NCT07445841", "title": "Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "McGill University", "sponsorKey": "mcgill university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Stroke" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-03-09", "primaryCompletionDate": "2030-01-30", "lastUpdateDate": "2026-07-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07445841" }, { "nctId": "NCT07025226", "title": "Medication Combinations of Dasatinib, Quercetin, Fisetin, Temozolomide, LMP744, and Autologous TLPO Vaccine for the Treatment of Previously Treated Glioma With Residual Disease", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glioma" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-08-12", "primaryCompletionDate": "2027-09-01", "lastUpdateDate": "2026-07-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07025226" }, { "nctId": "NCT04264897", "title": "Antecedent Metabolic Health and Metformin Aging Study", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Oklahoma Medical Research Foundation", "sponsorKey": "oklahoma medical research foundation", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Insulin Sensitivity", "Chronic Disease", "Mitochondria", "Insulin Resistance" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2020-07-29", "primaryCompletionDate": "2025-03-12", "lastUpdateDate": "2026-07-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04264897" }, { "nctId": "NCT07676435", "title": "Ongoing Lung Decline With Age Intensified Response", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Cedars-Sinai Medical Center", "sponsorKey": "cedars-sinai medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Lung Function Decline" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2026-06-17", "primaryCompletionDate": "2027-06-16", "lastUpdateDate": "2026-07-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07676435" }, { "nctId": "NCT07444073", "title": "Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "National University of Singapore", "sponsorKey": "national university of singapore", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Obesity & Overweight" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-06-01", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2026-07-01", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07444073" }, { "nctId": "NCT05593588", "title": "Senolytics Treatment of Interstitial Lung Disease in Common Variable Immunodeficiency", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Avni Joshi", "sponsorKey": "avni joshi", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Common Variable Immunodeficiency", "Interstitial Lung Disease Due to Systemic Disease" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-04-12", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-06-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05593588" }, { "nctId": "NCT04430517", "title": "Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Mclean Hospital", "sponsorKey": "mclean hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment", "Mild Alzheimer Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-03-02", "primaryCompletionDate": "2026-04-29", "lastUpdateDate": "2026-06-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04430517" }, { "nctId": "NCT03629340", "title": "Metformin for Pulmonary Hypertension HFpEF", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "University of California, San Francisco", "sponsorKey": "university of california, san francisco", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pulmonary Hypertension", "Heart Failure" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-02-26", "primaryCompletionDate": "2026-02-27", "lastUpdateDate": "2026-06-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03629340" }, { "nctId": "NCT04026776", "title": "Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Salt; Excess", "Blood Pressure Disorders" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2020-09-02", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-06-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04026776" }, { "nctId": "NCT05720468", "title": "Exercise for Cognitive Excellence in Parkinson's Disease", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of California, San Francisco", "sponsorKey": "university of california, san francisco", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-07-20", "primaryCompletionDate": "2026-05-06", "lastUpdateDate": "2026-06-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05720468" }, { "nctId": "NCT06396416", "title": "Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Western University, Canada", "sponsorKey": "western university, canada", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Chronic Kidney Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-09-26", "primaryCompletionDate": "2026-09-30", "lastUpdateDate": "2026-06-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06396416" }, { "nctId": "NCT07013591", "title": "Nicotinamide Mononucleotide in Patients Undergoing CABG Surgery", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Brigham and Women's Hospital", "sponsorKey": "brigham and women's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Coronary Artery Bypass Graft" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-06-10", "primaryCompletionDate": "2028-10-01", "lastUpdateDate": "2026-06-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07013591" }, { "nctId": "NCT04777409", "title": "A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Novo Nordisk A/S", "sponsorKey": "novo nordisk a/s", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Early Alzheimer´s Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2021-05-18", "primaryCompletionDate": "2025-09-15", "lastUpdateDate": "2026-06-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04777409" }, { "nctId": "NCT06727305", "title": "MTOR Inhibitors in Older Adults", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Senolytics", "Rapamycin" ], "topicKeys": [ "senolytics", "rapamycin" ], "startDate": "2026-05-11", "primaryCompletionDate": "2027-09-01", "lastUpdateDate": "2026-06-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06727305" }, { "nctId": "NCT05237687", "title": "The Role of Sirolimus in Preventing Functional Decline in Older Adults", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Irina Timofte", "sponsorKey": "irina timofte", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2026-03-31", "primaryCompletionDate": "2027-11", "lastUpdateDate": "2026-06-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05237687" }, { "nctId": "NCT07469475", "title": "Effect of a Daily Supplement on Plasma PAI-1 Levels", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of California, Los Angeles", "sponsorKey": "university of california, los angeles", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Endothelial Dysfunction", "Senescence" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-02-24", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-06-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07469475" }, { "nctId": "NCT07004361", "title": "Ethical Issues of Using Gene Therapy in the Treatment of AMD", "status": "RECRUITING", "phases": [], "sponsor": "Nantes University Hospital", "sponsorKey": "nantes university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Exudative Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-07-01", "primaryCompletionDate": "2026-07-01", "lastUpdateDate": "2026-06-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07004361" }, { "nctId": "NCT07572825", "title": "Assessing the Safety and Tolerability of NMN in DHDDS-CDG", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Eva Morava-Kozicz", "sponsorKey": "eva morava-kozicz", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "DHDDS-Congenital Disorder of Glycosylation", "DHDDS-CDG", "Congenital Disorder of Glycosylation" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-05-08", "primaryCompletionDate": "2027-08-01", "lastUpdateDate": "2026-06-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07572825" }, { "nctId": "NCT07603505", "title": "Effect of NAE on Polycystic Ovarian Syndrome (PCOS)", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Jinnah Sindh Medical University", "sponsorKey": "jinnah sindh medical university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Polycystic Ovarian Syndrome (PCOS)", "Infertility", "Metabolic Disorders" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2025-04-10", "primaryCompletionDate": "2026-05-30", "lastUpdateDate": "2026-06-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07603505" }, { "nctId": "NCT07654231", "title": "Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease Mineral and Bone Disorder", "Hypertension", "Diabetes", "Dyslipidemia", "Atherosclerotic Cardiovascular Disease (ASCVD)", "Chronic Kidney Disease (Stage 3)" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-07-01", "primaryCompletionDate": "2027-12-01", "lastUpdateDate": "2026-06-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07654231" }, { "nctId": "NCT02755584", "title": "Study of Skin Cells That Stop Replicating (Senescent) During Wound Healing", "status": "COMPLETED", "phases": [], "sponsor": "National Institute on Aging (NIA)", "sponsorKey": "national institute on aging (nia)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Volunteers" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2016-06-30", "primaryCompletionDate": "2021-04-15", "lastUpdateDate": "2026-06-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02755584" }, { "nctId": "NCT05637216", "title": "Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Shaw Cancer Center", "sponsorKey": "shaw cancer center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Radiation Induced Fibrosis" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-08-17", "primaryCompletionDate": "2027-08-17", "lastUpdateDate": "2026-06-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05637216" }, { "nctId": "NCT05789355", "title": "Effect of NUV001 Supplementation in Patients Suffering From Sickle Cell Disease (SCD)", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "LGD", "sponsorKey": "lgd", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Sickle Cell Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-03-30", "primaryCompletionDate": "2024-05-06", "lastUpdateDate": "2026-06-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05789355" }, { "nctId": "NCT07649161", "title": "Nicotinamide Riboside, Vit B3 Analogue, and Brain Energy Metabolism", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Massachusetts General Hospital", "sponsorKey": "massachusetts general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Adult" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-06", "primaryCompletionDate": "2027-09", "lastUpdateDate": "2026-06-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07649161" }, { "nctId": "NCT06071143", "title": "Safety and Efficacy of KDSTEM Inj. in Patients With Chronic Kidney Disease", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "EHL Bio", "sponsorKey": "ehl bio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Chronic Kidney Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-02-29", "primaryCompletionDate": "2026-03-09", "lastUpdateDate": "2026-06-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06071143" }, { "nctId": "NCT06902740", "title": "PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial Atherosclerosis", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Peking Union Medical College Hospital", "sponsorKey": "peking union medical college hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Intracranial Atherosclerosis", "Intracranial Artery Stenosis", "Atherosclerotic Plaque" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-11-07", "primaryCompletionDate": "2027-12-31", "lastUpdateDate": "2026-06-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06902740" }, { "nctId": "NCT04959175", "title": "Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "National Cancer Institute (NCI)", "sponsorKey": "national cancer institute (nci)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hematologic Neoplasms" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2021-09-23", "primaryCompletionDate": "2027-04-27", "lastUpdateDate": "2026-06-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04959175" }, { "nctId": "NCT05093959", "title": "Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure With Preserved Ejection Fraction" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2022-01-04", "primaryCompletionDate": "2025-12-18", "lastUpdateDate": "2026-06-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05093959" }, { "nctId": "NCT07637487", "title": "Tocotrienol Supplementa as A Senolytic Agent in Middle-aged Adults", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "National University of Malaysia", "sponsorKey": "national university of malaysia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-10-31", "primaryCompletionDate": "2024-12-19", "lastUpdateDate": "2026-06-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07637487" }, { "nctId": "NCT05651620", "title": "The CALERIE™ Legacy Study", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "Tufts University", "sponsorKey": "tufts university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Calorie Restriction" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2023-04-06", "primaryCompletionDate": "2027-01-31", "lastUpdateDate": "2026-06-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05651620" }, { "nctId": "NCT07636369", "title": "The SAVOR Study: Appetite and Physiological Responses", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Singapore Institute of Food and Biotechnology Innovation", "sponsorKey": "singapore institute of food and biotechnology innovation", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anorexia of Aging", "Malnutrition or Risk of Malnutrition" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-06", "primaryCompletionDate": "2026-08", "lastUpdateDate": "2026-06-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07636369" }, { "nctId": "NCT03676478", "title": "Assessing Timing of Enteral Feeding Support in Esophageal Cancer Patients on Muscle functTion and Survival", "status": "TERMINATED", "phases": [ "NA" ], "sponsor": "University Hospital, Gasthuisberg", "sponsorKey": "university hospital, gasthuisberg", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Esophageal Cancer", "Nutrition Aspect of Cancer", "Postoperative Complications", "Muscle Weakness", "Sarcopenia", "Jejunostomy; Complications" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2019-03-25", "primaryCompletionDate": "2025-05-25", "lastUpdateDate": "2026-06-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03676478" }, { "nctId": "NCT04040959", "title": "Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Colorado, Denver", "sponsorKey": "university of colorado, denver", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vascular Diseases", "Kidney Disease", "Blood Pressure", "Oxidative Stress" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-11-19", "primaryCompletionDate": "2026-07-20", "lastUpdateDate": "2026-06-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04040959" }, { "nctId": "NCT07218445", "title": "The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With Obesity", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Menopause Hot Flashes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-04-08", "primaryCompletionDate": "2027-09-18", "lastUpdateDate": "2026-06-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07218445" }, { "nctId": "NCT05356104", "title": "GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Chinese University of Hong Kong", "sponsorKey": "chinese university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cerebral Small Vessel Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-05-25", "primaryCompletionDate": "2027-05", "lastUpdateDate": "2026-06-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05356104" }, { "nctId": "NCT07609160", "title": "Effectiveness of Combined GLP-1/GIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Acibadem University", "sponsorKey": "acibadem university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Sarcopenia", "Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-11-01", "primaryCompletionDate": "2027-11-30", "lastUpdateDate": "2026-06-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07609160" }, { "nctId": "NCT07625202", "title": "Creatine Supplementation During GLP-1a Therapy", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Saskatchewan", "sponsorKey": "university of saskatchewan", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-05-25", "primaryCompletionDate": "2027-05-30", "lastUpdateDate": "2026-06-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07625202" }, { "nctId": "NCT07579429", "title": "Research On Nicotinamide Riboside Supplement Support in MDS (ROSS Trial)", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Colorado, Denver", "sponsorKey": "university of colorado, denver", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Clonal Cytopenia of Undetermined Significance", "Myelodysplastic Syndrome" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-05-20", "primaryCompletionDate": "2029-12-18", "lastUpdateDate": "2026-06-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07579429" }, { "nctId": "NCT07416786", "title": "Validation of NAD+ Measurements for Human Clinical Studies", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "University of Pennsylvania", "sponsorKey": "university of pennsylvania", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Adults" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-07-01", "primaryCompletionDate": "2027-07-31", "lastUpdateDate": "2026-06-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07416786" }, { "nctId": "NCT03565913", "title": "Potential Therapeutic Role of Effervescent Calcium-Magnesium Citrate in Chronic Kidney Disease Stage V", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "CKD Stage 5" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-01-22", "primaryCompletionDate": "2026-12-01", "lastUpdateDate": "2026-06-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03565913" }, { "nctId": "NCT04913805", "title": "Matching Perfusion and Metabolic Activity in HFpEF", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Pennsylvania", "sponsorKey": "university of pennsylvania", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure With Preserved Ejection Fraction" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-10-11", "primaryCompletionDate": "2027-05-01", "lastUpdateDate": "2026-06-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04913805" }, { "nctId": "NCT07620587", "title": "The Role of Estradiol and Progesterone on Appetite Regulation and Energy Balance", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Wilfrid Laurier University", "sponsorKey": "wilfrid laurier university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Energy Balance", "Physiology - Regulation of Appetite and Food Intake" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-06-01", "primaryCompletionDate": "2028-08-31", "lastUpdateDate": "2026-06-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07620587" }, { "nctId": "NCT06658093", "title": "RESTOR: PK/PD mTORi Inhibition in Older Adults", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2026-03-04", "primaryCompletionDate": "2028-07", "lastUpdateDate": "2026-06-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06658093" }, { "nctId": "NCT06864988", "title": "4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "4D Molecular Therapeutics", "sponsorKey": "4d molecular therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "FDMT", "tickerCompany": "4D Molecular Therapeutics Inc", "listingStatus": "ticker", "conditions": [ "Macular Neovascularization Secondary to Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-03-03", "primaryCompletionDate": "2027-06", "lastUpdateDate": "2026-06-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06864988" }, { "nctId": "NCT05949658", "title": "Rapalog Pharmacology (RAP PAC) Study", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "University of Wisconsin, Madison", "sponsorKey": "university of wisconsin, madison", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2024-05-15", "primaryCompletionDate": "2027-03", "lastUpdateDate": "2026-05-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05949658" }, { "nctId": "NCT06485089", "title": "Effects of Tirzepatide on Blood, Imaging and Breast Tissue Biomarkers", "status": "COMPLETED", "phases": [], "sponsor": "University of Kansas Medical Center", "sponsorKey": "university of kansas medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Breast Cancer Risk" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-09-14", "primaryCompletionDate": "2026-03-25", "lastUpdateDate": "2026-05-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06485089" }, { "nctId": "NCT06620666", "title": "NEUROmuscular Training for Enhanced AGE Longevity", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "University of Valencia", "sponsorKey": "university of valencia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Physical Activity", "Training" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-01-24", "primaryCompletionDate": "2027-07-15", "lastUpdateDate": "2026-05-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06620666" }, { "nctId": "NCT05706389", "title": "Does Alpha-ketoglutarate Supplementation Lower BiologicaL agE in Middle- Aged Adults?", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "National University of Singapore", "sponsorKey": "national university of singapore", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2023-02-24", "primaryCompletionDate": "2025-08-15", "lastUpdateDate": "2026-05-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05706389" }, { "nctId": "NCT04460170", "title": "COVID-19 Follow up Intensive Care Studies", "status": "COMPLETED", "phases": [], "sponsor": "University Medical Center Groningen", "sponsorKey": "university medical center groningen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Quality of Life", "COVID-19" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2020-07-01", "primaryCompletionDate": "2022-02-01", "lastUpdateDate": "2026-05-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04460170" }, { "nctId": "NCT06044935", "title": "Effect of Nicotinamide Riboside on Ketosis, Fat Oxidation & Metabolic Rate", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "sponsorKey": "national institute of diabetes and digestive and kidney diseases (niddk)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight", "Obesity" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-01-08", "primaryCompletionDate": "2027-01-31", "lastUpdateDate": "2026-05-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06044935" }, { "nctId": "NCT06856577", "title": "Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-Related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)", "Wet AMD" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-02-28", "primaryCompletionDate": "2026-12-22", "lastUpdateDate": "2026-05-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06856577" }, { "nctId": "NCT06373731", "title": "ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Stealth BioTherapeutics", "sponsorKey": "stealth biotherapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age Related Macular Degeneration (ARMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2024-05-30", "primaryCompletionDate": "2027-08", "lastUpdateDate": "2026-05-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06373731" }, { "nctId": "NCT02848131", "title": "Senescence in Chronic Kidney Disease", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2016-07", "primaryCompletionDate": "2027-04", "lastUpdateDate": "2026-05-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02848131" }, { "nctId": "NCT06431932", "title": "Pilot Trial of Fisetin in Healthy Volunteers and Older Patients With Multimorbidity", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Ove Andersen", "sponsorKey": "ove andersen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multimorbidity", "Healthy" ], "topics": [ "Senolytics", "Klotho" ], "topicKeys": [ "senolytics", "klotho" ], "startDate": "2026-03-24", "primaryCompletionDate": "2028-12-31", "lastUpdateDate": "2026-05-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06431932" }, { "nctId": "NCT07195318", "title": "Fisetin Supplementation for Healthy Aging", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Ove Andersen", "sponsorKey": "ove andersen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-09-24", "primaryCompletionDate": "2026-10-31", "lastUpdateDate": "2026-05-19", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07195318" }, { "nctId": "NCT04614714", "title": "Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "University of California, Davis", "sponsorKey": "university of california, davis", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Preterm Birth", "Inadequate Milk Production" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-06-01", "primaryCompletionDate": "2026-06-30", "lastUpdateDate": "2026-05-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04614714" }, { "nctId": "NCT07588984", "title": "GLP-1 Medication & Behavioral Health Programs on Weight & Metabolic Outcomes: FLOURISH and THRIVE Prospective Cohort Study", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Noom", "sponsorKey": "noom", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Obesity & Overweight", "Weight Loss", "Preventative Health", "Body Weight", "Cardiovascular Disease Risk Factor" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-04-30", "primaryCompletionDate": "2029-05", "lastUpdateDate": "2026-05-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07588984" }, { "nctId": "NCT05924295", "title": "Variations in Ketone Metabolism", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Ohio State University", "sponsorKey": "ohio state university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ketosis" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2023-06-20", "primaryCompletionDate": "2026-11-01", "lastUpdateDate": "2026-05-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05924295" }, { "nctId": "NCT06348771", "title": "Postprandial Inflammation and Nuts (PIN) in Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Rutgers, The State University of New Jersey", "sponsorKey": "rutgers, the state university of new jersey", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Aging", "Overweight and Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-03-25", "primaryCompletionDate": "2025-01-06", "lastUpdateDate": "2026-05-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06348771" }, { "nctId": "NCT07567378", "title": "CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "JULIO GRANADOS MONTIEL", "sponsorKey": "julio granados montiel", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Psoriatic Arthritis", "Osteoarthitis", "Knee", "Diabetes (DM)", "Type 2 Diabetes Mellitus (T2DM)", "Obesity (Disorder)", "Insulin Resistance Syndrome", "Metabolic Syndrome", "Heart Failure", "Preserved Ejection Fraction", "Coronary Artery Disease", "Atrial Fibrillation (AF)", "Non Alcholic Fatty Liver Disease", "Sarcopenia", "Pericardium" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-05", "primaryCompletionDate": "2027-11", "lastUpdateDate": "2026-05-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07567378" }, { "nctId": "NCT06018467", "title": "Senolytics to Improve Osteoporosis Therapy", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Odense University Hospital", "sponsorKey": "odense university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteopenia, Osteoporosis", "Age-related Bone Loss" ], "topics": [ "Senolytics", "NAD+/NMN" ], "topicKeys": [ "senolytics", "nad_nmn" ], "startDate": "2023-09-06", "primaryCompletionDate": "2026-04-30", "lastUpdateDate": "2026-05-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06018467" }, { "nctId": "NCT06592859", "title": "Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "People's Hospital of Quzhou", "sponsorKey": "people's hospital of quzhou", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "NMN" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-08-23", "primaryCompletionDate": "2026-05-24", "lastUpdateDate": "2026-05-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06592859" }, { "nctId": "NCT07083557", "title": "Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)", "status": "RECRUITING", "phases": [], "sponsor": "Bettina Mittendorfer", "sponsorKey": "bettina mittendorfer", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity and Obesity-related Medical Conditions", "Diabetes", "Atherosclerotic Disease", "Heart Failure", "MASH", "Sarcopenia", "Osteoporosis", "Hyperparathyroidism", "Hypoparathyroidism", "Ischemic Heart Disease", "Cystic Fibrosis (CF)", "Chronic Kidney Disease(CKD)", "Osteopenia", "Cachexia" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2027-01-01", "primaryCompletionDate": "2030-07-01", "lastUpdateDate": "2026-05-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07083557" }, { "nctId": "NCT07571928", "title": "A Novel Aromatase Inhibitor, Leflutrozole, for Treatment of Non-Obstructive Azoospermia", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Martin Blomberg Jensen", "sponsorKey": "martin blomberg jensen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility Due to Azoospermia", "Infertility, Male" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-05-01", "primaryCompletionDate": "2027-05-31", "lastUpdateDate": "2026-05-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07571928" }, { "nctId": "NCT07563322", "title": "Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Vanderbilt University Medical Center", "sponsorKey": "vanderbilt university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pulmonary Hypertension" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-04-09", "primaryCompletionDate": "2027-04-30", "lastUpdateDate": "2026-05-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07563322" }, { "nctId": "NCT06073717", "title": "Motor-cognitive Training Effects on Cognition in Breast Cancer Survivors: the BRAINonFIT Study (BRAINonFIT).", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "University of Seville", "sponsorKey": "university of seville", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Breast Cancer Survivors", "Cognitive Impairment", "Executive Dysfunction" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-10-01", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2026-05-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06073717" }, { "nctId": "NCT07504068", "title": "Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall Health in Adults With a Metabolically Challenging Profile", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Valencia", "sponsorKey": "university of valencia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Adults With Overweight and Obesity", "Supplementation", "Exercise" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-03-25", "primaryCompletionDate": "2026-07-30", "lastUpdateDate": "2026-05-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07504068" }, { "nctId": "NCT04742751", "title": "An Open-Label Pilot Intervention Trial to Prevent Diabetes in Prediabetic Adult Survivors of Childhood Cancer", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "St. Jude Children's Research Hospital", "sponsorKey": "st. jude children's research hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "PreDiabetes", "Adult Children" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2022-03-02", "primaryCompletionDate": "2026-01-16", "lastUpdateDate": "2026-04-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04742751" }, { "nctId": "NCT07275359", "title": "Investigating Senolytic Properties in Pulmonary Rehabilitation and Metformin in COPD Exacerbations", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Duke University", "sponsorKey": "duke university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Obstructive Pulmonary Disease (COPD)" ], "topics": [ "Senolytics", "Metformin / TAME" ], "topicKeys": [ "senolytics", "metformin" ], "startDate": "2026-09-01", "primaryCompletionDate": "2028-09-01", "lastUpdateDate": "2026-04-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07275359" }, { "nctId": "NCT06971822", "title": "Assessing the Impact of a Leucine Enriched Whey Protein vs Isonitrogenous Whey on Muscle Protein Synthetic Responses in the Rested and Acute Post Exercise States in Older Adults", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Nottingham", "sponsorKey": "university of nottingham", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Male Volunteers Over 65" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2025-03-14", "primaryCompletionDate": "2029-02-01", "lastUpdateDate": "2026-04-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06971822" }, { "nctId": "NCT04704921", "title": "Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "AMD", "nAMD", "Wet Age-related Macular Degeneration", "wAMD", "Wet AMD", "CNV", "Neovascular AMD", "Neovascular Age-related Macular Degeneration", "Choroidal Neovascularization" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2020-12-29", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-04-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04704921" }, { "nctId": "NCT07554417", "title": "Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "William Marsh Rice University", "sponsorKey": "william marsh rice university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "GLP - 1", "Obesity & Overweight", "Muscle Loss", "Exercise Intervention", "Dietary Assessment" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-04-06", "primaryCompletionDate": "2026-06-29", "lastUpdateDate": "2026-04-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07554417" }, { "nctId": "NCT06789653", "title": "A Novel Approach Utilizing Organ Specific Age Proteomics", "status": "RECRUITING", "phases": [], "sponsor": "UNC Lineberger Comprehensive Cancer Center", "sponsorKey": "unc lineberger comprehensive cancer center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Breast Cancer" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-10-10", "primaryCompletionDate": "2026-08-01", "lastUpdateDate": "2026-04-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06789653" }, { "nctId": "NCT04733534", "title": "An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "St. Jude Children's Research Hospital", "sponsorKey": "st. jude children's research hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty", "Childhood Cancer" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-06-06", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-04-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04733534" }, { "nctId": "NCT05205317", "title": "Comparison of the Therapeutic Effects of VR and VR + Metformin in the Treatment of Cesarean Section Scar Defect", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Xinhua Hospital, Shanghai Jiao Tong University School of Medicine", "sponsorKey": "xinhua hospital, shanghai jiao tong university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Defect" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2023-04-15", "primaryCompletionDate": "2027-01-30", "lastUpdateDate": "2026-04-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05205317" }, { "nctId": "NCT07544420", "title": "aKLmRNA-mediated Protein Replacement Therapy", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Klothea Bio", "sponsorKey": "klothea bio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Aging" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-05-15", "primaryCompletionDate": "2026-11-30", "lastUpdateDate": "2026-04-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07544420" }, { "nctId": "NCT05838560", "title": "Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Washington University School of Medicine", "sponsorKey": "washington university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Schizophrenia", "Treatment Resistant Depression", "Aging, Premature" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-07-01", "primaryCompletionDate": "2027-10-01", "lastUpdateDate": "2026-04-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05838560" }, { "nctId": "NCT05746039", "title": "Feasibility of Semaglutide in Advanced Lung Disease", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Pennsylvania", "sponsorKey": "university of pennsylvania", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Interstitial Lung Disease", "Chronic Obstructive Pulmonary Disease", "Sarcoidosis, Pulmonary", "Pulmonary Hypertension" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-01-29", "primaryCompletionDate": "2027-12-28", "lastUpdateDate": "2026-04-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05746039" }, { "nctId": "NCT04741646", "title": "Ferric Citrate and Chronic Kidney Disease in Children", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of California, Los Angeles", "sponsorKey": "university of california, los angeles", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-06-17", "primaryCompletionDate": "2027-10", "lastUpdateDate": "2026-04-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04741646" }, { "nctId": "NCT06745544", "title": "Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Aalborg University Hospital", "sponsorKey": "aalborg university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes", "Osteoporosis", "Diabetic Neuropathies", "Fall Prevention", "Cardiovascular Diseases" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-01", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2026-04-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06745544" }, { "nctId": "NCT07064759", "title": "Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration", "status": "RECRUITING", "phases": [ "PHASE3" ], "sponsor": "4D Molecular Therapeutics", "sponsorKey": "4d molecular therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "FDMT", "tickerCompany": "4D Molecular Therapeutics Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-07-22", "primaryCompletionDate": "2028-11", "lastUpdateDate": "2026-04-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07064759" }, { "nctId": "NCT06399809", "title": "Fisetin to Reduce Senescence and Mobility Impairment in PAD", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Northwestern University", "sponsorKey": "northwestern university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Peripheral Arterial Disease", "Aging", "Peripheral Vascular Diseases", "Walking, Difficulty", "Claudication" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-09-30", "primaryCompletionDate": "2026-11", "lastUpdateDate": "2026-04-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06399809" }, { "nctId": "NCT05506488", "title": "Dasatinib and Quercetin to Treat Fibrotic Non-alcoholic Fatty Liver Disease", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "sponsorKey": "academisch medisch centrum - universiteit van amsterdam (amc-uva)", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "NAFLD", "NASH With Fibrosis", "Liver Fibrosis" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-07-05", "primaryCompletionDate": "2026-02-26", "lastUpdateDate": "2026-04-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05506488" }, { "nctId": "NCT05068830", "title": "Safety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's Disease", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Norwegian University of Science and Technology", "sponsorKey": "norwegian university of science and technology", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2021-09-17", "primaryCompletionDate": "2027-03-01", "lastUpdateDate": "2026-04-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05068830" }, { "nctId": "NCT06811324", "title": "Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity Prevention", "Sarcopenia in Elderly", "Cardiovascular Function", "GLP - 1", "Weight Loss" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-04-01", "primaryCompletionDate": "2027-04-01", "lastUpdateDate": "2026-04-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06811324" }, { "nctId": "NCT07529561", "title": "Efficacy of CL25216 on Hormonal Balance and Menstrual Health in Women With Primary Dysmenorrhea.", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "ApexCPG", "sponsorKey": "apexcpg", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Primary Dysmenorrhea", "Menstural Cramps" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-04-13", "primaryCompletionDate": "2026-09-10", "lastUpdateDate": "2026-04-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07529561" }, { "nctId": "NCT05759468", "title": "NAD Augmentation in Diabetes Kidney Disease", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Brigham and Women's Hospital", "sponsorKey": "brigham and women's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type2diabetes", "Diabetic Kidney Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-04-13", "primaryCompletionDate": "2026-11-30", "lastUpdateDate": "2026-04-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05759468" }, { "nctId": "NCT07521189", "title": "Effect of Vegetarien Diet on Protein Digestibility in Young and Elderly Volunteers", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement", "sponsorKey": "institut national de recherche pour l'agriculture, l'alimentation et l'environnement", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vegetarian Diet", "Elderly", "Young Healthy Adults" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-22", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2026-04-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07521189" }, { "nctId": "NCT06817343", "title": "A Long-term Follow up Study of EXG102-031 in Patients With wAMD (Everest LTFU)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Exegenesis Bio", "sponsorKey": "exegenesis bio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)", "Neovascular (Wet) Age-related Macular Degeneration (AMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2024-09-10", "primaryCompletionDate": "2029-02", "lastUpdateDate": "2026-04-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06817343" }, { "nctId": "NCT05903794", "title": "A Study of EXG102-031 in Patients With wAMD (Everest)", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Exegenesis Bio", "sponsorKey": "exegenesis bio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular (Wet) Age-related Macular Degeneration (nAMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-07-24", "primaryCompletionDate": "2026-02-16", "lastUpdateDate": "2026-04-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05903794" }, { "nctId": "NCT06789900", "title": "Everolimus and/or Exercise to Prevent Bone Loss in Postmenopausal Women", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Odense University Hospital", "sponsorKey": "odense university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Postmenopausal Women" ], "topics": [ "Senolytics", "Rapamycin" ], "topicKeys": [ "senolytics", "rapamycin" ], "startDate": "2024-10-14", "primaryCompletionDate": "2026-03-01", "lastUpdateDate": "2026-04-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06789900" }, { "nctId": "NCT07191353", "title": "Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Odense University Hospital", "sponsorKey": "odense university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy", "Osteopenia", "Osteoporosis Risk" ], "topics": [ "Senolytics", "Rapamycin" ], "topicKeys": [ "senolytics", "rapamycin" ], "startDate": "2025-10-20", "primaryCompletionDate": "2027-03-01", "lastUpdateDate": "2026-04-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07191353" }, { "nctId": "NCT06534944", "title": "NAD Supplementation and Vascular Health in PAD", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Oklahoma", "sponsorKey": "university of oklahoma", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Peripheral Artery Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-02-27", "primaryCompletionDate": "2024-07-30", "lastUpdateDate": "2026-04-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06534944" }, { "nctId": "NCT06214468", "title": "Protective Effect of Nicotinamide Riboside Against Acetaminophen Toxicity", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "University of South Alabama", "sponsorKey": "university of south alabama", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Drug Toxicity" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-01-15", "primaryCompletionDate": "2025-04-01", "lastUpdateDate": "2026-04-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06214468" }, { "nctId": "NCT07506681", "title": "IMAT Quality in Aging", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Washington University School of Medicine", "sponsorKey": "washington university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2026-04-15", "primaryCompletionDate": "2028-01", "lastUpdateDate": "2026-04-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07506681" }, { "nctId": "NCT07495904", "title": "Effect of GLP-1 Receptor Agonists on Body Composition in Obesity: The Role of Dietary Protein Consumption in Muscle Mass Maintenance", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Hellenic Mediterranean University", "sponsorKey": "hellenic mediterranean university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-03-30", "primaryCompletionDate": "2028-03-30", "lastUpdateDate": "2026-04-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07495904" }, { "nctId": "NCT04685590", "title": "Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Washington University School of Medicine", "sponsorKey": "washington university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease, Early Onset", "Mild Cognitive Impairment" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-12-22", "primaryCompletionDate": "2028-01", "lastUpdateDate": "2026-04-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04685590" }, { "nctId": "NCT05483465", "title": "The Effect of NAD Supplementation on Brain Vascular Health in Aging", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "University of Oklahoma", "sponsorKey": "university of oklahoma", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-05-03", "primaryCompletionDate": "2027-06", "lastUpdateDate": "2026-04-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05483465" }, { "nctId": "NCT07501377", "title": "Effects of a 6-months Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Perimenopausal Women Living With Overweight or Obesity", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Max Planck Institute for Human Cognitive and Brain Sciences", "sponsorKey": "max planck institute for human cognitive and brain sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight and/or Obesity", "Perimenopausal Women" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-03-19", "primaryCompletionDate": "2029-06-30", "lastUpdateDate": "2026-03-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07501377" }, { "nctId": "NCT07361874", "title": "IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Autonomous Cortisol Secretion (MACS)", "Autonomous Cortisol Secretion (ACS)", "Subclinical Cushing's", "Mild Autonomous Cortisol Excess" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-03-05", "primaryCompletionDate": "2030-05-31", "lastUpdateDate": "2026-03-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07361874" }, { "nctId": "NCT07476859", "title": "Effect of Intravenous Iron on Quality of Life in Older Patients With Acute Coronary Syndrome", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Fundación para la Investigación del Hospital Clínico de Valencia", "sponsorKey": "fundación para la investigación del hospital clínico de valencia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Acute Coronary Syndromes (ACS)", "Iron Deficiencies", "Elderly (People Aged 65 or More)" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-03-05", "primaryCompletionDate": "2028-04", "lastUpdateDate": "2026-03-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07476859" }, { "nctId": "NCT07220473", "title": "Tirzepatide to Slow Biological Aging", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Medical Branch, Galveston", "sponsorKey": "the university of texas medical branch, galveston", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "LONGEVITY 1" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-02-27", "primaryCompletionDate": "2027-11", "lastUpdateDate": "2026-03-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07220473" }, { "nctId": "NCT06587945", "title": "Nicotinamide Riboside Oral Supplementation in Macula Off Retinal Detachment", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Center for Eye Research Australia", "sponsorKey": "center for eye research australia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Retinal Detachment" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-09-19", "primaryCompletionDate": "2027-10-30", "lastUpdateDate": "2026-03-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06587945" }, { "nctId": "NCT07485062", "title": "Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Western University, Canada", "sponsorKey": "western university, canada", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes", "Cognitive Decline in Older Adults" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2026-05-01", "primaryCompletionDate": "2029-05-01", "lastUpdateDate": "2026-03-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07485062" }, { "nctId": "NCT02553954", "title": "Molecular Mechanisms of Senescence Predisposing to Cancer : Exploratory Analysis on Healthy Tissues (SkinAge).", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Centre Oscar Lambret", "sponsorKey": "centre oscar lambret", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcoma" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2014-10-07", "primaryCompletionDate": "2019-04-16", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02553954" }, { "nctId": "NCT05653258", "title": "Single Nuclei RNA-seq to Map Adipose Cellular Populations and Senescent Cells in Older Subjects", "status": "RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Cedars-Sinai Medical Center", "sponsorKey": "cedars-sinai medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Healthy Lifestyle" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-10-17", "primaryCompletionDate": "2027-02-01", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05653258" }, { "nctId": "NCT07344636", "title": "Effects of NR Supplementation on Metabolic Flexibility in Zone 2 Training", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "ZHANG Jiaqi", "sponsorKey": "zhang jiaqi", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Health Adult Subjects" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-01-06", "primaryCompletionDate": "2027-07", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07344636" }, { "nctId": "NCT07475208", "title": "NR and Exercise for Blood Pressure", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "ZHANG Jiaqi", "sponsorKey": "zhang jiaqi", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension (HTN)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-04", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07475208" }, { "nctId": "NCT06345443", "title": "NRM on Vascular Perfusion in Healthy Adults", "status": "ENROLLING_BY_INVITATION", "phases": [ "NA" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vascular Stiffness" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-11-25", "primaryCompletionDate": "2026-09-30", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06345443" }, { "nctId": "NCT06910475", "title": "Physical Exercise and Biomolecular Analysis to Reduce Uremic Toxins in Chronic Kidney Disease: An Exploratory Study", "status": "ENROLLING_BY_INVITATION", "phases": [ "NA" ], "sponsor": "Catholic University of Brasília", "sponsorKey": "catholic university of brasília", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Disease, Chronic", "Kidney Failure Chronic" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-04-01", "primaryCompletionDate": "2026-03-15", "lastUpdateDate": "2026-03-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06910475" }, { "nctId": "NCT07475546", "title": "Combination Gerotherapeutic Interventions for Healthspan Improvement", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "AgelessRx", "sponsorKey": "agelessrx", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthspan Improvement", "Aging", "Longevity" ], "topics": [ "Rapamycin", "Metformin / TAME" ], "topicKeys": [ "rapamycin", "metformin" ], "startDate": "2025-07-23", "primaryCompletionDate": "2026-04", "lastUpdateDate": "2026-03-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07475546" }, { "nctId": "NCT05781711", "title": "Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Tanta University", "sponsorKey": "tanta university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2023-01-06", "primaryCompletionDate": "2025-01-20", "lastUpdateDate": "2026-03-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05781711" }, { "nctId": "NCT04192136", "title": "NAD+ and Exercise in FA", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Children's Hospital of Philadelphia", "sponsorKey": "children's hospital of philadelphia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Friedreich Ataxia 1" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-09-03", "primaryCompletionDate": "2025-02-07", "lastUpdateDate": "2026-03-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04192136" }, { "nctId": "NCT04571008", "title": "Effect of NMN Supplementation on Organ System Biology", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Washington University School of Medicine", "sponsorKey": "washington university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glucose Metabolism Disorders" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-10-01", "primaryCompletionDate": "2025-03-04", "lastUpdateDate": "2026-03-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04571008" }, { "nctId": "NCT07053358", "title": "Safety and Efficacy Evaluation of LX111 Gene Therapy in nAMD Patients", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine", "sponsorKey": "shanghai general hospital, shanghai jiao tong university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-07-02", "primaryCompletionDate": "2026-11-23", "lastUpdateDate": "2026-03-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07053358" }, { "nctId": "NCT07460609", "title": "Exploring Blood Flow Restriction as an Accessible Fitness Solution for Healthy Aging in Seniors", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "Baylor University", "sponsorKey": "baylor university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Ageing" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-08-01", "primaryCompletionDate": "2026-03-15", "lastUpdateDate": "2026-03-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07460609" }, { "nctId": "NCT06196840", "title": "Safety and Efficacy of LX102 Gene Therapy in Patients With Neovascular Age-related Macular Degeneration (nAMD) (VENUS)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Innostellar Biotherapeutics", "sponsorKey": "innostellar biotherapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2024-01-24", "primaryCompletionDate": "2025-06-24", "lastUpdateDate": "2026-03-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06196840" }, { "nctId": "NCT05732909", "title": "The Metabolic Effects of β-hydroxybutyrate on Working Skeletal Muscle", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Aarhus", "sponsorKey": "university of aarhus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Metabolism Disorder", "Ketonemia", "Muscle Disorder" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-12-22", "primaryCompletionDate": "2024-01-10", "lastUpdateDate": "2026-03-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05732909" }, { "nctId": "NCT07454252", "title": "Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism", "status": "RECRUITING", "phases": [], "sponsor": "IRCCS San Raffaele", "sponsorKey": "irccs san raffaele", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Bone Remodeling", "Energy Metabolism" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-10", "primaryCompletionDate": "2025-11-01", "lastUpdateDate": "2026-03-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07454252" }, { "nctId": "NCT07451496", "title": "PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "National University of Singapore", "sponsorKey": "national university of singapore", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ageing" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-09-29", "primaryCompletionDate": "2026-02-23", "lastUpdateDate": "2026-03-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07451496" }, { "nctId": "NCT07453290", "title": "Dysregulation of the Soluble α-Klotho-FGF23 Axis in Hashimoto's Thyroiditis: A Case-Control Study", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital", "sponsorKey": "sehit prof. dr. ilhan varank sancaktepe training and research hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Autoimmune Thyroiditis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-03-02", "primaryCompletionDate": "2026-05-20", "lastUpdateDate": "2026-03-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07453290" }, { "nctId": "NCT07254429", "title": "COMPASS - COpenhagen MenoPAuSe Study", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Martin Blomberg Jensen", "sponsorKey": "martin blomberg jensen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Menopausal Osteoporosis", "Bone Markers" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-10-02", "primaryCompletionDate": "2027-12", "lastUpdateDate": "2026-03-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07254429" }, { "nctId": "NCT04514653", "title": "RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-Related Macular Degeneration (nAMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2020-08-25", "primaryCompletionDate": "2026-08", "lastUpdateDate": "2026-02-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04514653" }, { "nctId": "NCT07429955", "title": "Impact of Pre-operative Sarcopenia on Functional Recovery After Hip Arthroplasty in Older Adults", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "University Hospital, Montpellier", "sponsorKey": "university hospital, montpellier", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia in Elderly", "Osteoarthritis (OA)", "Hip Fracture Surgeries" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2026-02", "primaryCompletionDate": "2027-08", "lastUpdateDate": "2026-02-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07429955" }, { "nctId": "NCT05789108", "title": "Deep Venous Thrombosis and Long Term Complications", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Ove Andersen", "sponsorKey": "ove andersen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "DVT of Legs" ], "topics": [ "Senolytics", "Klotho" ], "topicKeys": [ "senolytics", "klotho" ], "startDate": "2023-03-14", "primaryCompletionDate": "2029-09-01", "lastUpdateDate": "2026-02-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05789108" }, { "nctId": "NCT07144527", "title": "Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Scott Silveira", "sponsorKey": "scott silveira", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Frailty", "Exercise Tolerance", "Healthy Male and Female Subjects" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-02-21", "primaryCompletionDate": "2026-12-30", "lastUpdateDate": "2026-02-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07144527" }, { "nctId": "NCT06627868", "title": "Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Turku", "sponsorKey": "university of turku", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity, Abdominal" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-11-20", "primaryCompletionDate": "2027-08-31", "lastUpdateDate": "2026-02-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06627868" }, { "nctId": "NCT02070835", "title": "Cellular Reprogramming-Enhanced Skin Grafting for Diabetic Foot Ulcers", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Hu Zhicheng", "sponsorKey": "hu zhicheng", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetic Foot Ulcer" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2017-08-01", "primaryCompletionDate": "2023-12-30", "lastUpdateDate": "2026-02-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02070835" }, { "nctId": "NCT07414212", "title": "Evaluation of the Combined Therapy of EH-301 and N-acetylcysteine Together With Riluzole in Amyotrophic Lateral Sclerosis (ALS)", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Biogipuzkoa Health Research Institute", "sponsorKey": "biogipuzkoa health research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-11-25", "primaryCompletionDate": "2026-11-25", "lastUpdateDate": "2026-02-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07414212" }, { "nctId": "NCT07216781", "title": "Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Minicircle", "sponsorKey": "minicircle", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Adults" ], "topics": [ "Gene therapy (longevity)", "Klotho" ], "topicKeys": [ "gene_therapy", "klotho" ], "startDate": "2025-10-06", "primaryCompletionDate": "2026-08", "lastUpdateDate": "2026-02-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07216781" }, { "nctId": "NCT05197270", "title": "4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "4D Molecular Therapeutics", "sponsorKey": "4d molecular therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "FDMT", "tickerCompany": "4D Molecular Therapeutics Inc", "listingStatus": "ticker", "conditions": [ "Neovascular (Wet) Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2021-12-09", "primaryCompletionDate": "2027-03", "lastUpdateDate": "2026-02-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05197270" }, { "nctId": "NCT04645212", "title": "Long-term Study of ADVM-022 in Neovascular (Wet) AMD [OPTIC-EXT]", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Wet Age-related Macular Degeneration", "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2020-12-14", "primaryCompletionDate": "2030-06-26", "lastUpdateDate": "2026-02-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04645212" }, { "nctId": "NCT06203392", "title": "Effects of a Very Low Carbohydrate Ketogenic Diet or Mediterranean Diet on Markers of Musculoskeletal Health in Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Florida", "sponsorKey": "university of florida", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Musculoskeletal Diseases" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-07-15", "primaryCompletionDate": "2025-11-24", "lastUpdateDate": "2026-01-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06203392" }, { "nctId": "NCT05590468", "title": "A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Ralitza Gavrilova", "sponsorKey": "ralitza gavrilova", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mitochondrial Myopathy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-05-26", "primaryCompletionDate": "2026-11", "lastUpdateDate": "2026-01-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05590468" }, { "nctId": "NCT05878119", "title": "Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training Program", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Metro International Biotech", "sponsorKey": "metro international biotech", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-10-25", "primaryCompletionDate": "2025-06-17", "lastUpdateDate": "2026-01-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05878119" }, { "nctId": "NCT07354620", "title": "A Pilot Study on Reverse Aging (The REVERSE Study)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "The Christ Hospital", "sponsorKey": "the christ hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2025-02-15", "primaryCompletionDate": "2026-02", "lastUpdateDate": "2026-01-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07354620" }, { "nctId": "NCT05984927", "title": "NG101 AAV Gene Therapy in Subjects With Wet Age-Related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Elisigen", "sponsorKey": "elisigen", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-09-08", "primaryCompletionDate": "2026-01", "lastUpdateDate": "2026-01-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05984927" }, { "nctId": "NCT06044025", "title": "A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "University of Arkansas", "sponsorKey": "university of arkansas", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Castration Sensitive Prostate Cancer" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2024-04-11", "primaryCompletionDate": "2027-10", "lastUpdateDate": "2026-01-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06044025" }, { "nctId": "NCT01678872", "title": "A Follow-up Study to Evaluate the Safety of RetinoStat® in Patients With Age-Related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Oxford BioMedica", "sponsorKey": "oxford biomedica", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "OXB.L", "tickerCompany": "Oxford Biomedica plc", "listingStatus": "ticker", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2012-08", "primaryCompletionDate": "2029-03", "lastUpdateDate": "2026-01-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01678872" }, { "nctId": "NCT04562831", "title": "The NO-ALS Study: A Trial of Nicotinamide/Pterostilbene Supplement in ALS.", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-10-07", "primaryCompletionDate": "2026-10-31", "lastUpdateDate": "2026-01-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04562831" }, { "nctId": "NCT07328100", "title": "Efficacy and Safety of Coenzyme I for Injection on Vascular Aging.", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Shanghai 10th People's Hospital", "sponsorKey": "shanghai 10th people's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vascular Aging", "NAD" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2026-01-16", "primaryCompletionDate": "2027-06-30", "lastUpdateDate": "2026-01-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07328100" }, { "nctId": "NCT06825858", "title": "A Phase I, Open-label, Multicenter, Dose-Escalating Study to Evaluate the Safety and Tolerability of KH658 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Chengdu Origen Biotechnology", "sponsorKey": "chengdu origen biotechnology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-04-07", "primaryCompletionDate": "2027-01", "lastUpdateDate": "2026-01-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06825858" }, { "nctId": "NCT07285629", "title": "Safety and Efficacy of Klotho and Follistatin Gene Therapy", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Minicircle", "sponsorKey": "minicircle", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Adults" ], "topics": [ "Gene therapy (longevity)", "Klotho" ], "topicKeys": [ "gene_therapy", "klotho" ], "startDate": "2025-12-16", "primaryCompletionDate": "2026-06", "lastUpdateDate": "2026-01-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07285629" }, { "nctId": "NCT03685253", "title": "Nicotinamide Riboside for Diabetic Neuropathy", "status": "TERMINATED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Maryland, Baltimore", "sponsorKey": "university of maryland, baltimore", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetic Neuropathy Peripheral" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-01-24", "primaryCompletionDate": "2022-05-01", "lastUpdateDate": "2026-01-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03685253" }, { "nctId": "NCT04221750", "title": "Diet and Exercise Plus Metformin to Treat Frailty in Obese Seniors", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "VA Office of Research and Development", "sponsorKey": "va office of research and development", "sponsorType": "government", "sponsorClass": "FED", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty", "Sarcopenic Obesity", "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2021-05-14", "primaryCompletionDate": "2025-07-31", "lastUpdateDate": "2026-01-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04221750" }, { "nctId": "NCT05657301", "title": "Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Chengdu Origen Biotechnology", "sponsorKey": "chengdu origen biotechnology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-10-16", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2025-12-31", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05657301" }, { "nctId": "NCT07203196", "title": "Circadian Health Regulation and Optimization for Rejuvenation Outcomes", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "Salk Institute for Biological Studies", "sponsorKey": "salk institute for biological studies", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging, Healthy", "Blood Sugar; High", "Blood Sugar (Glucose) Control", "Time Restricted Eating", "Circadian Dysregulation" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-22", "primaryCompletionDate": "2026-04-01", "lastUpdateDate": "2025-12-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07203196" }, { "nctId": "NCT07226947", "title": "Body Composition and Exercise to Prevent Muscle Loss With GLP1 Agonist Treatment", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Massachusetts General Hospital", "sponsorKey": "massachusetts general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Body Composition" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-11-24", "primaryCompletionDate": "2027-06", "lastUpdateDate": "2025-12-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07226947" }, { "nctId": "NCT05836025", "title": "Effect of Rapamycin in Ovarian Aging", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Columbia University", "sponsorKey": "columbia university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Perimenopausal" ], "topics": [ "Rapamycin", "Klotho" ], "topicKeys": [ "rapamycin", "klotho" ], "startDate": "2023-06-01", "primaryCompletionDate": "2025-10-21", "lastUpdateDate": "2025-12-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05836025" }, { "nctId": "NCT07302932", "title": "Metformin and Molecular Aging in Prediabetes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Diabetes Foundation, India", "sponsorKey": "diabetes foundation, india", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Metformin, Prediabetes" ], "topics": [ "Rapamycin", "Metformin / TAME" ], "topicKeys": [ "rapamycin", "metformin" ], "startDate": "2023-02-01", "primaryCompletionDate": "2025-01-30", "lastUpdateDate": "2025-12-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07302932" }, { "nctId": "NCT07293325", "title": "Semaglutide and Tirzepatide for Genetic Aging Delay in Adults With Obesity", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Second Affiliated Hospital, Zhejiang University, School of Medicine", "sponsorKey": "second affiliated hospital, zhejiang university, school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Adults With Simple Obesity" ], "topics": [ "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "metformin", "glp1_aging" ], "startDate": "2025-06-02", "primaryCompletionDate": "2027-04-02", "lastUpdateDate": "2025-12-19", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07293325" }, { "nctId": "NCT05145309", "title": "Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2026-11-15", "primaryCompletionDate": "2031-12-01", "lastUpdateDate": "2025-12-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05145309" }, { "nctId": "NCT07284225", "title": "Acute Effects of Nicotinamide Riboside on Polysomnography-Measured Sleep Structure in Healthy Adults", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Eye & ENT Hospital of Fudan University", "sponsorKey": "eye & ent hospital of fudan university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Volunteers" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-12-20", "primaryCompletionDate": "2026-12-30", "lastUpdateDate": "2025-12-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07284225" }, { "nctId": "NCT06923618", "title": "Cancer of the Lung And SeneScencE - Prospective Cohort 1", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Assistance Publique - Hôpitaux de Paris", "sponsorKey": "assistance publique - hôpitaux de paris", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Non-Small Cell Lung Cancer" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-07-09", "primaryCompletionDate": "2028-07", "lastUpdateDate": "2025-12-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06923618" }, { "nctId": "NCT06799195", "title": "Optimizing GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Nebraska", "sponsorKey": "university of nebraska", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hematological Malignancies", "Graft-versus-Host Disease (GVHD)" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2025-06-23", "primaryCompletionDate": "2031-04", "lastUpdateDate": "2025-12-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06799195" }, { "nctId": "NCT06135870", "title": "Role of Senescent Cells in Uterine Fibroid Pathogenesis (SOUL Study)", "status": "RECRUITING", "phases": [], "sponsor": "Johns Hopkins University", "sponsorKey": "johns hopkins university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Fibroid", "Leiomyoma" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-11-01", "primaryCompletionDate": "2027-12-31", "lastUpdateDate": "2025-12-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06135870" }, { "nctId": "NCT04752293", "title": "Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)", "status": "RECRUITING", "phases": [], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension", "Left Ventricular Hypertrophy", "Left Ventricular Dysfunction", "Left Atrial Dilatation", "Left Ventricular Diastolic Dysfunction", "Kidney Diseases", "Kidney Injury", "Kidney Dysfunction", "Sodium Urine High", "Blood Pressure Disorders", "Uric Acid Retention", "Angiotensin Hypertension", "Autonomic Dysfunction", "Autonomic Imbalance", "Pediatric Kidney Disease", "Pediatric Obesity", "Proteinuria", "Albuminuria" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-05-19", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2025-12-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04752293" }, { "nctId": "NCT07270120", "title": "Senolytics for Secondary Progressive MS", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Ohio State University", "sponsorKey": "ohio state university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multiple Sclerosis (MS) Secondary Progressive" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2026-01-15", "primaryCompletionDate": "2027-01-15", "lastUpdateDate": "2025-12-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07270120" }, { "nctId": "NCT03107884", "title": "Role of Metformin on Muscle Health of Older Adults", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "University of Utah", "sponsorKey": "university of utah", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Muscle Atrophy", "Insulin Resistance" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-08-01", "primaryCompletionDate": "2026-11-01", "lastUpdateDate": "2025-12-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03107884" }, { "nctId": "NCT06185179", "title": "Metformin and Muscle Recovery", "status": "RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "University of Utah", "sponsorKey": "university of utah", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Muscle Atrophy or Weakness" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2024-09-01", "primaryCompletionDate": "2029-05-31", "lastUpdateDate": "2025-12-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06185179" }, { "nctId": "NCT05194397", "title": "Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Children's Hospital of Philadelphia", "sponsorKey": "children's hospital of philadelphia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Lymphoblastic Leukemia", "Cancer Survivors", "Aplastic Anemia", "Myelodysplastic Syndromes", "Myeloid Leukemia" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-02-23", "primaryCompletionDate": "2026-06-30", "lastUpdateDate": "2025-12-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05194397" }, { "nctId": "NCT06686680", "title": "Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Spaulding Rehabilitation Hospital", "sponsorKey": "spaulding rehabilitation hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Knee Osteoarthristis", "ACL Injuries", "Post-Traumatic" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-04-01", "primaryCompletionDate": "2026-07", "lastUpdateDate": "2025-12-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06686680" }, { "nctId": "NCT05617508", "title": "N-DOSE AD: A Dose Optimization Trial of Nicotinamide Riboside in Alzheimer's Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease", "Dementia" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-11-22", "primaryCompletionDate": "2025-06-05", "lastUpdateDate": "2025-12-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05617508" }, { "nctId": "NCT07251608", "title": "Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "ChromaDex", "sponsorKey": "chromadex", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "CDXC", "tickerCompany": "ChromaDex Corp", "listingStatus": "ticker", "conditions": [ "Healthy Volunteer", "Fatigue" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-10-01", "primaryCompletionDate": "2026-02-15", "lastUpdateDate": "2025-11-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07251608" }, { "nctId": "NCT06410352", "title": "Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "University Medical Center, Kazakhstan", "sponsorKey": "university medical center, kazakhstan", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Metabolic Syndrome" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-03-01", "primaryCompletionDate": "2025-09-30", "lastUpdateDate": "2025-11-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06410352" }, { "nctId": "NCT05305677", "title": "Effect of NMN (Nicotinamide Mononucleotide) on Polycystic Ovary Syndrome", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Peking University Third Hospital", "sponsorKey": "peking university third hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Polycystic Ovary Syndrome" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-06-01", "primaryCompletionDate": "2023-12-31", "lastUpdateDate": "2025-11-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05305677" }, { "nctId": "NCT06463743", "title": "Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "State University of New York at Buffalo", "sponsorKey": "state university of new york at buffalo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multiple Sclerosis" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2025-09-24", "primaryCompletionDate": "2027-01-01", "lastUpdateDate": "2025-11-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06463743" }, { "nctId": "NCT05426044", "title": "Metformin as a Neuroprotective Therapy for Glaucoma", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Christopher Kai Shun Leung", "sponsorKey": "christopher kai shun leung", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glaucoma" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2025-06-01", "primaryCompletionDate": "2027-12-31", "lastUpdateDate": "2025-11-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05426044" }, { "nctId": "NCT02582567", "title": "Effects of Exercise During Gestation on Maternal and Foetal Health", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universidad de Granada", "sponsorKey": "universidad de granada", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pregnancy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-10", "primaryCompletionDate": "2017-07", "lastUpdateDate": "2025-11-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02582567" }, { "nctId": "NCT06133634", "title": "Fisetin to Improve Vascular Function in Older Adults", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Colorado, Boulder", "sponsorKey": "university of colorado, boulder", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Endothelial Dysfunction", "Arterial Stiffness" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-09-25", "primaryCompletionDate": "2026-03-31", "lastUpdateDate": "2025-11-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06133634" }, { "nctId": "NCT05023993", "title": "The Effect of Exercise and Nicotinamide Riboside Muscle Health and Insulin Resistance in Survivors of Childhood Cancer", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "City of Hope Medical Center", "sponsorKey": "city of hope medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hematopoietic and Lymphoid Cell Neoplasm", "Malignant Solid Neoplasm", "Prediabetes" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-06-23", "primaryCompletionDate": "2026-09-21", "lastUpdateDate": "2025-11-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05023993" }, { "nctId": "NCT06567717", "title": "Zinc and Nicotinamide Riboside for Idiopathic Pulmonary Fibrosis", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Cedars-Sinai Medical Center", "sponsorKey": "cedars-sinai medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Idiopathic Pulmonary Fibrosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-11-03", "primaryCompletionDate": "2027-01", "lastUpdateDate": "2025-11-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06567717" }, { "nctId": "NCT05768945", "title": "Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Semaglutide v DPP4 Inhibitors", "status": "COMPLETED", "phases": [], "sponsor": "Brigham and Women's Hospital", "sponsorKey": "brigham and women's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-11-30", "primaryCompletionDate": "2023-07-07", "lastUpdateDate": "2025-11-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05768945" }, { "nctId": "NCT05245903", "title": "Passive Sensor Identification of Digital Biomarkers to Assess Effects of Orally Administered Nicotinamide Riboside", "status": "RECRUITING", "phases": [], "sponsor": "Mclean Hospital", "sponsorKey": "mclean hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease", "Dementia Alzheimers", "Dementia", "Cognitive Impairment", "Mild Cognitive Impairment", "Neurodegenerative Diseases", "Neurocognitive Disorders", "Neurocognitive Dysfunction", "Cognitive Dysfunction", "Mental Disorder" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-05-31", "primaryCompletionDate": "2026-05-31", "lastUpdateDate": "2025-11-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05245903" }, { "nctId": "NCT07223242", "title": "Tailored Exercise Training Study Among Adults With HFpEF", "status": "RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "HFpEF - Heart Failure With Preserved Ejection Fraction", "Diabetic Cardiomyopathies" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-02-18", "primaryCompletionDate": "2026-12-30", "lastUpdateDate": "2025-10-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07223242" }, { "nctId": "NCT07216352", "title": "Evaluate the Safety and Efficacy of a Topical Serum (AGE Serum) in Improving Visible Signs of Aging", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Goldman, Butterwick, Fitzpatrick and Groff", "sponsorKey": "goldman, butterwick, fitzpatrick and groff", "sponsorType": "other", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Laxity; Skin" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-25", "primaryCompletionDate": "2026-03-30", "lastUpdateDate": "2025-10-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07216352" }, { "nctId": "NCT05758246", "title": "Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Minnesota", "sponsorKey": "university of minnesota", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sepsis", "Acute Infection", "Organ Failure" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-08-23", "primaryCompletionDate": "2026-08-23", "lastUpdateDate": "2025-10-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05758246" }, { "nctId": "NCT04476953", "title": "COVID-FISETIN: Pilot in SARS-CoV-2 of Fisetin to Alleviate Dysfunction and Inflammation", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Covid19" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2020-08-03", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2025-10-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04476953" }, { "nctId": "NCT04742777", "title": "Effect of mTOR Inhibition & Other Metabolism Modulating Interventions on the Elderly [SubStudy Rapa & cMRI to Evaluate Cardiac Function]", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2022-02-01", "primaryCompletionDate": "2025-09-09", "lastUpdateDate": "2025-10-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04742777" }, { "nctId": "NCT03568968", "title": "A Randomized Controlled Trial of Nicotinamide Riboside Supplementation in Early Parkinson's Disease", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-05-06", "primaryCompletionDate": "2025-06-17", "lastUpdateDate": "2025-09-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03568968" }, { "nctId": "NCT07058974", "title": "A Study of Exercise and Pharmacologic Intervention on Systemic Inflammation", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Icahn School of Medicine at Mount Sinai", "sponsorKey": "icahn school of medicine at mount sinai", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Smokers", "Former Smokers" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2025-08-25", "primaryCompletionDate": "2026-07-01", "lastUpdateDate": "2025-09-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07058974" }, { "nctId": "NCT07072988", "title": "Evaluate the Benefit of Corticoid Sparing in Elderly With Generalized AntiRAch Myasthenia Gravis Treated With IV or SC Efgartigimod", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Centre Hospitalier Universitaire de Nice", "sponsorKey": "centre hospitalier universitaire de nice", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Myasthenia Gravis, Generalized" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2025-09-19", "primaryCompletionDate": "2027-10-01", "lastUpdateDate": "2025-09-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07072988" }, { "nctId": "NCT07187713", "title": "ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases", "status": "RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Ace Cells Lab", "sponsorKey": "ace cells lab", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Hypertensive Nephropathy", "Auto Immune Disorders", "Chronic Kidney Disease", "Chronc Kidney Disease Stage 5", "Chronic Kidney Disease (Stage 3-4)", "Chronic Kidney Disease (Stages 4 and 5)", "Microalbuminuria", "Diabetic Nephropathies" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-09-20", "primaryCompletionDate": "2026-08-31", "lastUpdateDate": "2025-09-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07187713" }, { "nctId": "NCT07000708", "title": "VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Charite University, Berlin, Germany", "sponsorKey": "charite university, berlin, germany", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vaccination", "Immunosenescence", "Metabolism" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-09-10", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2025-09-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07000708" }, { "nctId": "NCT07178249", "title": "Evaluating the Safety and Preliminary Efficacy of EXG202 Gene Therapy for Neovascular AMD", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Guangzhou Jiayin Biotech", "sponsorKey": "guangzhou jiayin biotech", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-10-16", "primaryCompletionDate": "2028-02-28", "lastUpdateDate": "2025-09-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07178249" }, { "nctId": "NCT06971224", "title": "NADream: Effects of Nicotinamide Adenine Dinucleotide Supplementation on Sleep Quality in Healthy Individuals", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sleep" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-10-13", "primaryCompletionDate": "2026-05-01", "lastUpdateDate": "2025-09-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06971224" }, { "nctId": "NCT06280482", "title": "Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsorKey": "the university of texas health science center, houston", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Smooth Muscle Dysfunction Syndrome (SMDS)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-03-06", "primaryCompletionDate": "2027-07-25", "lastUpdateDate": "2025-09-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06280482" }, { "nctId": "NCT07156929", "title": "Kinetics and Metabolism of Nicotinamide Provided as a Dietary Supplementation", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University Hospital Schleswig-Holstein", "sponsorKey": "university hospital schleswig-holstein", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Respiratory Infection (for Example, Pneumonia, Bronchitis)", "Respiratory Infection Virus", "Community Acquired Pneumonia (CAP)", "COPD Acute Exacerbation", "Inflammatory Bowel Disease (IBD)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-04-20", "primaryCompletionDate": "2025-05-20", "lastUpdateDate": "2025-09-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07156929" }, { "nctId": "NCT07156331", "title": "Research on Effects of Drugs on Body Composition and Function With Imaging in Diabetes", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Kristin Clemens", "sponsorKey": "kristin clemens", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-10-01", "primaryCompletionDate": "2027-10-01", "lastUpdateDate": "2025-09-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07156331" }, { "nctId": "NCT04880005", "title": "Digital Individualized and Collaborative Treatment of T2D in General Practice Based on Decision Aid", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Southern Denmark", "sponsorKey": "university of southern denmark", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes type2" ], "topics": [ "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "metformin", "glp1_aging" ], "startDate": "2021-06-01", "primaryCompletionDate": "2025-08-31", "lastUpdateDate": "2025-09-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04880005" }, { "nctId": "NCT06852014", "title": "Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud", "sponsorKey": "fundación pública andaluza para la investigación de málaga en biomedicina y salud", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pancreatic Cancer, Adult", "Cephalic Duodenopancreatectomy" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2025-05-29", "primaryCompletionDate": "2026-06-01", "lastUpdateDate": "2025-09-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06852014" }, { "nctId": "NCT05897398", "title": "SEMASEARCH, Retrospective/Prospective Cohort Nested at ATUc/AP2 WEGOVY®", "status": "COMPLETED", "phases": [], "sponsor": "Hospices Civils de Lyon", "sponsorKey": "hospices civils de lyon", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Bariatric Surgery", "Binge Eating Disorder", "Syndromic Obesity", "Sarcopenic Obesity", "Iatrogenic Obesity", "Psychotropic Drugs" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-06-10", "primaryCompletionDate": "2025-06-10", "lastUpdateDate": "2025-09-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05897398" }, { "nctId": "NCT07024966", "title": "Effect of the Combination of Pterostilbene Cocrystal With Silybin and Nicotinamide Riboside on Exercise-Induced Oxidative Stress", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Fundació Eurecat", "sponsorKey": "fundació eurecat", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Oxidative Stress", "Physical Activity", "Antioxidant Effect" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-08-01", "primaryCompletionDate": "2025-11", "lastUpdateDate": "2025-08-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07024966" }, { "nctId": "NCT07143331", "title": "A Phase 1 Study to Assess the Safety and Effects of Single and Multiple Doses of KS101 in Healthy Volunteers", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Klotho Sciences Australia Pty", "sponsorKey": "klotho sciences australia pty", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Healthy Participants", "Alzheimer Disease", "Chronic Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-08-30", "primaryCompletionDate": "2026-04-01", "lastUpdateDate": "2025-08-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07143331" }, { "nctId": "NCT04537299", "title": "COVID-FIS: Pilot in COVID-19 (SARS-CoV-2) of Fisetin in Older Adults in Nursing Homes", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Covid19", "SARS-CoV Infection" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-04-29", "primaryCompletionDate": "2024-08-31", "lastUpdateDate": "2025-08-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04537299" }, { "nctId": "NCT05500170", "title": "Benefits of Nicotinamide Riboside Upon Cognition and Sleep", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "State University of New York at Buffalo", "sponsorKey": "state university of new york at buffalo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cognitive Impairment", "Sleep Quality" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-04-04", "primaryCompletionDate": "2027-08-30", "lastUpdateDate": "2025-08-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05500170" }, { "nctId": "NCT05536973", "title": "Safety and Efficacy of ADVM-022 in Treatment-Experienced Patients With Neovascular Age-related Macular Degeneration [LUNA]", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2022-08-23", "primaryCompletionDate": "2024-08-26", "lastUpdateDate": "2025-08-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05536973" }, { "nctId": "NCT06859515", "title": "A Long-term Follow up Study of EXG102-031 in Participants With wAMD", "status": "RECRUITING", "phases": [], "sponsor": "Guangzhou Jiayin Biotech", "sponsorKey": "guangzhou jiayin biotech", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-03-13", "primaryCompletionDate": "2030-05-15", "lastUpdateDate": "2025-08-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06859515" }, { "nctId": "NCT05033054", "title": "Effect of SGLT2i on Cardiovascular Biomarkers in Patients With Type 2 Diabetes and CKD Stage 3b-4", "status": "COMPLETED", "phases": [], "sponsor": "University of Texas Southwestern Medical Center", "sponsorKey": "university of texas southwestern medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Disease, Chronic", "Diabetes" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-01-01", "primaryCompletionDate": "2025-01-02", "lastUpdateDate": "2025-08-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05033054" }, { "nctId": "NCT02570672", "title": "Metformin for Preventing Frailty in High-risk Older Adults", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-04", "primaryCompletionDate": "2024-02-07", "lastUpdateDate": "2025-08-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02570672" }, { "nctId": "NCT04809974", "title": "Clinical Trial of Niagen to Examine Recovery in People With Persistent Cognitive and Physical Symptoms After COVID-19", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Massachusetts General Hospital", "sponsorKey": "massachusetts general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Covid19", "Sequelae of; Infection", "Cognitive Symptom" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-08-28", "primaryCompletionDate": "2023-10-05", "lastUpdateDate": "2025-08-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04809974" }, { "nctId": "NCT06776510", "title": "A Clinical Study of NAD in the Treatment of Immune Thrombocytopenia", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Institute of Hematology & Blood Diseases Hospital, China", "sponsorKey": "institute of hematology & blood diseases hospital, china", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Immune Thrombocytopenia", "Treatment" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-01-15", "primaryCompletionDate": "2025-12-01", "lastUpdateDate": "2025-08-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06776510" }, { "nctId": "NCT04112641", "title": "NIAGEN and Persistent Chemotherapy-Induced Peripheral Neuropathy", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Donna Hammond, PhD", "sponsorKey": "donna hammond, phd", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chemotherapy-induced Peripheral Neuropathy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-02-19", "primaryCompletionDate": "2026-06-28", "lastUpdateDate": "2025-07-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04112641" }, { "nctId": "NCT07092618", "title": "Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation", "status": "RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "AgelessRx", "sponsorKey": "agelessrx", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Longevity", "GLP-1", "Geroscience", "Aging" ], "topics": [ "Rapamycin", "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "rapamycin", "metformin", "glp1_aging" ], "startDate": "2024-12-17", "primaryCompletionDate": "2025-08", "lastUpdateDate": "2025-07-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07092618" }, { "nctId": "NCT07092605", "title": "Effectiveness of Microdosed GLP-1 in Improving Health, Quality of Life, and Longevity Measures", "status": "ENROLLING_BY_INVITATION", "phases": [ "EARLY_PHASE1" ], "sponsor": "AgelessRx", "sponsorKey": "agelessrx", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Longevity", "Quality of Life", "Mood", "Inflammation", "Immune Health", "Pain Management", "Weight Management", "Alertness" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2024-11-01", "primaryCompletionDate": "2025-11-01", "lastUpdateDate": "2025-07-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07092605" }, { "nctId": "NCT05243290", "title": "Nicotinamide Riboside Clinical Trial for GWI", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Roskamp Institute", "sponsorKey": "roskamp institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Gulf War Illness" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-04-13", "primaryCompletionDate": "2025-04-30", "lastUpdateDate": "2025-07-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05243290" }, { "nctId": "NCT06211556", "title": "Depletion of Liver Fat in Type 2 Diabetes", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Rigshospitalet, Denmark", "sponsorKey": "rigshospitalet, denmark", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type2diabetes", "Obesity" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-02-01", "primaryCompletionDate": "2026-03", "lastUpdateDate": "2025-07-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06211556" }, { "nctId": "NCT07073352", "title": "ACEs, SIRT1, and Premature Vascular Aging in Humans", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Nathaniel Jenkins", "sponsorKey": "nathaniel jenkins", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Adverse Childhood Experiences", "Endothelial Dysfunction" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-03-27", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2025-07-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07073352" }, { "nctId": "NCT06425042", "title": "Nicotinamide Riboside Supplementation and Exercise Training to Promote Healthy Longevity", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Finis Terrae University", "sponsorKey": "finis terrae university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Aging", "Lifestyle-related Condition", "Metabolic Diseases" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-03-01", "primaryCompletionDate": "2025-12", "lastUpdateDate": "2025-07-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06425042" }, { "nctId": "NCT05589766", "title": "N-DOSE: A Dose Optimization Trial of Nicotinamide Riboside in Parkinson's Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-01-23", "primaryCompletionDate": "2025-04-22", "lastUpdateDate": "2025-07-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05589766" }, { "nctId": "NCT06907329", "title": "The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Qing Su", "sponsorKey": "qing su", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Immunosenescence", "Metabolism" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-06-05", "primaryCompletionDate": "2027-03-31", "lastUpdateDate": "2025-07-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06907329" }, { "nctId": "NCT06889740", "title": "Evaluate the Safety, Tolerability, and Efficacy of UthPeak NMNH (Reduced Nicotinamide Mononucleotide) in Healthy Adult Participants", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "EffePharm", "sponsorKey": "effepharm", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-07-08", "primaryCompletionDate": "2024-12-08", "lastUpdateDate": "2025-07-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06889740" }, { "nctId": "NCT04166396", "title": "Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Virginia Commonwealth University", "sponsorKey": "virginia commonwealth university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cystic Fibrosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-02-17", "primaryCompletionDate": "2024-07-30", "lastUpdateDate": "2025-07-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04166396" }, { "nctId": "NCT06022068", "title": "Evaluating Rapamycin Treatment in Alzheimer's Disease Using Positron Emission Tomography", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Karolinska Institutet", "sponsorKey": "karolinska institutet", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2023-09-01", "primaryCompletionDate": "2024-12-11", "lastUpdateDate": "2025-07-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06022068" }, { "nctId": "NCT06198413", "title": "LX102 in Patients With Neovascular Age-Related Macular Degeneration (nAMD)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Innostellar Biotherapeutics", "sponsorKey": "innostellar biotherapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-02-27", "primaryCompletionDate": "2024-12-26", "lastUpdateDate": "2025-07-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06198413" }, { "nctId": "NCT06991712", "title": "Comparisons of NAD Precursors for Neuroenhancement in Glaucoma Patients", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Christopher Kai Shun Leung", "sponsorKey": "christopher kai shun leung", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glaucoma" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-05-19", "primaryCompletionDate": "2025-12-31", "lastUpdateDate": "2025-06-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06991712" }, { "nctId": "NCT05324085", "title": "Aerobic Exercise for Cognitive Functioning in Patients With Substance Use Disorder", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "St. Olavs Hospital", "sponsorKey": "st. olavs hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Substance Abuse", "Cognitive Dysfunction" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-04-07", "primaryCompletionDate": "2024-12-20", "lastUpdateDate": "2025-06-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05324085" }, { "nctId": "NCT03920982", "title": "Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Centre Hospitalier Universitaire, Amiens", "sponsorKey": "centre hospitalier universitaire, amiens", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Acute Kidney Injury", "Septic Shock", "Uremic; Toxemia", "Mortality" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-12-10", "primaryCompletionDate": "2023-04-01", "lastUpdateDate": "2025-06-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03920982" }, { "nctId": "NCT07011225", "title": "Effects of Rehabilitation and Supplementation With Hydrolyzed Collagen vs. Whey Protein on the Cardiopulmonary, Renal, Muscular, and Immunohematological Response of COPD Patients", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Federal University of São Paulo", "sponsorKey": "federal university of são paulo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Collagen Supplementation", "Whey Protein", "Pulmonary Rehabilitation", "COPD - Chronic Obstructive Pulmonary Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-08-26", "primaryCompletionDate": "2024-12-20", "lastUpdateDate": "2025-06-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07011225" }, { "nctId": "NCT07006194", "title": "Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Università degli Studi 'G. d'Annunzio' Chieti e Pescara", "sponsorKey": "università degli studi 'g. d'annunzio' chieti e pescara", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glaucoma" ], "topics": [ "Senolytics", "NAD+/NMN" ], "topicKeys": [ "senolytics", "nad_nmn" ], "startDate": "2025-10-01", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2025-06-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT07006194" }, { "nctId": "NCT06193252", "title": "Slow-SPEED-NL: Slowing Parkinson's Early Through Exercise Dosage-Netherlands", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Radboud University Medical Center", "sponsorKey": "radboud university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease", "Prodromal Stage", "Neurodegenerative Diseases", "Parkinsonian Disorders", "REM Sleep Behavior Disorder", "Basal Ganglia Diseases", "Central Nervous System Diseases", "Synucleinopathies", "Nervous System Diseases", "Cerebral Disorder", "Brain Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-01-15", "primaryCompletionDate": "2027-12-01", "lastUpdateDate": "2025-06-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06193252" }, { "nctId": "NCT06999343", "title": "Exploring the Anti-ageing Effects of Metformin in COPD", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE3" ], "sponsor": "Fundación Instituto de Investigación Sanitaria de Navarra", "sponsorKey": "fundación instituto de investigación sanitaria de navarra", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "COPD" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2025-09-01", "primaryCompletionDate": "2029-05-01", "lastUpdateDate": "2025-05-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06999343" }, { "nctId": "NCT05546567", "title": "NOPARK Open Label Extension Study", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Safety Issues" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-09-28", "primaryCompletionDate": "2025-06-20", "lastUpdateDate": "2025-05-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05546567" }, { "nctId": "NCT05775211", "title": "Effects of Intrauterine Administration of Autologous PBMC Modulated With IFNt on Endometrial Cell Populations", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Nadezhda Women's Health Hospital", "sponsorKey": "nadezhda women's health hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-03-13", "primaryCompletionDate": "2026-03-14", "lastUpdateDate": "2025-05-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05775211" }, { "nctId": "NCT05421364", "title": "Effects of Intrauterine Administration of Autologous PBMC on the Endometrial Cells Populations", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Nadezhda Women's Health Hospital", "sponsorKey": "nadezhda women's health hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Female Infertility" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-12-09", "primaryCompletionDate": "2026-01-03", "lastUpdateDate": "2025-05-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05421364" }, { "nctId": "NCT05099094", "title": "VEGFA-targeting Gene Therapy to Treat Retinal and Choroidal Neovascularization Diseases", "status": "UNKNOWN", "phases": [ "EARLY_PHASE1" ], "sponsor": "Shanghai BDgene", "sponsorKey": "shanghai bdgene", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-related Macular Degeneration", "Diabetic Macular Edema", "Retinal Vein Occlusion" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2021-11-25", "primaryCompletionDate": "2024-11-30", "lastUpdateDate": "2025-05-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05099094" }, { "nctId": "NCT06971029", "title": "IMPACT OF SUPPLEMENTATION WITH LOW MOLECULAR WEIGHT HYDROLYZED COLLAGEN AND VERISOL ON THE EXPRESSION OF LINES, SKIN QUALITY, AND LEVELS OF KLOTHO, VEGF, AND TGF-BETA IN THE EYE REGION", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Federal University of São Paulo", "sponsorKey": "federal university of são paulo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Skin Health", "Collagen Supplementation", "Growth Factors" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2025-06-09", "primaryCompletionDate": "2025-09", "lastUpdateDate": "2025-05-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06971029" }, { "nctId": "NCT06966583", "title": "NAD+ Supplement（NMN）With Radioimmunotherapy in Advanced NSCLC", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Sichuan University", "sponsorKey": "sichuan university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Solid Tumor", "Non Small Cell Lung Cancer" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-05-01", "primaryCompletionDate": "2027-06-30", "lastUpdateDate": "2025-05-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06966583" }, { "nctId": "NCT05769335", "title": "Calories or Time Restriction to Alter Biomarkers of Aging and Diabetes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Adelaide", "sponsorKey": "university of adelaide", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-03-15", "primaryCompletionDate": "2024-12-10", "lastUpdateDate": "2025-05-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05769335" }, { "nctId": "NCT05505747", "title": "Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair", "status": "WITHDRAWN", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Austin V Stone", "sponsorKey": "austin v stone", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Meniscus Tear", "Meniscus; Derangement", "Meniscus Lesion", "Meniscus Disorder" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-07", "primaryCompletionDate": "2026-02", "lastUpdateDate": "2025-05-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05505747" }, { "nctId": "NCT04375657", "title": "Thymus Regeneration, Immunorestoration, and Insulin Mitigation Extension Trial", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Intervene Immune", "sponsorKey": "intervene immune", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Epigenetic Aging", "Immunosenescence" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2020-11-23", "primaryCompletionDate": "2025-12", "lastUpdateDate": "2025-05-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04375657" }, { "nctId": "NCT06882096", "title": "Tracing the Metabolic Flux of Orally Administered NAD+ Precursors", "status": "RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Metro International Biotech", "sponsorKey": "metro international biotech", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Adults" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-04-28", "primaryCompletionDate": "2026-12", "lastUpdateDate": "2025-05-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06882096" }, { "nctId": "NCT05786521", "title": "Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Diabetes Mellitus, Type 2", "PreDiabetes", "Overweight and Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-04-01", "primaryCompletionDate": "2024-05-20", "lastUpdateDate": "2025-05-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05786521" }, { "nctId": "NCT06953518", "title": "An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Qualia Life Sciences", "sponsorKey": "qualia life sciences", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Inflammation" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-05-12", "primaryCompletionDate": "2025-05-18", "lastUpdateDate": "2025-05-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06953518" }, { "nctId": "NCT06950736", "title": "NR vs. Vitamin E in Enhancing Fertility", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "The First Affiliated Hospital of Zhengzhou University", "sponsorKey": "the first affiliated hospital of zhengzhou university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility Female" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-05-05", "primaryCompletionDate": "2026-04-01", "lastUpdateDate": "2025-04-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06950736" }, { "nctId": "NCT05517122", "title": "Effect of Oral NAD+ Precursors Administration on Blood NAD+ Concentration in Healthy Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Société des Produits Nestlé (SPN)", "sponsorKey": "société des produits nestlé (spn)", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "NESN.SW", "tickerCompany": "Nestle SA (Societe des Produits Nestle)", "listingStatus": "ticker", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-07-12", "primaryCompletionDate": "2022-11-24", "lastUpdateDate": "2025-04-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05517122" }, { "nctId": "NCT05302596", "title": "Semaglutide Use in Elderly Obese Patients", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "State University of New York at Buffalo", "sponsorKey": "state university of new york at buffalo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Aging" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-09-01", "primaryCompletionDate": "2023-10-23", "lastUpdateDate": "2025-04-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05302596" }, { "nctId": "NCT05882214", "title": "Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge Drink", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Zhejiang Chinese Medical University", "sponsorKey": "zhejiang chinese medical university", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Binge Drinking", "Liver Injury", "Nutritional Supplementation", "Hepatic Steatosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-05-01", "primaryCompletionDate": "2025-02-18", "lastUpdateDate": "2025-04-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05882214" }, { "nctId": "NCT05414292", "title": "Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University of Nottingham", "sponsorKey": "university of nottingham", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Muscle Atrophy", "Age-Related Sarcopenia" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2021-08-06", "primaryCompletionDate": "2027-05-01", "lastUpdateDate": "2025-04-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05414292" }, { "nctId": "NCT06919328", "title": "Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Nutraceuticals Research Institute", "sponsorKey": "nutraceuticals research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-10-31", "primaryCompletionDate": "2025-04-30", "lastUpdateDate": "2025-04-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06919328" }, { "nctId": "NCT03482167", "title": "NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Delaware", "sponsorKey": "university of delaware", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-03-20", "primaryCompletionDate": "2024-01-08", "lastUpdateDate": "2025-04-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03482167" }, { "nctId": "NCT06889142", "title": "Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "TriHealth", "sponsorKey": "trihealth", "sponsorType": "industry", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Human Immunodeficiency Virus" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-04", "primaryCompletionDate": "2025-07", "lastUpdateDate": "2025-04-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06889142" }, { "nctId": "NCT04132492", "title": "AGNES - Aging Nephropathy Study, a Prospective Observational Cohort of Chronic Kidney Disease in Elderly Patients", "status": "COMPLETED", "phases": [], "sponsor": "University of Sao Paulo General Hospital", "sponsorKey": "university of sao paulo general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Diseases", "Elderly", "Mortality", "Renal Replacement Therapy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-09-01", "primaryCompletionDate": "2024-12-30", "lastUpdateDate": "2025-04-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04132492" }, { "nctId": "NCT05601271", "title": "Effect of Allopurinol on Markers of Mineral and Bone Metabolism", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Sao Paulo General Hospital", "sponsorKey": "university of sao paulo general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Diseases", "Osteodystrophy", "Uric Acid Concentration, Serum, Quantitative Trait Locus 7" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-03-01", "primaryCompletionDate": "2025-03-01", "lastUpdateDate": "2025-04-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05601271" }, { "nctId": "NCT03585556", "title": "AAVCAGsCD59 for the Treatment of Wet AMD", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Janssen Research & Development", "sponsorKey": "janssen research & development", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "JNJ", "tickerCompany": "Johnson & Johnson (Janssen)", "listingStatus": "ticker", "conditions": [ "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2018-09-13", "primaryCompletionDate": "2020-01-29", "lastUpdateDate": "2025-03-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03585556" }, { "nctId": "NCT03144999", "title": "Treatment of Advanced Dry Age Related Macular Degeneration With AAVCAGsCD59", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Janssen Research & Development", "sponsorKey": "janssen research & development", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "JNJ", "tickerCompany": "Johnson & Johnson (Janssen)", "listingStatus": "ticker", "conditions": [ "Dry Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2017-03-29", "primaryCompletionDate": "2017-12-06", "lastUpdateDate": "2025-03-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03144999" }, { "nctId": "NCT04528004", "title": "Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "University of Washington", "sponsorKey": "university of washington", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure, Systolic", "Heart Failure NYHA Class IV", "Metabolic Disturbance" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-09-26", "primaryCompletionDate": "2024-11-30", "lastUpdateDate": "2025-03-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04528004" }, { "nctId": "NCT06888492", "title": "To Evaluate the Safety and Preliminary Efficacy of Intravitreal EXG202 Injection in Patients with Wet (neovascular) Age-related Macular Degeneration (wAMD)", "status": "NOT_YET_RECRUITING", "phases": [ "EARLY_PHASE1" ], "sponsor": "Guangzhou Jiayin Biotech", "sponsorKey": "guangzhou jiayin biotech", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Wet Age-related Macular Degeneration (wAMD)", "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2025-03-28", "primaryCompletionDate": "2026-04-25", "lastUpdateDate": "2025-03-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06888492" }, { "nctId": "NCT06459310", "title": "Pilot Study on Evaluating the Geroprotective Effect of Metformin", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Xuanwu Hospital, Beijing", "sponsorKey": "xuanwu hospital, beijing", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Metformin", "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2024-06-30", "primaryCompletionDate": "2026-09-30", "lastUpdateDate": "2025-03-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06459310" }, { "nctId": "NCT05095571", "title": "A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Amyotrophic Lateral Sclerosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-10-07", "primaryCompletionDate": "2025-12-31", "lastUpdateDate": "2025-03-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05095571" }, { "nctId": "NCT06853743", "title": "The NAD-HD Study: A Study to Investigate Efficacy and Safety of Nicotinamide Riboside Compared With Placebo in Huntington's Disease", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Oslo University Hospital", "sponsorKey": "oslo university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Huntington Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-03-18", "primaryCompletionDate": "2029-03", "lastUpdateDate": "2025-03-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06853743" }, { "nctId": "NCT05422885", "title": "Safety and Feasibility of Dasatinib and Quercetin in Adults at Risk for Alzheimer's Disease", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Lewis Lipsitz", "sponsorKey": "lewis lipsitz", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-05-20", "primaryCompletionDate": "2024-01-24", "lastUpdateDate": "2025-03-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05422885" }, { "nctId": "NCT05777954", "title": "Klotho and Mineral Bone Density in Systemic Sclerosis", "status": "COMPLETED", "phases": [], "sponsor": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS", "sponsorKey": "fondazione policlinico universitario agostino gemelli irccs", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Systemic Sclerosis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-03-21", "primaryCompletionDate": "2024-04-30", "lastUpdateDate": "2025-03-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05777954" }, { "nctId": "NCT03721497", "title": "Testosterone in Bariatric Patients", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "Esbjerg Hospital - University Hospital of Southern Denmark", "sponsorKey": "esbjerg hospital - university hospital of southern denmark", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Bariatric Surgery Candidate", "Male Hypogonadism", "Muscle Loss" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2020-12-17", "primaryCompletionDate": "2025-12", "lastUpdateDate": "2025-03-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03721497" }, { "nctId": "NCT04906057", "title": "The Therapeutic Effects of Forced Aerobic Exercise in Multiple Sclerosis", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "The Cleveland Clinic", "sponsorKey": "the cleveland clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multiple Sclerosis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-07-06", "primaryCompletionDate": "2022-11-29", "lastUpdateDate": "2025-03-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04906057" }, { "nctId": "NCT03310684", "title": "Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)", "status": "COMPLETED", "phases": [], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pediatric Disorder", "Pediatric Obesity", "Primary Hypertension" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-12-03", "primaryCompletionDate": "2023-04-26", "lastUpdateDate": "2025-02-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03310684" }, { "nctId": "NCT06280560", "title": "Impact of IVF Hormonal Therapy on Endometrial Receptivity and Endometrial Senescent Cell Pathological Accumulation", "status": "RECRUITING", "phases": [], "sponsor": "Fundación IVI", "sponsorKey": "fundación ivi", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Endometrial Receptivity" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-02-01", "primaryCompletionDate": "2025-12-30", "lastUpdateDate": "2025-02-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06280560" }, { "nctId": "NCT03818802", "title": "Effects of Vitamin B3 Derivative Nicotinamide Riboside (NR) in Bone, Skeletal Muscle and Metabolic Functions in Aging", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Elderly Volunteers" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-09-16", "primaryCompletionDate": "2024-11-08", "lastUpdateDate": "2025-02-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03818802" }, { "nctId": "NCT05755997", "title": "CERebrolysin In CADASIL", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Ever Neuro Pharma", "sponsorKey": "ever neuro pharma", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Cadasil" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-11-29", "primaryCompletionDate": "2026-03-31", "lastUpdateDate": "2025-02-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05755997" }, { "nctId": "NCT03821623", "title": "Nicotinamide Riboside for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Middle-aged and Older Adults", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Douglas Seals", "sponsorKey": "douglas seals", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension", "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-05-10", "primaryCompletionDate": "2025-06-01", "lastUpdateDate": "2025-02-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03821623" }, { "nctId": "NCT06295913", "title": "Hydroxytyrosol Dietary Supplement and Prevention of Age-Related Diseases", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "National Research Council, Spain", "sponsorKey": "national research council, spain", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight", "PreDiabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-12-01", "primaryCompletionDate": "2024-09-30", "lastUpdateDate": "2025-02-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06295913" }, { "nctId": "NCT06601452", "title": "Clinical Trial of Anovulatory Infertility", "status": "ENROLLING_BY_INVITATION", "phases": [ "EARLY_PHASE1" ], "sponsor": "Affiliated Hospital of Nanjing University of Chinese Medicine", "sponsorKey": "affiliated hospital of nanjing university of chinese medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Polycystic Ovary Syndrome", "Diminished Ovarian Reserve", "Ovulation Disorder" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-09-30", "primaryCompletionDate": "2028-12-31", "lastUpdateDate": "2025-02-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06601452" }, { "nctId": "NCT04330326", "title": "Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "ScandiBio Therapeutics AB", "sponsorKey": "scandibio therapeutics ab", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Non-alcoholic Fatty Liver Disease (NAFLD)" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-07-20", "primaryCompletionDate": "2020-07-29", "lastUpdateDate": "2025-02-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04330326" }, { "nctId": "NCT04573153", "title": "Metabolic Cofactor Supplementation and Hydroxychloroquine Combination in Covid-19 Patients", "status": "TERMINATED", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "ScandiBio Therapeutics AB", "sponsorKey": "scandibio therapeutics ab", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "COVID-19" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-09-21", "primaryCompletionDate": "2022-05-05", "lastUpdateDate": "2025-02-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04573153" }, { "nctId": "NCT05703074", "title": "Mental Intervention and Nicotinamide Riboside Supplementation in Long Covid", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University Hospital, Akershus", "sponsorKey": "university hospital, akershus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Long COVID" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-01-30", "primaryCompletionDate": "2024-09-23", "lastUpdateDate": "2025-02-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05703074" }, { "nctId": "NCT03173235", "title": "Plasma Concentrations of Calcium, Phosphate, FGF23, Klotho, 25 (OH) D3 and 1,25 (OH) 2D3 from Patients Who Wants to Have Children", "status": "COMPLETED", "phases": [], "sponsor": "University Hospital Tuebingen", "sponsorKey": "university hospital tuebingen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility, Female" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-08-01", "primaryCompletionDate": "2021-12-01", "lastUpdateDate": "2025-01-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03173235" }, { "nctId": "NCT06208527", "title": "The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty", "Frail Elderly Syndrome", "Frailty Syndrome", "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-01", "primaryCompletionDate": "2027-12", "lastUpdateDate": "2025-01-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06208527" }, { "nctId": "NCT05698771", "title": "NAD-brain: a Pharmacokinetic Study of NAD Replenishment Therapy", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-09-17", "primaryCompletionDate": "2024-03-04", "lastUpdateDate": "2025-01-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05698771" }, { "nctId": "NCT03743636", "title": "Nicotinamide Riboside With and Without Resveratrol to Improve Functioning in Peripheral Artery Disease", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Northwestern University", "sponsorKey": "northwestern university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Peripheral Artery Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-10-01", "primaryCompletionDate": "2023-05-23", "lastUpdateDate": "2025-01-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03743636" }, { "nctId": "NCT06770894", "title": "DPP4-Inhibitors and Bone Metabolism in Diabetes", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Azienda Policlinico Umberto I", "sponsorKey": "azienda policlinico umberto i", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteoporosis", "Bone Loss, Postmenopausal", "Diabetes Mellitus Type 2" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-09-24", "primaryCompletionDate": "2023-10-10", "lastUpdateDate": "2025-01-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06770894" }, { "nctId": "NCT06162013", "title": "The NADAPT Study: a Randomized Double-blind Trial of NAD Replenishment Therapy for Atypical Parkinsonism", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Progressive Supranuclear Palsy", "Multiple System Atrophy", "Corticobasal Syndrome" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-03-05", "primaryCompletionDate": "2028-12", "lastUpdateDate": "2025-01-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06162013" }, { "nctId": "NCT06744764", "title": "Pulsed Electromagnetic Fields in Preventing Physical Deconditioning in Patients Undergoing Prolonged Hospitalization", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "National University Hospital, Singapore", "sponsorKey": "national university hospital, singapore", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Haematological Cancer", "Healthy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-04-17", "primaryCompletionDate": "2025-12", "lastUpdateDate": "2025-01-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06744764" }, { "nctId": "NCT03746106", "title": "The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "University of California, San Francisco", "sponsorKey": "university of california, san francisco", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vitamin B1 Deficiency", "Thiamine Deficiency" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-01-28", "primaryCompletionDate": "2023-08-10", "lastUpdateDate": "2025-01-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03746106" }, { "nctId": "NCT06739720", "title": "RCT of Efficacy and Safety of CP003 on CFS/ME or Post-COVID Fatigue", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "The University of Hong Kong", "sponsorKey": "the university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Fatigue Syndrome (CFS)", "Post-COVID ME/CFS" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2025-01-02", "primaryCompletionDate": "2026-06-30", "lastUpdateDate": "2024-12-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06739720" }, { "nctId": "NCT04113122", "title": "Senescence and the Early Ageing Phenotype After Chemotherapy for Testicular Cancer: the SEA-CAT Study", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "University Medical Center Groningen", "sponsorKey": "university medical center groningen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Testicular Cancer" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2019-02-09", "primaryCompletionDate": "2026-09", "lastUpdateDate": "2024-12-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04113122" }, { "nctId": "NCT02514629", "title": "Testosterone, Metformin, or Both, for Hypogonadism in Obese Males", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud", "sponsorKey": "fundación pública andaluza para la investigación de málaga en biomedicina y salud", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypogonadism", "Obesity" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2013-07-04", "primaryCompletionDate": "2016-07-12", "lastUpdateDate": "2024-12-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02514629" }, { "nctId": "NCT02876211", "title": "Paricalcitol Improves Anemia of Inflammation", "status": "TERMINATED", "phases": [ "PHASE4" ], "sponsor": "Hospital Son Espases", "sponsorKey": "hospital son espases", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anemia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-12", "primaryCompletionDate": "2022-08", "lastUpdateDate": "2024-12-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02876211" }, { "nctId": "NCT06522074", "title": "Evaluating the Role of IGF-1 and S-Klotho In Plaque Phenotype and Vulnerability: the VISION Study.", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS", "sponsorKey": "fondazione policlinico universitario agostino gemelli irccs", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ischemic Heart Disease", "Chronic Coronary Syndrome", "Optical Coherence Tomography (OCT)" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-10-15", "primaryCompletionDate": "2026-09-30", "lastUpdateDate": "2024-12-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06522074" }, { "nctId": "NCT05608707", "title": "APPETITE: Plant Protein and Exercise Solutions for the Prevention of Undernutrition in Older Adults.", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "University College Dublin", "sponsorKey": "university college dublin", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Appetite Loss", "Physical Inactivity", "Undernutrition", "Anorexia of Aging", "Aging", "Ageing Well" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-09-22", "primaryCompletionDate": "2024-07-17", "lastUpdateDate": "2024-12-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05608707" }, { "nctId": "NCT06240403", "title": "Digoxin and Senolysis in Heart Failure and Diabetes Mellitus", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University of Leeds", "sponsorKey": "university of leeds", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure, Systolic", "Diabetes Mellitus, Type 2" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2025-09-01", "primaryCompletionDate": "2028-08-28", "lastUpdateDate": "2024-12-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06240403" }, { "nctId": "NCT04078178", "title": "Crossover Trial for Nicotinamide Riboside in Subjective Cognitive Decline and Mild Cognitive Impairment", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Steven E Arnold, MD", "sponsorKey": "steven e arnold, md", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cognition Disorders in Old Age", "Mild Cognitive Impairment", "Cognitive Decline" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-10-30", "primaryCompletionDate": "2022-09-30", "lastUpdateDate": "2024-11-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04078178" }, { "nctId": "NCT06458595", "title": "Safety and Tolerability of KH658 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Chengdu Origen Biotechnology", "sponsorKey": "chengdu origen biotechnology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2024-06-28", "primaryCompletionDate": "2026-03-31", "lastUpdateDate": "2024-11-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06458595" }, { "nctId": "NCT05672121", "title": "Safety and Tolerability of KH631 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Chengdu Origen Biotechnology", "sponsorKey": "chengdu origen biotechnology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-02-06", "primaryCompletionDate": "2026-12-28", "lastUpdateDate": "2024-11-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05672121" }, { "nctId": "NCT06450301", "title": "Senescent Endometrial Cells in Patients with Thin Endometrial Lining", "status": "RECRUITING", "phases": [], "sponsor": "Trio Fertility", "sponsorKey": "trio fertility", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Asherman's Syndrome", "Thin Endometrial Lining", "Cell Senescence" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-09-11", "primaryCompletionDate": "2027-01", "lastUpdateDate": "2024-11-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06450301" }, { "nctId": "NCT06141460", "title": "Safety and Efficacy of RRG001 Gene Therapy in Subjects With Neovascular Age-related Macular Degeneration (nAMD)", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Shanghai Refreshgene Technology", "sponsorKey": "shanghai refreshgene technology", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-12-12", "primaryCompletionDate": "2026-04-15", "lastUpdateDate": "2024-11-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06141460" }, { "nctId": "NCT06629636", "title": "Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Sunkaky Medical Cooperation", "sponsorKey": "sunkaky medical cooperation", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Repeated IVF Failure", "Female Infertility" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-08-20", "primaryCompletionDate": "2025-09-30", "lastUpdateDate": "2024-10-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06629636" }, { "nctId": "NCT06607068", "title": "Assessment of Taurine Concentration in Older Women With/Without Obesity And With/Without Type 2 Diabetes Mellitus", "status": "ACTIVE_NOT_RECRUITING", "phases": [], "sponsor": "University of Sao Paulo", "sponsorKey": "university of sao paulo", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity and Type 2 Diabetes" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2024-02-28", "primaryCompletionDate": "2024-09-05", "lastUpdateDate": "2024-09-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06607068" }, { "nctId": "NCT05175768", "title": "Study to Evaluate the Effect of Nicotinamide Mononucleotide (NMN) As an Adjuvant to Standard of Care (SOC) On Fatigue Associated With COVID-19 Infection", "status": "TERMINATED", "phases": [ "NA" ], "sponsor": "Vedic Lifesciences Pvt", "sponsorKey": "vedic lifesciences pvt", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "COVID-19 Infection" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-12-27", "primaryCompletionDate": "2022-07-16", "lastUpdateDate": "2024-09-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05175768" }, { "nctId": "NCT03727646", "title": "Nicotinamide Riboside in LVAD Recipients", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "University of Washington", "sponsorKey": "university of washington", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure，Congestive", "Heart Failure New York Heart Association Class IV", "Mitochondrial Alteration" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-09-26", "primaryCompletionDate": "2018-11-26", "lastUpdateDate": "2024-09-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03727646" }, { "nctId": "NCT04210986", "title": "Senolytic Drugs Attenuate Osteoarthritis-Related Articular Cartilage Degeneration: A Clinical Trial", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Steadman Philippon Research Institute", "sponsorKey": "steadman philippon research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteoarthritis, Knee" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2020-01-06", "primaryCompletionDate": "2023-01-05", "lastUpdateDate": "2024-09-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04210986" }, { "nctId": "NCT05724329", "title": "Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01)", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University", "sponsorKey": "sun yat-sen memorial hospital of sun yat-sen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Head and Neck Squamous Cell Carcinomas" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-02-05", "primaryCompletionDate": "2024-04-05", "lastUpdateDate": "2024-09-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05724329" }, { "nctId": "NCT04832724", "title": "RGX-314 Gene Therapy Pharmacodynamic Study for Neovascular Age-related Macular Degeneration (nAMD)", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-related Macular Degeneration", "Wet Macular Degeneration", "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2021-02-22", "primaryCompletionDate": "2023-10-02", "lastUpdateDate": "2024-09-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04832724" }, { "nctId": "NCT05550428", "title": "The Effects of Pulsed Electromagnetic Field Therapy on Patients With End-stage of Knee Osteoarthritis", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "NA" ], "sponsor": "Chinese University of Hong Kong", "sponsorKey": "chinese university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Knee Osteoarthritis", "Sarcopenia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-11-01", "primaryCompletionDate": "2025-06-01", "lastUpdateDate": "2024-08-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05550428" }, { "nctId": "NCT03713801", "title": "Impact of Metformin on Immunity", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Vaccine Response Impaired" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-01-14", "primaryCompletionDate": "2024-07-16", "lastUpdateDate": "2024-08-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03713801" }, { "nctId": "NCT06550271", "title": "The Bioavailability of Compounded and Generic Rapamycin in Normative Aging Individuals", "status": "COMPLETED", "phases": [], "sponsor": "AgelessRx", "sponsorKey": "agelessrx", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2023-04-25", "primaryCompletionDate": "2023-12-15", "lastUpdateDate": "2024-08-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06550271" }, { "nctId": "NCT06131671", "title": "Whole-body Electrostimulation on Functional Mobility and Quality of Life in the Elderly", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Federal University of Health Science of Porto Alegre", "sponsorKey": "federal university of health science of porto alegre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aged" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-01-22", "primaryCompletionDate": "2024-03-22", "lastUpdateDate": "2024-08-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06131671" }, { "nctId": "NCT06534450", "title": "The Effects Of Therapeutic Plasma Exchange (TPE) On Age Related Biomarkers And Epigenetics", "status": "UNKNOWN", "phases": [ "PHASE3" ], "sponsor": "Dobri Kiprov", "sponsorKey": "dobri kiprov", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Aging" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2022-09-12", "primaryCompletionDate": "2023-11-30", "lastUpdateDate": "2024-08-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06534450" }, { "nctId": "NCT06521307", "title": "Impact of Nicotinamide Riboside (NR) on Kidney Function in Patients Undergoing Cardiac Surgery", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Instituto Nacional de Cardiologia Ignacio Chavez", "sponsorKey": "instituto nacional de cardiologia ignacio chavez", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Acute Kidney Injury", "Cardiac Valve Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-07-24", "primaryCompletionDate": "2025-07-31", "lastUpdateDate": "2024-07-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06521307" }, { "nctId": "NCT06327503", "title": "Salivary Signal Molecules for Neural and Vascular Homeostasis in T2DM", "status": "COMPLETED", "phases": [], "sponsor": "University of Belgrade", "sponsorKey": "university of belgrade", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-04-01", "primaryCompletionDate": "2024-06-30", "lastUpdateDate": "2024-07-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06327503" }, { "nctId": "NCT04313634", "title": "Targeting Cellular Senescence With Senolytics to Improve Skeletal Health in Older Humans", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Sundeep Khosla, M.D", "sponsorKey": "sundeep khosla, m.d", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2020-06-09", "primaryCompletionDate": "2023-06-06", "lastUpdateDate": "2024-07-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04313634" }, { "nctId": "NCT06502522", "title": "Effects of Whole-body Electrostimulation on Patients With Chronic Kidney Disease", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Federal University of Health Science of Porto Alegre", "sponsorKey": "federal university of health science of porto alegre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Insufficiency, Chronic" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-08-01", "primaryCompletionDate": "2024-12-01", "lastUpdateDate": "2024-07-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06502522" }, { "nctId": "NCT04495608", "title": "Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Fluconazole in Hypercalcicuric Patients With Increased 1.25(OH) 2D Levels", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Hospices Civils de Lyon", "sponsorKey": "hospices civils de lyon", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Nephrolithiasis", "Nephrocalcinosis", "Hypercalciuria" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-01-13", "primaryCompletionDate": "2024-07-01", "lastUpdateDate": "2024-07-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04495608" }, { "nctId": "NCT06492863", "title": "Gene Therapy(FT-003) for Wet AMD", "status": "RECRUITING", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Frontera Therapeutics", "sponsorKey": "frontera therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-08-15", "primaryCompletionDate": "2024-10-15", "lastUpdateDate": "2024-07-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06492863" }, { "nctId": "NCT05348694", "title": "OsteoPreP: Food Supplements for Postmenopausal Bone Health", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "Australian Catholic University", "sponsorKey": "australian catholic university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Postmenopausal Osteopenia", "Bone Loss, Age Related", "Age-Related Sarcopenia", "Glucose Metabolism Disorders", "Age-related Cognitive Decline" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-05-01", "primaryCompletionDate": "2024-03-28", "lastUpdateDate": "2024-07-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05348694" }, { "nctId": "NCT06267378", "title": "Assessing Frailty and Its Impacts on Patients Facing Major GI Surgery", "status": "RECRUITING", "phases": [], "sponsor": "Doncaster And Bassetlaw Hospitals NHS Foundation Trust", "sponsorKey": "doncaster and bassetlaw hospitals nhs foundation trust", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Bowel Cancer" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-08-30", "primaryCompletionDate": "2024-12-01", "lastUpdateDate": "2024-07-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06267378" }, { "nctId": "NCT06489457", "title": "The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "University Medical Centre Ljubljana", "sponsorKey": "university medical centre ljubljana", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes Mellitus", "Obesity", "Functional Hypogonadism" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2020-09-20", "primaryCompletionDate": "2023-05-11", "lastUpdateDate": "2024-07-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06489457" }, { "nctId": "NCT03649698", "title": "Exercise and Nutrition for Healthy AgeiNg", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Universitaire Ziekenhuizen KU Leuven", "sponsorKey": "universitaire ziekenhuizen ku leuven", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2018-02-12", "primaryCompletionDate": "2024-12", "lastUpdateDate": "2024-06-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03649698" }, { "nctId": "NCT06478147", "title": "Effect of a Novel Protein Ingredient Combined With Oral Nutritional Supplement on Appetite in Older Adults", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "University College Dublin", "sponsorKey": "university college dublin", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Appetite Loss", "Undernutrition" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-12-02", "primaryCompletionDate": "2024-04-28", "lastUpdateDate": "2024-06-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06478147" }, { "nctId": "NCT03861767", "title": "REMAP Trial for Optimizing Surgical Outcomes at UPMC", "status": "TERMINATED", "phases": [ "PHASE3" ], "sponsor": "Matthew Neal MD", "sponsorKey": "matthew neal md", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-04-15", "primaryCompletionDate": "2022-09-23", "lastUpdateDate": "2024-06-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03861767" }, { "nctId": "NCT03733132", "title": "Metformin Effect on Brain Function in Insulin Resistant Elderly People", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance", "Obesity", "Obesity, Abdominal" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-03-15", "primaryCompletionDate": "2023-04-05", "lastUpdateDate": "2024-06-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03733132" }, { "nctId": "NCT03999801", "title": "Long-term Follow-Up Study of RGX-314 and Fellow Eye Substudy", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE2" ], "sponsor": "AbbVie", "sponsorKey": "abbvie", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ABBV", "tickerCompany": "AbbVie Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-related Macular Degeneration", "Wet Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2019-05-31", "primaryCompletionDate": "2028-12", "lastUpdateDate": "2024-06-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03999801" }, { "nctId": "NCT04037462", "title": "Induction of Sensecence Using Dexamethasone to Re-sensitize NSCLC to Anti-PD1 Therapy", "status": "TERMINATED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "VA Office of Research and Development", "sponsorKey": "va office of research and development", "sponsorType": "government", "sponsorClass": "FED", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Non-Small Cell Lung Cancer", "Immunotherapy" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-07-07", "primaryCompletionDate": "2022-02-23", "lastUpdateDate": "2024-06-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04037462" }, { "nctId": "NCT06005350", "title": "Nicotinamide Riboside Impact on Extracellular Nicotinamide Adenine Dinucleotide (NAD+)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Charite University, Berlin, Germany", "sponsorKey": "charite university, berlin, germany", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "NAD" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-11-01", "primaryCompletionDate": "2024-12-31", "lastUpdateDate": "2024-06-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06005350" }, { "nctId": "NCT03912220", "title": "Evaluation of Nicotinamide Riboside in Prevention of Small Fiber Axon Degeneration and Promotion of Nerve Regeneration", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Johns Hopkins University", "sponsorKey": "johns hopkins university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Small Fiber Neuropathy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-09-01", "primaryCompletionDate": "2023-05-01", "lastUpdateDate": "2024-06-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03912220" }, { "nctId": "NCT04112043", "title": "Nicotinamide Riboside as an Enhancer of Exercise Therapy in Hypertensive Older Adults (The NEET Trial)", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "University of Florida", "sponsorKey": "university of florida", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-07-28", "primaryCompletionDate": "2023-05-26", "lastUpdateDate": "2024-06-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04112043" }, { "nctId": "NCT06438510", "title": "The Fulness Trial (Fundus mUcosaL abLation aNd Endoscopic Sleeve Gastroplasty)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS", "sponsorKey": "fondazione policlinico universitario agostino gemelli irccs", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-10-08", "primaryCompletionDate": "2025-01-01", "lastUpdateDate": "2024-06-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06438510" }, { "nctId": "NCT06426355", "title": "The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR", "status": "RECRUITING", "phases": [ "NA" ], "sponsor": "Peking University Third Hospital", "sponsorKey": "peking university third hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diminished Ovarian Reserve" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-10-01", "primaryCompletionDate": "2026-02", "lastUpdateDate": "2024-05-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06426355" }, { "nctId": "NCT06425679", "title": "Cost-effectiveness and Efficacy of Different Physical Exercise Interventions (ExerMOT4Health)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "University of Cadiz", "sponsorKey": "university of cadiz", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Physical Inactivity", "Healthy Aging", "Older Adult" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-11-01", "primaryCompletionDate": "2025-01-30", "lastUpdateDate": "2024-05-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06425679" }, { "nctId": "NCT04110028", "title": "Nicotinamide Riboside in Hospitalized Patients", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Oslo University Hospital", "sponsorKey": "oslo university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Inflammation", "Acute Illness" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-10-01", "primaryCompletionDate": "2022-12-01", "lastUpdateDate": "2024-05-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04110028" }, { "nctId": "NCT06411366", "title": "Phase I: Safety and Efficacy of an Injectable Follistatin Plasmid Gene Therapy in Humans", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Minicircle", "sponsorKey": "minicircle", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Frailty", "Aging" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2022-08-18", "primaryCompletionDate": "2023-08-31", "lastUpdateDate": "2024-05-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06411366" }, { "nctId": "NCT06382688", "title": "IV Administration of ChromaDex's Niagen® as Compared to NAD+", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Nutraceuticals Research Institute", "sponsorKey": "nutraceuticals research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-11-13", "primaryCompletionDate": "2024-03-08", "lastUpdateDate": "2024-04-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06382688" }, { "nctId": "NCT04342975", "title": "Protection From Acute Kidney Injury (AKI) With Basis™ Treatment", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "AKI" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-12-01", "primaryCompletionDate": "2024-03-14", "lastUpdateDate": "2024-04-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04342975" }, { "nctId": "NCT06324877", "title": "Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "The University of Queensland", "sponsorKey": "the university of queensland", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ataxia Telangiectasia" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-05-01", "primaryCompletionDate": "2025-10-30", "lastUpdateDate": "2024-04-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06324877" }, { "nctId": "NCT04815902", "title": "Use of Senolytic and Anti-Fibrotic Agents to Improve the Beneficial Effect of Bone Marrow Stem Cells for Osteoarthritis", "status": "UNKNOWN", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Steadman Philippon Research Institute", "sponsorKey": "steadman philippon research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteoarthritis, Knee" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-05-18", "primaryCompletionDate": "2025-02-01", "lastUpdateDate": "2024-04-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04815902" }, { "nctId": "NCT05025956", "title": "Senolytic Agent Improve the Benefit of Platelet-Rich Plasma and Losartan", "status": "UNKNOWN", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Steadman Philippon Research Institute", "sponsorKey": "steadman philippon research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Femoroacetabular Impingement" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-10-24", "primaryCompletionDate": "2024-10-31", "lastUpdateDate": "2024-04-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05025956" }, { "nctId": "NCT05295342", "title": "The No Means No South Africa Evaluation Study", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "RTI International", "sponsorKey": "rti international", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Gender-based Violence", "Sexual Violence" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-02-16", "primaryCompletionDate": "2023-10-24", "lastUpdateDate": "2024-04-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05295342" }, { "nctId": "NCT06338306", "title": "Tacrolimus and Personalized Therapy to Prevent Acute Rejection Episodes", "status": "UNKNOWN", "phases": [], "sponsor": "Fondazione IRCCS Policlinico San Matteo di Pavia", "sponsorKey": "fondazione irccs policlinico san matteo di pavia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Transplant Failure" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2022-01-07", "primaryCompletionDate": "2022-06-30", "lastUpdateDate": "2024-04-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06338306" }, { "nctId": "NCT06352749", "title": "Face-to-face vs Online Physical Exercise in Seniors Living in Nursing Homes (ExerMOT-NH)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "University of the Basque Country (UPV/EHU)", "sponsorKey": "university of the basque country (upv/ehu)", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Physical Function", "Cognitive Decline", "Psychological Well-Being" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-03-18", "primaryCompletionDate": "2025-11-30", "lastUpdateDate": "2024-04-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06352749" }, { "nctId": "NCT06352957", "title": "Use of ETElcalcetidefor pReserving vitamiN K-dependent proteIn activiTY ITAlian Study", "status": "NOT_YET_RECRUITING", "phases": [], "sponsor": "Istituto di Fisiologia Clinica CNR", "sponsorKey": "istituto di fisiologia clinica cnr", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hemodialysis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2024-05-01", "primaryCompletionDate": "2026-12-31", "lastUpdateDate": "2024-04-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06352957" }, { "nctId": "NCT05411835", "title": "Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Oregon Health and Science University", "sponsorKey": "oregon health and science university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency", "Carnitine Palmitoyltransferase Deficiency 2", "Very Long Chain Acyl Coa Dehydrogenase Deficiency", "Trifunctional Protein Deficiency" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-08-01", "primaryCompletionDate": "2023-01-31", "lastUpdateDate": "2024-04-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05411835" }, { "nctId": "NCT05481827", "title": "ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent Study", "status": "ENROLLING_BY_INVITATION", "phases": [ "PHASE2" ], "sponsor": "Gyroscope Therapeutics", "sponsorKey": "gyroscope therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Age Related Macular Degeneration (AMD)" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2022-07-12", "primaryCompletionDate": "2028-06-02", "lastUpdateDate": "2024-03-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05481827" }, { "nctId": "NCT04990869", "title": "Inflammation in COPD and the Effect of Nicotinamide Riboside", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "COPD" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-08-05", "primaryCompletionDate": "2022-08-18", "lastUpdateDate": "2024-03-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04990869" }, { "nctId": "NCT03151707", "title": "The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics", "status": "TERMINATED", "phases": [ "PHASE4" ], "sponsor": "Mclean Hospital", "sponsorKey": "mclean hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2017-10-01", "primaryCompletionDate": "2022-09-30", "lastUpdateDate": "2024-03-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03151707" }, { "nctId": "NCT05443711", "title": "Sarcopenic Obesity as a Risk of Premature Aging", "status": "UNKNOWN", "phases": [], "sponsor": "Hospital de Leon", "sponsorKey": "hospital de leon", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Sarcopenic Obesity", "Aging" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-01-19", "primaryCompletionDate": "2024-12-05", "lastUpdateDate": "2024-02-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05443711" }, { "nctId": "NCT06234436", "title": "Plasma Dilution and Infusion to Improve Cognition in Mild Cognitive Impairment (MCI)", "status": "UNKNOWN", "phases": [ "EARLY_PHASE1" ], "sponsor": "Oslo University Hospital", "sponsorKey": "oslo university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2023-12-07", "primaryCompletionDate": "2024-12-31", "lastUpdateDate": "2024-01-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06234436" }, { "nctId": "NCT04488601", "title": "Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "AgelessRx", "sponsorKey": "agelessrx", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2020-01-01", "primaryCompletionDate": "2023-12-30", "lastUpdateDate": "2024-01-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04488601" }, { "nctId": "NCT06214078", "title": "Preliminary Clinical Study of NMN Intervention in Mild Ulcerative Colitis", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "The Third Xiangya Hospital of Central South University", "sponsorKey": "the third xiangya hospital of central south university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ulcerative Colitis Chronic Mild" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2024-02-01", "primaryCompletionDate": "2025-03-01", "lastUpdateDate": "2024-01-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06214078" }, { "nctId": "NCT04664361", "title": "Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Seneque", "sponsorKey": "seneque", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Physical Activity", "Muscle Recovery" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-03-09", "primaryCompletionDate": "2022-11-10", "lastUpdateDate": "2024-01-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04664361" }, { "nctId": "NCT05740722", "title": "Nicotinamide Riboside Supplementation In Progressive Multiple Sclerosis", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multiple Sclerosis", "Progressive Multiple Sclerosis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-05-03", "primaryCompletionDate": "2027-08-01", "lastUpdateDate": "2024-01-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05740722" }, { "nctId": "NCT04271735", "title": "Pilot Study to Evaluate the Effect of Nicotinamide Riboside on Immune Activation in Psoriasis", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Psoriasis", "Atherosclerotic Cardiovascular Disease", "Obesity", "Dyslipidemia", "Cardiometabolic Diseases" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-08-26", "primaryCompletionDate": "2022-12-19", "lastUpdateDate": "2023-12-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04271735" }, { "nctId": "NCT04818216", "title": "Nicotinamide Riboside in SARS-CoV-2 (COVID-19) Patients for Renal Protection", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "SARS-CoV-2 Infection", "Acute Kidney Injury" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-06-11", "primaryCompletionDate": "2021-12-09", "lastUpdateDate": "2023-12-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04818216" }, { "nctId": "NCT05548712", "title": "The Effect of PEMF for Patients With Knee OA", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Chinese University of Hong Kong", "sponsorKey": "chinese university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Knee Osteoarthritis", "Knee Pain Chronic" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-05-05", "primaryCompletionDate": "2024-09-15", "lastUpdateDate": "2023-12-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05548712" }, { "nctId": "NCT05184023", "title": "The Effect of PEMF for Patients With Quadriceps Muscle Weakness After ACLR", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Chinese University of Hong Kong", "sponsorKey": "chinese university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anterior Cruciate Ligament Injuries", "Quadriceps Muscle Atrophy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-09-01", "primaryCompletionDate": "2025-09-01", "lastUpdateDate": "2023-12-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05184023" }, { "nctId": "NCT03309007", "title": "A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "University of New Mexico", "sponsorKey": "university of new mexico", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "PreDiabetes", "Aging" ], "topics": [ "Rapamycin", "Metformin / TAME" ], "topicKeys": [ "rapamycin", "metformin" ], "startDate": "2017-09-01", "primaryCompletionDate": "2020-08-20", "lastUpdateDate": "2023-12-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03309007" }, { "nctId": "NCT02642094", "title": "Aging Mammary Stem Cells and Breast Cancer Prevention", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "LuZhe Sun", "sponsorKey": "luzhe sun", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cancer of Breast" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2016-07", "primaryCompletionDate": "2022-03-01", "lastUpdateDate": "2023-12-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02642094" }, { "nctId": "NCT04936282", "title": "Treatment of Early Borderline Lesions in Low Immunological Risk Kidney Transplant Patients (TRAINING)", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "Fundación Canaria Instituto de Investigación Sanitaria de Canarias", "sponsorKey": "fundación canaria instituto de investigación sanitaria de canarias", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Transplant Failure and Rejection" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-07-05", "primaryCompletionDate": "2024-06", "lastUpdateDate": "2023-12-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04936282" }, { "nctId": "NCT05173194", "title": "Remotely Supervised Exercise for Adults With Cystic Fibrosis", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universidad Europea de Madrid", "sponsorKey": "universidad europea de madrid", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cystic Fibrosis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-10-26", "primaryCompletionDate": "2021-12-30", "lastUpdateDate": "2023-12-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05173194" }, { "nctId": "NCT04273490", "title": "Characterising Pain, QoL, Body Composition, Arterial Stiffness, Muscles and Bones in Adult Persons With XLH and Healthy Controls", "status": "COMPLETED", "phases": [], "sponsor": "University of Aarhus", "sponsorKey": "university of aarhus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "X-linked Hypophosphatemia", "Hereditary Hypophosphatemia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2020-02-18", "primaryCompletionDate": "2022-12-20", "lastUpdateDate": "2023-11-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04273490" }, { "nctId": "NCT05871060", "title": "Effect of a Novel Protein Supplement on Appetite in Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University College Dublin", "sponsorKey": "university college dublin", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Appetite Loss" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2023-04-25", "primaryCompletionDate": "2023-09-15", "lastUpdateDate": "2023-11-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05871060" }, { "nctId": "NCT06136013", "title": "Exercise Timing and the Circadian Clock in Individuals With Type 2 Diabetes and Those at Risk", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Faculdade de Motricidade Humana", "sponsorKey": "faculdade de motricidade humana", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Type 2" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2024-01", "primaryCompletionDate": "2024-07", "lastUpdateDate": "2023-11-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06136013" }, { "nctId": "NCT02986659", "title": "Genomic Outcomes of Metformin", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Coronary Artery Disease", "Mild Cognitive Impairment", "Obesity, Abdominal", "Hypertension" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-08-03", "primaryCompletionDate": "2018-11-15", "lastUpdateDate": "2023-11-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02986659" }, { "nctId": "NCT04944992", "title": "A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001)", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Merck Sharp & Dohme", "sponsorKey": "merck sharp & dohme", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Nonalcoholic Fatty Liver Disease", "Nonalcoholic Steatohepatitis" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2021-08-04", "primaryCompletionDate": "2022-10-19", "lastUpdateDate": "2023-11-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04944992" }, { "nctId": "NCT05685394", "title": "DApagliflozin Cardiovascular Effects on Patients at End-stage REnal Disease", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "University of Campinas, Brazil", "sponsorKey": "university of campinas, brazil", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "End-stage Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-01-24", "primaryCompletionDate": "2024-11-01", "lastUpdateDate": "2023-11-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05685394" }, { "nctId": "NCT06079827", "title": "Impact of Therapeutic Plasma Exchange on RNA Biomarker Expression Levels in Alzheimer's Patients", "status": "UNKNOWN", "phases": [], "sponsor": "MaxWell Clinic", "sponsorKey": "maxwell clinic", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Alzheimer Disease" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2022-03-22", "primaryCompletionDate": "2024-09-01", "lastUpdateDate": "2023-10-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06079827" }, { "nctId": "NCT02354781", "title": "Clinical Intramuscular Gene Transfer of rAAV1.CMV.huFollistatin344 Trial to Patients With Duchenne Muscular Dystrophy", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Jerry R. Mendell", "sponsorKey": "jerry r. mendell", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Duchenne Muscular Dystrophy" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2015-01", "primaryCompletionDate": "2017-11", "lastUpdateDate": "2023-10-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02354781" }, { "nctId": "NCT05886673", "title": "Development of a Protective Cream Against Radiodermatitis Caused by Radiotherapy.", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Antonio J. Conde Moreno", "sponsorKey": "antonio j. conde moreno", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Radiodermatitis" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-03-29", "primaryCompletionDate": "2023-12", "lastUpdateDate": "2023-10-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05886673" }, { "nctId": "NCT02548364", "title": "Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz", "sponsorKey": "instituto de investigación sanitaria de la fundación jiménez díaz", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Myocardial Infarction" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-10", "primaryCompletionDate": "2023-05", "lastUpdateDate": "2023-10-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02548364" }, { "nctId": "NCT01519349", "title": "Follistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body Myositis", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Nationwide Children's Hospital", "sponsorKey": "nationwide children's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Becker Muscular Dystrophy", "Sporadic Inclusion Body Myositis" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2012-01", "primaryCompletionDate": "2017-10", "lastUpdateDate": "2023-10-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01519349" }, { "nctId": "NCT06036355", "title": "The Exploratory Study on the Biological Function of Dendritic Cells In Vivo Supported by Nicotinamide Mononucleotide (Vital NAD)", "status": "UNKNOWN", "phases": [ "EARLY_PHASE1" ], "sponsor": "Shanghai Cell Therapy Group", "sponsorKey": "shanghai cell therapy group", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Postoperative Prevention of Tumor" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-09-30", "primaryCompletionDate": "2024-04-30", "lastUpdateDate": "2023-09-13", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06036355" }, { "nctId": "NCT02310451", "title": "Study of Molecular Mechanisms Implicated in the Pathogenesis of Melanoma. Role of Exosomes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Centre Hospitalier Universitaire de Nice", "sponsorKey": "centre hospitalier universitaire de nice", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Metastatic Melanoma" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2014-12", "primaryCompletionDate": "2015-12", "lastUpdateDate": "2023-09-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02310451" }, { "nctId": "NCT02212262", "title": "Role of Osteocytes in Myeloma Bone Disease", "status": "COMPLETED", "phases": [], "sponsor": "Attaya Suvannasankha", "sponsorKey": "attaya suvannasankha", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Multiple Myeloma" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-10-07", "primaryCompletionDate": "2022-02-05", "lastUpdateDate": "2023-09-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02212262" }, { "nctId": "NCT05004220", "title": "Effects of Plasmapheresis on Aging Biomarkers", "status": "COMPLETED", "phases": [], "sponsor": "Charles University, Czech Republic", "sponsorKey": "charles university, czech republic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Plasmapheresis" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2021-04-06", "primaryCompletionDate": "2021-08-16", "lastUpdateDate": "2023-09-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05004220" }, { "nctId": "NCT06022744", "title": "An Exploratory Clinical Trial Evaluating LX109 Gene Therapy in Patients With nAMD", "status": "NOT_YET_RECRUITING", "phases": [ "NA" ], "sponsor": "Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine", "sponsorKey": "shanghai general hospital, shanghai jiao tong university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "To Evaluate the Safety and Tolerability of Intravitreal Injection of LX109 in Patients With nAMD" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-09-01", "primaryCompletionDate": "2025-09-30", "lastUpdateDate": "2023-09-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT06022744" }, { "nctId": "NCT02672826", "title": "Description of the Endothelial Phenotypes From the Subcutaneous Abdominal and Gluteo-femoral Adipose Tissues in Women", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University Hospital, Toulouse", "sponsorKey": "university hospital, toulouse", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2013-06-01", "primaryCompletionDate": "2016-04-24", "lastUpdateDate": "2023-08-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02672826" }, { "nctId": "NCT05984550", "title": "The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.", "status": "UNKNOWN", "phases": [ "EARLY_PHASE1" ], "sponsor": "Shanghai Cell Therapy Group", "sponsorKey": "shanghai cell therapy group", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Enhance Immune Function" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-08", "primaryCompletionDate": "2024-03", "lastUpdateDate": "2023-08-21", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05984550" }, { "nctId": "NCT02792413", "title": "Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease", "status": "TERMINATED", "phases": [ "PHASE4" ], "sponsor": "University Hospital, Montpellier", "sponsorKey": "university hospital, montpellier", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Female With Osteoporosis and Chronic Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-11-19", "primaryCompletionDate": "2020-12-10", "lastUpdateDate": "2023-08-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02792413" }, { "nctId": "NCT03748784", "title": "ADVM-022 Intravitreal Gene Therapy for Wet AMD", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Adverum Biotechnologies", "sponsorKey": "adverum biotechnologies", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "ADVM", "tickerCompany": "Adverum Biotechnologies Inc", "listingStatus": "ticker", "conditions": [ "Wet Age-related Macular Degeneration", "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2018-11-14", "primaryCompletionDate": "2022-06-22", "lastUpdateDate": "2023-08-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03748784" }, { "nctId": "NCT04771611", "title": "COVFIS-HOME: COVID-19 Pilot Study of Fisetin to Alleviate Dysfunction and Decrease Complications", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "James L. Kirkland, MD, PhD", "sponsorKey": "james l. kirkland, md, phd", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Covid19", "Coronavirus Infection" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2021-07-14", "primaryCompletionDate": "2022-09-27", "lastUpdateDate": "2023-08-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04771611" }, { "nctId": "NCT05276895", "title": "Effect of Natural Senolytic Agents & NLRP3 Inhibitors on Osteoarthritis", "status": "SUSPENDED", "phases": [ "NA" ], "sponsor": "Assiut University", "sponsorKey": "assiut university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteoarthritis" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-07-01", "primaryCompletionDate": "2024-09-01", "lastUpdateDate": "2023-07-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05276895" }, { "nctId": "NCT03821922", "title": "Fibroblast Growth Factor 23 and Hypertensive Disorder Complicating Pregnancy", "status": "UNKNOWN", "phases": [], "sponsor": "First Affiliated Hospital, Sun Yat-Sen University", "sponsorKey": "first affiliated hospital, sun yat-sen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension, Pregnancy-Induced" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-12-01", "primaryCompletionDate": "2023-12-30", "lastUpdateDate": "2023-07-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03821922" }, { "nctId": "NCT03432871", "title": "Nicotinamide Riboside and Mitochondrial Biogenesis", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Cambridge University Hospitals NHS Foundation Trust", "sponsorKey": "cambridge university hospitals nhs foundation trust", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mitochondrial Diseases", "Mitochondrial Myopathies", "Progressive External Ophthalmoplegia", "Progressive Ophthalmoplegia", "Progressive; Ophthalmoplegia, External", "Mitochondria DNA Deletion", "MELAS" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2017-12-08", "primaryCompletionDate": "2022-12-31", "lastUpdateDate": "2023-07-20", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03432871" }, { "nctId": "NCT04608448", "title": "Topical-RAPA Use in Inflammation Reversal and Re-setting the Epigenetic Clock", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Epigenetics", "Inflammatory Mediators" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2021-04-28", "primaryCompletionDate": "2022-04-15", "lastUpdateDate": "2023-07-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04608448" }, { "nctId": "NCT04181307", "title": "A Randomized Trial of a BE-EHR Module to Guide the Care of Older Adults With Diabetes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "NYU Langone Health", "sponsorKey": "nyu langone health", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2020-12-01", "primaryCompletionDate": "2022-07-01", "lastUpdateDate": "2023-07-19", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04181307" }, { "nctId": "NCT05946525", "title": "Ventilatory Variables in Subjects With Acute Respiratory Distress Syndrome Due to COVID-19", "status": "COMPLETED", "phases": [], "sponsor": "Hospital Donación Francisco Santojanni", "sponsorKey": "hospital donación francisco santojanni", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Respiratory Mechanics", "Respiration, Artificial", "Respiratory Distress Syndrome" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-02-10", "primaryCompletionDate": "2023-02-10", "lastUpdateDate": "2023-07-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05946525" }, { "nctId": "NCT03030196", "title": "Denosumab and Male Infertility: a RCT", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Martin Blomberg Jensen", "sponsorKey": "martin blomberg jensen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility, Male" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-01", "primaryCompletionDate": "2021-01", "lastUpdateDate": "2023-06-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03030196" }, { "nctId": "NCT05893849", "title": "Pharmacokinetics of Clinical Probes and Characteristics of Endogenous Biomarker in Chinese Older Adults", "status": "UNKNOWN", "phases": [], "sponsor": "Peking University Third Hospital", "sponsorKey": "peking university third hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2023-03-28", "primaryCompletionDate": "2024-03", "lastUpdateDate": "2023-06-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05893849" }, { "nctId": "NCT04118179", "title": "New Strategy to Predict Early Sepsis", "status": "UNKNOWN", "phases": [], "sponsor": "University of British Columbia", "sponsorKey": "university of british columbia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sepsis" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2018-08-01", "primaryCompletionDate": "2023-07-31", "lastUpdateDate": "2023-06-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04118179" }, { "nctId": "NCT05887310", "title": "In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent Cells", "status": "UNKNOWN", "phases": [], "sponsor": "University of Milano Bicocca", "sponsorKey": "university of milano bicocca", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Depressive Disorder, Treatment-Resistant" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2022-08-05", "primaryCompletionDate": "2024-08-05", "lastUpdateDate": "2023-06-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05887310" }, { "nctId": "NCT03066258", "title": "Safety and Tolerability of RGX-314 (Investigational Product) Gene Therapy for Neovascular AMD Trial", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "REGENXBIO", "sponsorKey": "regenxbio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "RGNX", "tickerCompany": "REGENXBIO Inc", "listingStatus": "ticker", "conditions": [ "Neovascular Age-related Macular Degeneration", "Wet Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2017-03-29", "primaryCompletionDate": "2019-11-24", "lastUpdateDate": "2023-05-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03066258" }, { "nctId": "NCT03973203", "title": "Niacin Supplementation in Healthy Controls and Mitochondrial Myopathy Patients", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Helsinki", "sponsorKey": "university of helsinki", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mitochondrial Myopathies" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2014-06-01", "primaryCompletionDate": "2017-12-31", "lastUpdateDate": "2023-05-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03973203" }, { "nctId": "NCT03797196", "title": "RCT Comparing Immunosuppressive Regimens in Elderly Renal Transplant Recipients", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE4" ], "sponsor": "University Medical Center Groningen", "sponsorKey": "university medical center groningen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Transplant Recipients", "Elderly Patients", "Immunosuppression" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2019-07-29", "primaryCompletionDate": "2025-06", "lastUpdateDate": "2023-05-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03797196" }, { "nctId": "NCT05482672", "title": "GetHealthy-OA: A Program to Improve Pain and Function for Patients With Knee Osteoarthritis, Obesity, and Depression", "status": "WITHDRAWN", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Cale Andrew Jacobs, PhD", "sponsorKey": "cale andrew jacobs, phd", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Knee Osteoarthritis", "Obese", "Depression" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-04", "primaryCompletionDate": "2023-04", "lastUpdateDate": "2023-05-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05482672" }, { "nctId": "NCT05611424", "title": "Gene Therapy for Wet AMD", "status": "NOT_YET_RECRUITING", "phases": [ "PHASE1" ], "sponsor": "Frontera Therapeutics", "sponsorKey": "frontera therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Neovascular Age-related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2023-05-01", "primaryCompletionDate": "2024-11-30", "lastUpdateDate": "2023-04-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05611424" }, { "nctId": "NCT05593939", "title": "Slow Age: Interventions to Slow Aging in Humans", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-05-01", "primaryCompletionDate": "2022-12-21", "lastUpdateDate": "2023-04-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05593939" }, { "nctId": "NCT03642990", "title": "NR in Chemo-induced Peripheral Neuropathy", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Donna Hammond, PhD", "sponsorKey": "donna hammond, phd", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chemotherapy-induced Peripheral Neuropathy", "Breast Cancer Metastatic", "Platinum-resistant Recurrent Ovarian Cancer", "Head and Neck Cancer Stage IV", "Endometrial Cancer Stage IV" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-11-08", "primaryCompletionDate": "2021-08-18", "lastUpdateDate": "2023-04-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03642990" }, { "nctId": "NCT05571709", "title": "The Effect of Exercise on Myokine Production in Aging Persons", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Hasselt University", "sponsorKey": "hasselt university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Exercise" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2022-09-15", "primaryCompletionDate": "2023-10-15", "lastUpdateDate": "2023-03-31", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05571709" }, { "nctId": "NCT04910061", "title": "Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults.", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Seneque", "sponsorKey": "seneque", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Volunteers" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-08-05", "primaryCompletionDate": "2022-09-01", "lastUpdateDate": "2023-03-30", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04910061" }, { "nctId": "NCT03674957", "title": "The Manitoba Personalized Lifestyle Research (TMPLR) Study", "status": "TERMINATED", "phases": [], "sponsor": "University of Manitoba", "sponsorKey": "university of manitoba", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes", "Cardiovascular Diseases", "Chronic Kidney Diseases" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2016-03", "primaryCompletionDate": "2018-12", "lastUpdateDate": "2023-03-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03674957" }, { "nctId": "NCT05732051", "title": "Nicotinamide Riboside and Prevention of Cancer Therapy Related Cardiac Dysfunction in Breast Cancer Patients", "status": "RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University Hospital, Akershus", "sponsorKey": "university hospital, akershus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Breast Cancer", "Metastatic Breast Cancer", "Cancer Therapy-Related Cardiac Dysfunction", "Cardiotoxicity", "Heart Failure" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-03-16", "primaryCompletionDate": "2025-08-01", "lastUpdateDate": "2023-03-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05732051" }, { "nctId": "NCT02659306", "title": "Metformin Immunotherapy in HIV Infection", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "McGill University Health Centre/Research Institute of the McGill University Health Centre", "sponsorKey": "mcgill university health centre/research institute of the mcgill university health centre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "HIV Infection" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-09", "primaryCompletionDate": "2018-08-14", "lastUpdateDate": "2023-03-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02659306" }, { "nctId": "NCT05757271", "title": "Serum Levels of Klotho as a Possible Biomarker of Peripheral Artery Disease", "status": "UNKNOWN", "phases": [], "sponsor": "Fondazione Policlinico Universitario Agostino Gemelli IRCCS", "sponsorKey": "fondazione policlinico universitario agostino gemelli irccs", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Peripheral Arterial Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-10-23", "primaryCompletionDate": "2023-10-31", "lastUpdateDate": "2023-03-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05757271" }, { "nctId": "NCT04063124", "title": "Senolytic Therapy to Modulate Progression of Alzheimer's Disease", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2020-02-14", "primaryCompletionDate": "2021-12-10", "lastUpdateDate": "2023-03-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04063124" }, { "nctId": "NCT03499327", "title": "Human Intervention Study to Increase 25-hydroxyvitamin D Levels", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Jena", "sponsorKey": "university of jena", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vitamin D3 Deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-03-05", "primaryCompletionDate": "2018-04-30", "lastUpdateDate": "2023-02-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03499327" }, { "nctId": "NCT05256004", "title": "Cardiac Biomarkers and Iron Status in Hemodialysis Patients", "status": "COMPLETED", "phases": [], "sponsor": "Tungs' Taichung Metroharbour Hospital", "sponsorKey": "tungs' taichung metroharbour hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure", "Iron-deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-06-01", "primaryCompletionDate": "2022-12-31", "lastUpdateDate": "2023-02-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05256004" }, { "nctId": "NCT04050358", "title": "Effect of Basis™ and High Intensity Interval Training (HIIT) on Muscle Metabolism and Exercise Performance", "status": "WITHDRAWN", "phases": [ "PHASE1" ], "sponsor": "Elysium Health", "sponsorKey": "elysium health", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2023-02", "primaryCompletionDate": "2023-04", "lastUpdateDate": "2023-02-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04050358" }, { "nctId": "NCT04907110", "title": "NR Supplementation and Exercise", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Maastricht University Medical Center", "sponsorKey": "maastricht university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight and Obesity", "Aging", "Type 2 Diabetes" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-08-10", "primaryCompletionDate": "2022-12-02", "lastUpdateDate": "2023-02-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04907110" }, { "nctId": "NCT05293535", "title": "Klotho _ LRP-6 _ Gastric Adenocarcinoma", "status": "UNKNOWN", "phases": [], "sponsor": "Assiut University", "sponsorKey": "assiut university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Gastric Adenocarcinoma", "Klotho", "LRP-6" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2023-04-01", "primaryCompletionDate": "2024-04-01", "lastUpdateDate": "2023-01-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05293535" }, { "nctId": "NCT04862338", "title": "Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Seneque", "sponsorKey": "seneque", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Healthy Volunteers" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-04-26", "primaryCompletionDate": "2021-09-08", "lastUpdateDate": "2023-01-26", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04862338" }, { "nctId": "NCT03772964", "title": "Effects of Metformin in a Non-Diabetic Patient Population", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Brian Zuckerbraun", "sponsorKey": "brian zuckerbraun", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Inflammatory Response" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-01-22", "primaryCompletionDate": "2020-03-31", "lastUpdateDate": "2023-01-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03772964" }, { "nctId": "NCT03579693", "title": "Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "University of Washington", "sponsorKey": "university of washington", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease", "Sarcopenia", "Frailty" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-11-14", "primaryCompletionDate": "2021-04-26", "lastUpdateDate": "2023-01-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03579693" }, { "nctId": "NCT04856683", "title": "PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin", "status": "UNKNOWN", "phases": [], "sponsor": "University of Roma La Sapienza", "sponsorKey": "university of roma la sapienza", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty" ], "topics": [ "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "metformin", "glp1_aging" ], "startDate": "2020-08-10", "primaryCompletionDate": "2023-08", "lastUpdateDate": "2022-11-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04856683" }, { "nctId": "NCT03451006", "title": "Effect of Metformin on Frailty in 12 Subjects", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Inflammation", "Frailty" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2018-05-24", "primaryCompletionDate": "2021-12-16", "lastUpdateDate": "2022-11-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03451006" }, { "nctId": "NCT03423342", "title": "Nicotinamide Riboside in Systolic Heart Failure", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Washington", "sponsorKey": "university of washington", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure, Systolic" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-05-19", "primaryCompletionDate": "2019-04-11", "lastUpdateDate": "2022-11-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03423342" }, { "nctId": "NCT02708368", "title": "SOP's for CKD-MBD-Biomarkers", "status": "COMPLETED", "phases": [], "sponsor": "RWTH Aachen University", "sponsorKey": "rwth aachen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-06-01", "primaryCompletionDate": "2016-11-01", "lastUpdateDate": "2022-10-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02708368" }, { "nctId": "NCT05485610", "title": "Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Peking University Third Hospital", "sponsorKey": "peking university third hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diminished Ovarian Reserve", "Premature Ovarian Insufficiency" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-07-01", "primaryCompletionDate": "2024-12-31", "lastUpdateDate": "2022-10-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05485610" }, { "nctId": "NCT04407390", "title": "Effects of Nicotinamide Riboside on the Clinical Outcome of Covid-19 in the Elderly", "status": "WITHDRAWN", "phases": [ "PHASE2" ], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "COVID" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-06-01", "primaryCompletionDate": "2021-05-01", "lastUpdateDate": "2022-09-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04407390" }, { "nctId": "NCT05503147", "title": "Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Ove Andersen", "sponsorKey": "ove andersen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Malnutrition", "Anorexia", "Cannabis", "Aging", "Emergency Service, Hospital", "Renal Function", "Pharmacokinetics" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2022-03-24", "primaryCompletionDate": "2023-08-01", "lastUpdateDate": "2022-09-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05503147" }, { "nctId": "NCT04606420", "title": "Can Lifestyle Changes Reverse Early-Stage Alzheimer's Disease", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Preventive Medicine Research Institute", "sponsorKey": "preventive medicine research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2018-09-08", "primaryCompletionDate": "2023-09-30", "lastUpdateDate": "2022-09-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04606420" }, { "nctId": "NCT04870866", "title": "NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "University Hospital, Akershus", "sponsorKey": "university hospital, akershus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ataxia Telangiectasia" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-06-05", "primaryCompletionDate": "2024-09-03", "lastUpdateDate": "2022-08-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04870866" }, { "nctId": "NCT00628199", "title": "Study to Create Potential Cell-Based Therapies to Treat Human Disease and Disability", "status": "ENROLLING_BY_INVITATION", "phases": [], "sponsor": "Stanford University", "sponsorKey": "stanford university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Metabolic Diseases", "Infertility" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2007-09", "primaryCompletionDate": "2030-01", "lastUpdateDate": "2022-08-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00628199" }, { "nctId": "NCT05344404", "title": "NR-SAFE: Safety of High-dose Nicotinamide Riboside (NR) in Parkinson's Disease", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2022-04-29", "primaryCompletionDate": "2022-07-01", "lastUpdateDate": "2022-08-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05344404" }, { "nctId": "NCT02656017", "title": "Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Kyongtae Ty Bae, M.D., Ph.D", "sponsorKey": "kyongtae ty bae, m.d., ph.d", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Polycystic Kidney, Autosomal Dominant" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-06-27", "primaryCompletionDate": "2020-12-07", "lastUpdateDate": "2022-08-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02656017" }, { "nctId": "NCT04044131", "title": "Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Istanbul Medipol University Hospital", "sponsorKey": "istanbul medipol university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease", "Parkinson Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-12-02", "primaryCompletionDate": "2021-03-15", "lastUpdateDate": "2022-08-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04044131" }, { "nctId": "NCT03489993", "title": "FGF23 and Angiotensin-(1-7) in Hypophosphatemia (GAP)", "status": "COMPLETED", "phases": [], "sponsor": "Wake Forest University Health Sciences", "sponsorKey": "wake forest university health sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypophosphatemia", "X-linked Hypophosphatemia", "Renin-angiotensin System", "Left Ventricular Hypertrophy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-12-06", "primaryCompletionDate": "2020-12-23", "lastUpdateDate": "2022-08-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03489993" }, { "nctId": "NCT02721537", "title": "Use of 31P MRS to Assess Brain NAD+ in Healthy Current and Former Collegiate Athletes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Concussion, Mild" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-09", "primaryCompletionDate": "2022-08", "lastUpdateDate": "2022-08-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02721537" }, { "nctId": "NCT04770064", "title": "Targeting Senescence to Reduce Osteoarthritis Pain and cartilagE Breakdown (ROPE)", "status": "WITHDRAWN", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Austin V Stone", "sponsorKey": "austin v stone", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Osteoarthritis, Knee" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2023-06", "primaryCompletionDate": "2024-05-31", "lastUpdateDate": "2022-07-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04770064" }, { "nctId": "NCT03962114", "title": "Effects of Vitamin B3 in Patients With Ataxia Telangiectasia", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Radboud University Medical Center", "sponsorKey": "radboud university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Ataxia Telangiectasia", "ATM Gene Mutation" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-03-18", "primaryCompletionDate": "2019-12-01", "lastUpdateDate": "2022-07-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03962114" }, { "nctId": "NCT02672293", "title": "Determining Oral Phosphate Tolerance Across the Spectrum of Glomerular Filtration Rate", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Dr. Rachel Holden", "sponsorKey": "dr. rachel holden", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2013-01", "primaryCompletionDate": "2018-04-18", "lastUpdateDate": "2022-07-05", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02672293" }, { "nctId": "NCT05230901", "title": "Effect of Antifibrotic Therapy on Regression of Myocardial Fibrosis After Transcatheter Aortic Valve Implantation (TAVI) in Aortic Stenosis Patients With High Fibrotic Burden", "status": "UNKNOWN", "phases": [ "PHASE3" ], "sponsor": "University Medical Center Goettingen", "sponsorKey": "university medical center goettingen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aortic Stenosis, Severe" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2022-02-23", "primaryCompletionDate": "2025-06", "lastUpdateDate": "2022-06-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05230901" }, { "nctId": "NCT04994561", "title": "VIAging Deceleration Trial Using Metformin, Dasatinib, Rapamycin and Nutritional Supplements", "status": "WITHDRAWN", "phases": [ "PHASE1" ], "sponsor": "Vitality in Aging Research Group", "sponsorKey": "vitality in aging research group", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN", "Rapamycin", "Metformin / TAME" ], "topicKeys": [ "nad_nmn", "rapamycin", "metformin" ], "startDate": "2022-06", "primaryCompletionDate": "2023-12", "lastUpdateDate": "2022-06-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04994561" }, { "nctId": "NCT04962841", "title": "Nutraceuticals and Drug Treatment in Frail Older Adults", "status": "UNKNOWN", "phases": [], "sponsor": "University of Campania Luigi Vanvitelli", "sponsorKey": "university of campania luigi vanvitelli", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frailty" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2020-04-01", "primaryCompletionDate": "2021-07-22", "lastUpdateDate": "2022-05-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04962841" }, { "nctId": "NCT03682458", "title": "Study of Neurodegenerative Diseases Induced Stem Cells in Patients and Healthy Family Controls.", "status": "UNKNOWN", "phases": [], "sponsor": "Neuromed IRCCS", "sponsorKey": "neuromed irccs", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Neurodegenerative Diseases" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2019-12-01", "primaryCompletionDate": "2022-12-01", "lastUpdateDate": "2022-04-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03682458" }, { "nctId": "NCT05054894", "title": "Plasmapheresis for Treatment of Age-Related Frailty", "status": "UNKNOWN", "phases": [ "EARLY_PHASE1" ], "sponsor": "Neurological Associates of West Los Angeles", "sponsorKey": "neurological associates of west los angeles", "sponsorType": "other", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Frailty" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2021-03-19", "primaryCompletionDate": "2025-04", "lastUpdateDate": "2022-04-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05054894" }, { "nctId": "NCT04717219", "title": "Myeloid Cells in Aortic Valve Stenosis", "status": "UNKNOWN", "phases": [], "sponsor": "Radboud University Medical Center", "sponsorKey": "radboud university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aortic Valve Disease", "Aortic Valve Stenosis" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2020-11-19", "primaryCompletionDate": "2022-12-31", "lastUpdateDate": "2022-04-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04717219" }, { "nctId": "NCT04981652", "title": "The Effect of Whole Milk to Improve Muscle Health in Older Women", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "McMaster University", "sponsorKey": "mcmaster university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Dairy Products", "Muscle Protein Synthesis", "Aging", "Physical Activity" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2018-06-01", "primaryCompletionDate": "2020-03-01", "lastUpdateDate": "2022-04-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04981652" }, { "nctId": "NCT04735562", "title": "Thrombospondin-4 Levels and Peripheral Arterial Disease in Hemodialysis Patients", "status": "COMPLETED", "phases": [], "sponsor": "Tungs' Taichung Metroharbour Hospital", "sponsorKey": "tungs' taichung metroharbour hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Peripheral Arterial Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-04-01", "primaryCompletionDate": "2021-12-31", "lastUpdateDate": "2022-02-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04735562" }, { "nctId": "NCT03397238", "title": "Myeloid Cell Reprogramming in Thyroid Carcinoma", "status": "COMPLETED", "phases": [], "sponsor": "Radboud University Medical Center", "sponsorKey": "radboud university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Thyroid Cancer" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2018-03-06", "primaryCompletionDate": "2019-11-26", "lastUpdateDate": "2022-02-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03397238" }, { "nctId": "NCT04903210", "title": "Nicotinamide Mononucleotide in Hypertensive Patients", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "First Affiliated Hospital, Sun Yat-Sen University", "sponsorKey": "first affiliated hospital, sun yat-sen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypertension" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-06-01", "primaryCompletionDate": "2022-06-20", "lastUpdateDate": "2022-02-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04903210" }, { "nctId": "NCT05214872", "title": "The Impact of Selected Factors on the Cardiovascular System in Chronic Kidney Disease", "status": "COMPLETED", "phases": [], "sponsor": "Poznan University of Medical Sciences", "sponsorKey": "poznan university of medical sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Atherosclerosis of Artery", "Inflammation", "Chronic Kidney Diseases", "Dialysis; Complications", "Cardiovascular Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-03-25", "primaryCompletionDate": "2020-09-10", "lastUpdateDate": "2022-01-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05214872" }, { "nctId": "NCT04939870", "title": "Assessment of Protein Modification in Chronic Kidney Disease - Selected Clinical and Biochemical Aspects", "status": "COMPLETED", "phases": [], "sponsor": "Poznan University of Medical Sciences", "sponsorKey": "poznan university of medical sciences", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Diseases", "Cardiovascular Diseases", "Dialysis; Complications" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-01-01", "primaryCompletionDate": "2018-12-31", "lastUpdateDate": "2021-12-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04939870" }, { "nctId": "NCT04841499", "title": "Effects of a Seven-day BASIS™ Supplementation on Menopausal Syndromes and Measurements of the Urinary Vitamin B3 and Estradiol Levels in Pre-, Peri- and Post-menopause", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of South Alabama", "sponsorKey": "university of south alabama", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Menopause" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-04-05", "primaryCompletionDate": "2021-07-15", "lastUpdateDate": "2021-11-18", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04841499" }, { "nctId": "NCT05124756", "title": "Effects of Bioelectric Stimulation in Patients With Non-Dialysis Dependent Chronic Kidney Disease", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Federal University of Health Science of Porto Alegre", "sponsorKey": "federal university of health science of porto alegre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Insufficiency, Chronic", "Electric Stimulation" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2021-11-25", "primaryCompletionDate": "2022-06-25", "lastUpdateDate": "2021-11-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05124756" }, { "nctId": "NCT05113914", "title": "The Age-related Changes of Energy Metabolism in Physically Fit Adult Males", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Poznan University of Physical Education", "sponsorKey": "poznan university of physical education", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2011-01-01", "primaryCompletionDate": "2019-11-30", "lastUpdateDate": "2021-11-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT05113914" }, { "nctId": "NCT04736251", "title": "Mechanistic Basis of Ablative Carbon Dioxide Laser in Treating Hypertrophic Scars", "status": "UNKNOWN", "phases": [], "sponsor": "Naiem Moiemen", "sponsorKey": "naiem moiemen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Burn Scar", "Scar" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2019-12-09", "primaryCompletionDate": "2023-08-31", "lastUpdateDate": "2021-11-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04736251" }, { "nctId": "NCT04823260", "title": "To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Abinopharm", "sponsorKey": "abinopharm", "sponsorType": "industry", "sponsorClass": "NETWORK", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2021-05-25", "primaryCompletionDate": "2021-09-09", "lastUpdateDate": "2021-10-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04823260" }, { "nctId": "NCT02065687", "title": "Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer", "status": "UNKNOWN", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Gynecologic Oncology Group", "sponsorKey": "gynecologic oncology group", "sponsorType": "academic", "sponsorClass": "NETWORK", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Endometrial Adenocarcinoma", "Endometrial Clear Cell Adenocarcinoma", "Endometrial Serous Adenocarcinoma", "Endometrial Undifferentiated Carcinoma", "Recurrent Uterine Corpus Carcinoma", "Stage III Uterine Corpus Cancer AJCC v7", "Stage IIIA Uterine Corpus Cancer AJCC v7", "Stage IIIB Uterine Corpus Cancer AJCC v7", "Stage IIIC Uterine Corpus Cancer AJCC v7", "Stage IV Uterine Corpus Cancer AJCC v7", "Stage IVA Uterine Corpus Cancer AJCC v7", "Stage IVB Uterine Corpus Cancer AJCC v7" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2014-03-17", "primaryCompletionDate": "2019-04-17", "lastUpdateDate": "2021-09-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02065687" }, { "nctId": "NCT01808690", "title": "EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "University of Colorado, Denver", "sponsorKey": "university of colorado, denver", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 1 Diabetes" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2013-03", "primaryCompletionDate": "2016-12-02", "lastUpdateDate": "2021-09-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01808690" }, { "nctId": "NCT04106310", "title": "Theranova vs High-flux HD Comparison", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "The University of Hong Kong", "sponsorKey": "the university of hong kong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "End Stage Renal Failure on Dialysis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-11-01", "primaryCompletionDate": "2021-06-30", "lastUpdateDate": "2021-09-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04106310" }, { "nctId": "NCT02942888", "title": "The Effects of Nicotinamide Adenine Dinucleotide (NAD) on Brain Function and Cognition", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment", "NAD" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2017-11-30", "primaryCompletionDate": "2019-08-31", "lastUpdateDate": "2021-09-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02942888" }, { "nctId": "NCT03151239", "title": "Effect of \"Nicotinamide Mononucleotide\" (NMN) on Cardiometabolic Function", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Washington University School of Medicine", "sponsorKey": "washington university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Glucose Metabolism Disorders" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2017-07-01", "primaryCompletionDate": "2019-05-30", "lastUpdateDate": "2021-07-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03151239" }, { "nctId": "NCT04961931", "title": "Effect of Empagliflozin on Urinary Excretion of Adenosine and Osteocyte Function in Patients With Chronic Kidney Disease", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Medical University of Lodz", "sponsorKey": "medical university of lodz", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease stage3" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-01-01", "primaryCompletionDate": "2021-08-31", "lastUpdateDate": "2021-07-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04961931" }, { "nctId": "NCT01445548", "title": "Sirolimus for Advanced Age-Related Macular Degeneration", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "National Eye Institute (NEI)", "sponsorKey": "national eye institute (nei)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Macular Degeneration", "Geographic Atrophy" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2011-09", "primaryCompletionDate": "2013-04", "lastUpdateDate": "2021-07-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01445548" }, { "nctId": "NCT03652987", "title": "Endocrine and Menstrual Disturbances in Women With Polycystic Ovary Syndrome (PCOS)", "status": "SUSPENDED", "phases": [], "sponsor": "St George's, University of London", "sponsorKey": "st george's, university of london", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Polycystic Ovary Syndrome", "Insulin Resistance", "Vitamin D Deficiency", "Obesity" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2018-09-05", "primaryCompletionDate": "2022-12", "lastUpdateDate": "2021-05-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03652987" }, { "nctId": "NCT02432287", "title": "Metformin in Longevity Study (MILES).", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Albert Einstein College of Medicine", "sponsorKey": "albert einstein college of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2014-10", "primaryCompletionDate": "2015-09", "lastUpdateDate": "2021-05-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02432287" }, { "nctId": "NCT04897113", "title": "Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "National Medical Research Center for Rehabilitation and Balneology", "sponsorKey": "national medical research center for rehabilitation and balneology", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypercholesterolemia", "Hyperbilirubinemia", "Hyper IgE Syndrome", "Hyper Beta Lipoproteinemia", "Hyper Eosinophilic Syndrome", "Hyper-LDL-cholesterolemia", "Gout", "Diabetes", "Nervous System Diseases", "Neuromuscular Diseases", "Cardiovascular Diseases", "Urologic Diseases" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2021-05-12", "primaryCompletionDate": "2022-10-30", "lastUpdateDate": "2021-05-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04897113" }, { "nctId": "NCT04358471", "title": "Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)", "status": "WITHDRAWN", "phases": [ "PHASE2" ], "sponsor": "Hemera Biosciences", "sponsorKey": "hemera biosciences", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Dry Age-related Macular Degeneration", "Geographic Atrophy", "Gene Therapy", "Intravitreal Injection" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2021-07-31", "primaryCompletionDate": "2023-07-01", "lastUpdateDate": "2021-05-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04358471" }, { "nctId": "NCT04685096", "title": "Anti-ageing Efficacy of a Cosmetic Formulation Containing NMN (2%) Versus Placebo", "status": "COMPLETED", "phases": [], "sponsor": "Seneque", "sponsorKey": "seneque", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Wrinkle", "Fatigue", "Puffiness Around the Eyes" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-12-12", "primaryCompletionDate": "2021-03-12", "lastUpdateDate": "2021-04-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04685096" }, { "nctId": "NCT03928769", "title": "PROGENitors, TELomeres and ARTerial Aging", "status": "SUSPENDED", "phases": [], "sponsor": "Central Hospital, Nancy, France", "sponsorKey": "central hospital, nancy, france", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Atherosclerosis of Artery" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2019-05-08", "primaryCompletionDate": "2021-04-20", "lastUpdateDate": "2021-04-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03928769" }, { "nctId": "NCT04228640", "title": "Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "EffePharm", "sponsorKey": "effepharm", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2020-12-15", "primaryCompletionDate": "2021-02-27", "lastUpdateDate": "2021-04-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04228640" }, { "nctId": "NCT02237534", "title": "Lanthanum Versus Calcium Carbonate for Vascular Abnormalities in Patients With CKD and Hyperphosphatemia", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "Osaka University", "sponsorKey": "osaka university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Insufficiency, Chronic", "Hyperphosphatemia", "Bone Diseases, Metabolic" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-09", "primaryCompletionDate": "2023-03-31", "lastUpdateDate": "2021-02-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02237534" }, { "nctId": "NCT03457870", "title": "Intermittent Energy Restriction and Chewing on Neural Stem Cell Ageing and Adult Hippocampal Neurogenesis Associated Cognition", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "King's College London", "sponsorKey": "king's college london", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Cognitive Decline" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-04-18", "primaryCompletionDate": "2020-03-23", "lastUpdateDate": "2021-02-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03457870" }, { "nctId": "NCT04383197", "title": "Exercise and GLP-1 RA on Insulin Secretion", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2019-12-10", "primaryCompletionDate": "2021-08", "lastUpdateDate": "2021-02-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04383197" }, { "nctId": "NCT04361357", "title": "The Effects of Enteral Whey Protein Supplement on Serum Albumin Level in Acute Critically Ill Neurological Patients", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Xuanwu Hospital, Beijing", "sponsorKey": "xuanwu hospital, beijing", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Nutrition Disorders", "Neurologic Disorder" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2020-01-05", "primaryCompletionDate": "2022-12-31", "lastUpdateDate": "2021-02-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04361357" }, { "nctId": "NCT04584710", "title": "A Phase 2 Study of RTB101 as COVID-19 Post-Exposure Prophylaxis in Older Adults", "status": "ACTIVE_NOT_RECRUITING", "phases": [ "PHASE2" ], "sponsor": "Restorbio", "sponsorKey": "restorbio", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Covid19" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2020-10-13", "primaryCompletionDate": "2021-02", "lastUpdateDate": "2021-02-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04584710" }, { "nctId": "NCT04538521", "title": "NiaMIT Continuation With Early-stage Mitochondrial Myopathy Patients", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Helsinki", "sponsorKey": "university of helsinki", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mitochondrial Myopathies" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-02-11", "primaryCompletionDate": "2020-09-18", "lastUpdateDate": "2021-01-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04538521" }, { "nctId": "NCT03224234", "title": "A Randomized Study to Evaluate the Efficacy of Insulclock® in Patients With Uncontrolled Type 2 Diabetes", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Emory University", "sponsorKey": "emory university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2017-11-29", "primaryCompletionDate": "2019-09-18", "lastUpdateDate": "2021-01-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03224234" }, { "nctId": "NCT04630132", "title": "Renal Ageing-sarcopenia Network", "status": "UNKNOWN", "phases": [], "sponsor": "IRCCS San Raffaele", "sponsorKey": "irccs san raffaele", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Frailty", "Hypertension", "CKD" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-03-25", "primaryCompletionDate": "2021-03-31", "lastUpdateDate": "2020-12-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04630132" }, { "nctId": "NCT03789175", "title": "Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cancer", "Skin Fibroblasts", "Muscle Weakness" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-03-25", "primaryCompletionDate": "2019-11-01", "lastUpdateDate": "2020-12-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03789175" }, { "nctId": "NCT02905539", "title": "A Study Comparing the Iron Substitution With the Medicinal Products Ferinject or Monofer", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Universität des Saarlandes", "sponsorKey": "universität des saarlandes", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Anemia, Iron-Deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-07", "primaryCompletionDate": "2020-06", "lastUpdateDate": "2020-11-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02905539" }, { "nctId": "NCT03754842", "title": "Effect of Nicotinamide Riboside and Pterostilbene Supplementation on Muscle Regeneration in Elderly Humans", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Aarhus", "sponsorKey": "university of aarhus", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Muscle Injury" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-02-12", "primaryCompletionDate": "2020-09-01", "lastUpdateDate": "2020-11-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03754842" }, { "nctId": "NCT04608422", "title": "Bioeletric Stimulation in Patients With Chronic Kidney Failure", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Federal University of Health Science of Porto Alegre", "sponsorKey": "federal university of health science of porto alegre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease Stage 5", "Electric Stimulation" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2020-11-01", "primaryCompletionDate": "2021-02-28", "lastUpdateDate": "2020-11-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04608422" }, { "nctId": "NCT03565328", "title": "The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-09-27", "primaryCompletionDate": "2019-11-18", "lastUpdateDate": "2020-10-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03565328" }, { "nctId": "NCT03596554", "title": "X-linked Hypophosphatemia and FGF21", "status": "COMPLETED", "phases": [], "sponsor": "Hospices Civils de Lyon", "sponsorKey": "hospices civils de lyon", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "X-linked Hypophosphatemia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-01-11", "primaryCompletionDate": "2020-02-27", "lastUpdateDate": "2020-10-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03596554" }, { "nctId": "NCT00620191", "title": "Metformin in Amnestic Mild Cognitive Impairment", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Columbia University", "sponsorKey": "columbia university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Mild Cognitive Impairment" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2008-06-01", "primaryCompletionDate": "2012-02", "lastUpdateDate": "2020-10-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00620191" }, { "nctId": "NCT03501433", "title": "Effects of Nicotinamide Riboside on Metabolism and Vascular Function", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Iowa State University", "sponsorKey": "iowa state university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Lipemia" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-02-01", "primaryCompletionDate": "2019-12-01", "lastUpdateDate": "2020-09-25", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03501433" }, { "nctId": "NCT01573949", "title": "A Pilot Study: Metformin Therapy in Heart Failure Patients With Early Diabetes or at High Risk of Developing Diabetes (Pre-Diabetes)", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of California, Los Angeles", "sponsorKey": "university of california, los angeles", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes", "Heart Failure" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2011-12", "primaryCompletionDate": "2012-12", "lastUpdateDate": "2020-09-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01573949" }, { "nctId": "NCT01122316", "title": "Management of Diabetes With Metformin In Patients With Chronic Heart Failure", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of California, Los Angeles", "sponsorKey": "university of california, los angeles", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure", "Diabetes" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2009-09", "primaryCompletionDate": "2012-01", "lastUpdateDate": "2020-09-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01122316" }, { "nctId": "NCT03996746", "title": "Evaluation of Serum Klotho as a Predictor of Progression of Cardiovascular Calcification in Chronic Kidney Disease", "status": "UNKNOWN", "phases": [], "sponsor": "Xinhua Hospital, Shanghai Jiao Tong University School of Medicine", "sponsorKey": "xinhua hospital, shanghai jiao tong university school of medicine", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-06-25", "primaryCompletionDate": "2021-09-30", "lastUpdateDate": "2020-08-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03996746" }, { "nctId": "NCT04478916", "title": "Impact of the Comprehensive Geriatric Assessment on the Quality of Life OF Elderly Patients", "status": "UNKNOWN", "phases": [], "sponsor": "Lorenza Scotti", "sponsorKey": "lorenza scotti", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hematologic Malignancies", "Solid Tumor", "Elderly Patients" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2019-12-18", "primaryCompletionDate": "2021-09", "lastUpdateDate": "2020-07-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04478916" }, { "nctId": "NCT03996538", "title": "Vaccination Efficacy With Metformin in Older Adults", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "UConn Health", "sponsorKey": "uconn health", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Age-Related Immunodeficiency", "Vaccine Response Impaired" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2019-06-05", "primaryCompletionDate": "2020-02-04", "lastUpdateDate": "2020-07-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03996538" }, { "nctId": "NCT00766649", "title": "Pilot Study of the Evaluation of Subconjunctival Sirolimus in the Treatment of Bilateral GA Associated With AMD", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "National Eye Institute (NEI)", "sponsorKey": "national eye institute (nei)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2008-10", "primaryCompletionDate": "2012-04", "lastUpdateDate": "2020-07-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00766649" }, { "nctId": "NCT01865981", "title": "Investigating Hereditary Cardiac Disease by Reprogramming Skin Cells to Heart Muscle", "status": "COMPLETED", "phases": [], "sponsor": "University of Dundee", "sponsorKey": "university of dundee", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Eletrophysiology of iPS-derived Cardiomyocytes" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2013-06", "primaryCompletionDate": "2017-06-01", "lastUpdateDate": "2020-07-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01865981" }, { "nctId": "NCT03912623", "title": "Evaluation of the Benefit at 6 Months of a 3 Weeks Spa Treatment in the Type 2 Diabetic Patient.", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Association Francaise pour la Recherche Thermale", "sponsorKey": "association francaise pour la recherche thermale", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus", "Physical Activity", "Dietetic Rules", "Therapeutic Education" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2019-09-13", "primaryCompletionDate": "2022-03-01", "lastUpdateDate": "2020-07-01", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03912623" }, { "nctId": "NCT04439682", "title": "The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Gazi University", "sponsorKey": "gazi university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Rheumatoid Arthritis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2020-07-17", "primaryCompletionDate": "2020-09-17", "lastUpdateDate": "2020-06-19", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04439682" }, { "nctId": "NCT03182699", "title": "Effect of Etelcalcetide on Cardiac Hypertrophy in Hemodialysis Patients", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Rainer Oberbauer", "sponsorKey": "rainer oberbauer", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Secondary Hyperparathyroidism", "Chronic Kidney Disease Requiring Chronic Dialysis", "Left Ventricular Hypertrophy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-10-01", "primaryCompletionDate": "2019-12-20", "lastUpdateDate": "2020-06-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03182699" }, { "nctId": "NCT03771924", "title": "Postprandial Response of Individuals to Dietary Inorganic Phosphate", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Martin-Luther-Universität Halle-Wittenberg", "sponsorKey": "martin-luther-universität halle-wittenberg", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cardiovascular Risk Factor" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-08-16", "primaryCompletionDate": "2018-11-25", "lastUpdateDate": "2020-05-19", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03771924" }, { "nctId": "NCT03755323", "title": "Establishment of a Database of Patients Suffering From Obesity With a Medical Treatment", "status": "UNKNOWN", "phases": [], "sponsor": "University Hospital, Montpellier", "sponsorKey": "university hospital, montpellier", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "BMI Greater Than 30" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2018-09-01", "primaryCompletionDate": "2022-12-31", "lastUpdateDate": "2020-03-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03755323" }, { "nctId": "NCT01057277", "title": "RAD001, Cisplatin and Concurrent Radiation for Locally Advanced, Inoperable Head and Neck Cancer", "status": "TERMINATED", "phases": [ "PHASE1" ], "sponsor": "howard safran", "sponsorKey": "howard safran", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Head and Neck Cancer" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2009-12", "primaryCompletionDate": "2011-05", "lastUpdateDate": "2020-02-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01057277" }, { "nctId": "NCT03816020", "title": "NAD-supplementation in Drug naïve Parkinson's Disease", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Haukeland University Hospital", "sponsorKey": "haukeland university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Parkinson Disease", "Neurodegenerative Diseases" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-03-09", "primaryCompletionDate": "2020-02-10", "lastUpdateDate": "2020-02-12", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03816020" }, { "nctId": "NCT01804049", "title": "Metformin and Muscle in Insulin-resistant Older Veterans", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "VA Office of Research and Development", "sponsorKey": "va office of research and development", "sponsorType": "government", "sponsorClass": "FED", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Prediabetes" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2014-04-08", "primaryCompletionDate": "2018-08-31", "lastUpdateDate": "2020-02-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01804049" }, { "nctId": "NCT03796182", "title": "Study of PF 04965842 Effect on MATE1/2K Activity in Healthy Participants", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Pfizer", "sponsorKey": "pfizer", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "PFE", "tickerCompany": "Pfizer Inc", "listingStatus": "ticker", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2019-01-10", "primaryCompletionDate": "2019-02-13", "lastUpdateDate": "2020-02-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03796182" }, { "nctId": "NCT03635411", "title": "Basis: Evaluating Sirtuin Supplements To Benefit Elderly Trauma Patients (BES2T BET)", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Elysium Health", "sponsorKey": "elysium health", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Recovery of Function" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-12-06", "primaryCompletionDate": "2020-11", "lastUpdateDate": "2020-01-06", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03635411" }, { "nctId": "NCT03951285", "title": "Nicotinamide Riboside and Mitochondrial Metabolism", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Helsinki University Central Hospital", "sponsorKey": "helsinki university central hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-05-25", "primaryCompletionDate": "2019-05-31", "lastUpdateDate": "2019-12-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03951285" }, { "nctId": "NCT04133649", "title": "Evaluation of Safety and Tolerability of Libella Gene Therapy for the Treatment of Aging: AAV- hTERT", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Libella Gene Therapeutics", "sponsorKey": "libella gene therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Aging" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2019-10-17", "primaryCompletionDate": "2021-01", "lastUpdateDate": "2019-12-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04133649" }, { "nctId": "NCT03665350", "title": "Insulin Treatment in Diabetic Older People With Heart Failure.", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Mario Negri Institute for Pharmacological Research", "sponsorKey": "mario negri institute for pharmacological research", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure", "Diabetes Mellitus, Type 2" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2018-11-08", "primaryCompletionDate": "2019-09-18", "lastUpdateDate": "2019-11-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03665350" }, { "nctId": "NCT04110964", "title": "Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Libella Gene Therapeutics", "sponsorKey": "libella gene therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Critical Limb Ischemia" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2019-09-26", "primaryCompletionDate": "2020-12", "lastUpdateDate": "2019-10-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04110964" }, { "nctId": "NCT04133454", "title": "Evaluation of Safety and Tolerability of Libella Gene Therapy for Alzheimer's Disease: AAV- hTERT", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Libella Gene Therapeutics", "sponsorKey": "libella gene therapeutics", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Alzheimer Disease" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2019-10-10", "primaryCompletionDate": "2021-01", "lastUpdateDate": "2019-10-28", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04133454" }, { "nctId": "NCT01847261", "title": "Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "DuPont Nutrition and Health", "sponsorKey": "dupont nutrition and health", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Muscle Synthesis" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2013-04", "primaryCompletionDate": "2014-11", "lastUpdateDate": "2019-10-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01847261" }, { "nctId": "NCT02812238", "title": "Study to Evaluate the Effect of Nicotinamide Riboside on Immunity", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Atherosclerosis", "Diabetes", "Coronary Artery Disease" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-06-23", "primaryCompletionDate": "2018-08-28", "lastUpdateDate": "2019-09-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02812238" }, { "nctId": "NCT02308228", "title": "Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Philip Kern", "sponsorKey": "philip kern", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2015-01-14", "primaryCompletionDate": "2017-12-14", "lastUpdateDate": "2019-09-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02308228" }, { "nctId": "NCT02679989", "title": "The Impact Of An Intermittent Energy Restricted Diet On Insulin Sensitivity In Men and Women With Central Obesity", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "King's College London", "sponsorKey": "king's college london", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity, Abdominal" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-02", "primaryCompletionDate": "2016-07", "lastUpdateDate": "2019-09-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02679989" }, { "nctId": "NCT04077918", "title": "Comparison of the Effects of Different Protein Diet in Hemodialysis Patients", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Camillians Saint Mary's Hospital Luodong", "sponsorKey": "camillians saint mary's hospital luodong", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diffenence of Protein Diets on Hemodialysis Patients" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2019-10-01", "primaryCompletionDate": "2020-04-30", "lastUpdateDate": "2019-09-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04077918" }, { "nctId": "NCT03932539", "title": "Improving Immunosuppressive Therapy in Heart Transplantation", "status": "UNKNOWN", "phases": [], "sponsor": "Fondazione IRCCS Policlinico San Matteo di Pavia", "sponsorKey": "fondazione irccs policlinico san matteo di pavia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Rejection Heart Transplant", "Immunosuppression" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2019-05-14", "primaryCompletionDate": "2020-12", "lastUpdateDate": "2019-08-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03932539" }, { "nctId": "NCT02881697", "title": "mTOR and Adipose Tissue Inflammation", "status": "COMPLETED", "phases": [], "sponsor": "University Hospital, Basel, Switzerland", "sponsorKey": "university hospital, basel, switzerland", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2016-09-27", "primaryCompletionDate": "2019-04-23", "lastUpdateDate": "2019-08-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02881697" }, { "nctId": "NCT01561053", "title": "A Study to Evaluate Albumin and Immunoglobulin in Alzheimer's Disease", "status": "COMPLETED", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Instituto Grifols", "sponsorKey": "instituto grifols", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Alzheimer's Disease" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2012-04-19", "primaryCompletionDate": "2018-03-06", "lastUpdateDate": "2019-07-31", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01561053" }, { "nctId": "NCT03562468", "title": "A Study by ChromaDex to Assess the Effects of TRU NIAGEN on Cognitive Function, Mood and Sleep in Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "ChromaDex", "sponsorKey": "chromadex", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "CDXC", "tickerCompany": "ChromaDex Corp", "listingStatus": "ticker", "conditions": [ "Cognitive Function", "Mood", "Sleep" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-06-13", "primaryCompletionDate": "2019-04-26", "lastUpdateDate": "2019-07-24", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03562468" }, { "nctId": "NCT00723255", "title": "Bevacizumab and Temsirolimus in Treating Patients With Recurrent or Persistent Endometrial Cancer", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "National Cancer Institute (NCI)", "sponsorKey": "national cancer institute (nci)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Recurrent Endometrial Carcinoma" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2008-09", "primaryCompletionDate": "2011-07-15", "lastUpdateDate": "2019-07-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00723255" }, { "nctId": "NCT03509818", "title": "Effects of the Physical Fitness on Serum Klotho Levels in Healthy Population", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universidad Europea de Madrid", "sponsorKey": "universidad europea de madrid", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Population" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-03-21", "primaryCompletionDate": "2018-10-30", "lastUpdateDate": "2019-07-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03509818" }, { "nctId": "NCT04008225", "title": "Study of the Effects of Bronchoalveolar Lavage Liquid in the ARDS on the Functioning of the Neutrophil Polynuclear System", "status": "COMPLETED", "phases": [], "sponsor": "Rennes University Hospital", "sponsorKey": "rennes university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "ARDS, Human" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2015-05-05", "primaryCompletionDate": "2016-05-05", "lastUpdateDate": "2019-07-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT04008225" }, { "nctId": "NCT03176628", "title": "Pharmacokinetics, Pharmacodynamics and Safety of Basis in Acute Kidney Injury Study", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Massachusetts General Hospital", "sponsorKey": "massachusetts general hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Acute Kidney Injury" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2017-11-01", "primaryCompletionDate": "2018-09-11", "lastUpdateDate": "2019-06-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03176628" }, { "nctId": "NCT00123110", "title": "Insulin Resistance and Testosterone in Women", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "University of Pennsylvania", "sponsorKey": "university of pennsylvania", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance", "Postmenopause" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2005-07", "primaryCompletionDate": "2011-12", "lastUpdateDate": "2019-05-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00123110" }, { "nctId": "NCT03061409", "title": "Vitamin and Mineral Supplementation Improves Micronutrient Status in Older Adults", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Tufts University", "sponsorKey": "tufts university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Nutrient Deficiency" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-05-01", "primaryCompletionDate": "2019-03-15", "lastUpdateDate": "2019-05-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03061409" }, { "nctId": "NCT03072485", "title": "Phase 1 Study of the Effects of Combining Topical FDA-approved Drugs on Age-related Pathways on the Skin of Healthy Volunteers", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Anne Chang", "sponsorKey": "anne chang", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin", "Metformin / TAME" ], "topicKeys": [ "rapamycin", "metformin" ], "startDate": "2017-03-01", "primaryCompletionDate": "2019-02-22", "lastUpdateDate": "2019-04-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03072485" }, { "nctId": "NCT02422108", "title": "TNFSF11 Inhibition and Fertility: a Prospective Study", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Martin Blomberg Jensen", "sponsorKey": "martin blomberg jensen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Testis", "Infertility", "Sperm" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-05", "primaryCompletionDate": "2017-02", "lastUpdateDate": "2019-03-27", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02422108" }, { "nctId": "NCT02437578", "title": "Clinical Tests to Predict the Success of Assisted Reproductive Techniques", "status": "COMPLETED", "phases": [], "sponsor": "Martin Blomberg Jensen", "sponsorKey": "martin blomberg jensen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Infertility" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-05", "primaryCompletionDate": "2018-10", "lastUpdateDate": "2019-03-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02437578" }, { "nctId": "NCT02336932", "title": "Vitamin D and the Free Hormone Hypothesis", "status": "COMPLETED", "phases": [], "sponsor": "Rigshospitalet, Denmark", "sponsorKey": "rigshospitalet, denmark", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Arthrosis", "Surgery" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-02", "primaryCompletionDate": "2017-02", "lastUpdateDate": "2019-03-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02336932" }, { "nctId": "NCT02835664", "title": "Nicotinamide Riboside and Metabolic Health", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Maastricht University Medical Center", "sponsorKey": "maastricht university medical center", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Insulin Resistance" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-12", "primaryCompletionDate": "2018-12", "lastUpdateDate": "2019-03-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02835664" }, { "nctId": "NCT01922167", "title": "Resistance Exercise Training and Amino Acid Leucine Supplementation in Frail Elderly Women", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "McGill University Health Centre/Research Institute of the McGill University Health Centre", "sponsorKey": "mcgill university health centre/research institute of the mcgill university health centre", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Frail Elderly" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2013-11", "primaryCompletionDate": "2018-02-08", "lastUpdateDate": "2019-03-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01922167" }, { "nctId": "NCT03858413", "title": "a-Klotho in Relation to Calcification in the Coronary Arteries and Aortic Valve in Patients With Chronic Kidney Disease", "status": "COMPLETED", "phases": [], "sponsor": "Royal Brompton & Harefield NHS Foundation Trust", "sponsorKey": "royal brompton & harefield nhs foundation trust", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vascular Calcification", "Chronic Kidney Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-01-15", "primaryCompletionDate": "2018-12-31", "lastUpdateDate": "2019-02-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03858413" }, { "nctId": "NCT03838822", "title": "Kinetics of Metabolic Cofactors in NAFLD", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Sahlgrenska University Hospital", "sponsorKey": "sahlgrenska university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2018-09-01", "primaryCompletionDate": "2018-11-01", "lastUpdateDate": "2019-02-15", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03838822" }, { "nctId": "NCT02874924", "title": "Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the Elderly", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "The University of Texas Health Science Center at San Antonio", "sponsorKey": "the university of texas health science center at san antonio", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2016-06", "primaryCompletionDate": "2018-09", "lastUpdateDate": "2018-12-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02874924" }, { "nctId": "NCT03743675", "title": "Influence of Aerobic Training and Weight Loss on Skeletal Muscle Inflammatory Markers and Muscle Protein Balance in Older Adults", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Miami University", "sponsorKey": "miami university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight and Obesity", "Inflammation; Muscle", "Sedentary Lifestyle" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2018-01-31", "primaryCompletionDate": "2021-07-30", "lastUpdateDate": "2018-11-16", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03743675" }, { "nctId": "NCT01714102", "title": "Resveratrol and the Metabolic Syndrome", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Rockefeller University", "sponsorKey": "rockefeller university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Insulin Resistance", "Metabolic Syndrome" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2012-10", "primaryCompletionDate": "2015-08", "lastUpdateDate": "2018-10-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01714102" }, { "nctId": "NCT03707756", "title": "Systematic Review of Phenotypical Characteristics of P51S COCH Mutation", "status": "WITHDRAWN", "phases": [], "sponsor": "Jessa Hospital", "sponsorKey": "jessa hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "DFNA9" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2018-05-01", "primaryCompletionDate": "2018-09-30", "lastUpdateDate": "2018-10-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03707756" }, { "nctId": "NCT03334357", "title": "Physical Fitness as Klotho Protein Stimulator.", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Manuel Castillo Garzón", "sponsorKey": "manuel castillo garzón", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Physical Activity", "Aging" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-06-01", "primaryCompletionDate": "2017-12-23", "lastUpdateDate": "2018-10-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03334357" }, { "nctId": "NCT02773823", "title": "A Behavior Intervention Study on Cardiovascular Health Among Chinese Obese Schoolchildren", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Wuhan University", "sponsorKey": "wuhan university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Cardiovascular Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-11", "primaryCompletionDate": "2016-06", "lastUpdateDate": "2018-10-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02773823" }, { "nctId": "NCT01024998", "title": "Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD)", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Genzyme, a Sanofi", "sponsorKey": "genzyme, a sanofi", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "SNY", "tickerCompany": "Sanofi SA (Genzyme)", "listingStatus": "ticker", "conditions": [ "Macular Degeneration", "Age-Related Maculopathies", "Age-Related Maculopathy", "Maculopathies, Age-Related", "Maculopathy, Age-Related", "Retinal Degeneration", "Retinal Neovascularization", "Gene Therapy", "Therapy, Gene", "Eye Diseases" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2010-01-11", "primaryCompletionDate": "2014-07", "lastUpdateDate": "2018-08-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01024998" }, { "nctId": "NCT02751099", "title": "Bone and Cardiovascular Disease After Kidney Transplant", "status": "UNKNOWN", "phases": [], "sponsor": "Centro Hospitalar de Lisboa Central", "sponsorKey": "centro hospitalar de lisboa central", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Renal Insufficiency", "Disorder Related to Renal Transplantation", "Metabolic Bone Diseases", "Vascular Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-11", "primaryCompletionDate": "2018-10", "lastUpdateDate": "2018-08-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02751099" }, { "nctId": "NCT02167620", "title": "Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Centre for Addiction and Mental Health", "sponsorKey": "centre for addiction and mental health", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Type 2", "Schizophrenia" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2014-06", "primaryCompletionDate": "2018-02", "lastUpdateDate": "2018-07-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02167620" }, { "nctId": "NCT03308747", "title": "Inflammaging and Muscle Protein Metabolism", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Thessaly", "sponsorKey": "university of thessaly", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Inflammaging", "Sarcopenia" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2017-09-01", "primaryCompletionDate": "2018-02-15", "lastUpdateDate": "2018-07-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03308747" }, { "nctId": "NCT03585777", "title": "Compare Serum Klotho Levels in Patients on Oral Antidiabetic Treatment", "status": "UNKNOWN", "phases": [], "sponsor": "Fayoum University", "sponsorKey": "fayoum university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Compare Serum Level of Klotho in Patients on Oral Antidiabetic Treatment" ], "topics": [ "Metformin / TAME", "Klotho" ], "topicKeys": [ "metformin", "klotho" ], "startDate": "2018-10-11", "primaryCompletionDate": "2019-01", "lastUpdateDate": "2018-07-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03585777" }, { "nctId": "NCT03579537", "title": "Effects of Exercise on Physical Fitness Among Hemodialysis Patients With Chronic Kidney Disease", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universidad Politecnica de Madrid", "sponsorKey": "universidad politecnica de madrid", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hemolysis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-07-22", "primaryCompletionDate": "2015-07-15", "lastUpdateDate": "2018-07-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03579537" }, { "nctId": "NCT03532568", "title": "Klotho in Chronic Kidney Disease-associated Pruritis (CKD-aP)", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Cairo University", "sponsorKey": "cairo university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease-associated Pruritus" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2018-05", "primaryCompletionDate": "2018-12", "lastUpdateDate": "2018-05-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03532568" }, { "nctId": "NCT02370745", "title": "Characterizing the Incretin Effect of Amino Acids and Defining GLP-1 Role on Skeletal Muscle", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Nottingham", "sponsorKey": "university of nottingham", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2014-11", "primaryCompletionDate": "2018-03", "lastUpdateDate": "2018-05-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02370745" }, { "nctId": "NCT02712593", "title": "A Study Investigating the Effects of Niagen™ in Healthy Adults.", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "KGK Science", "sponsorKey": "kgk science", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Bioavailability" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-03-21", "primaryCompletionDate": "2017-03-17", "lastUpdateDate": "2018-04-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02712593" }, { "nctId": "NCT02445560", "title": "The Effects of a High Protein Diet on Microbiota, Gastrointestinal Function and Wellness in Older Women", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Florida", "sponsorKey": "university of florida", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2015-06", "primaryCompletionDate": "2015-10", "lastUpdateDate": "2018-03-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02445560" }, { "nctId": "NCT00004992", "title": "Diabetes Prevention Program", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "sponsorKey": "national institute of diabetes and digestive and kidney diseases (niddk)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Non-Insulin-Dependent", "Glucose Intolerance" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "1996-07", "primaryCompletionDate": "2001-04", "lastUpdateDate": "2018-03-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00004992" }, { "nctId": "NCT02951442", "title": "Identification of Markers (Klotho-FGF23 Axis) as Determinant in the Evolution of Arterial Stiffness During the First Year of Renal Transplant", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Hopital Foch", "sponsorKey": "hopital foch", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Transplant" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2011-01", "primaryCompletionDate": "2014-01-28", "lastUpdateDate": "2018-02-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02951442" }, { "nctId": "NCT02732899", "title": "Sirolimus in Conjunction With Eylea vs Eylea Alone for Exudative AMD", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Maturi, Raj K., M.D., P.C", "sponsorKey": "maturi, raj k., m.d., p.c", "sponsorType": "academic", "sponsorClass": "INDIV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Exudative Age Related Macular Degeneration" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2016-04", "primaryCompletionDate": "2017-03-20", "lastUpdateDate": "2018-02-14", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02732899" }, { "nctId": "NCT02689882", "title": "\"Pharmacokinetic Study of Nicotinamide Riboside\"", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "University of Washington", "sponsorKey": "university of washington", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Metabolic Disturbance" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2015-11", "primaryCompletionDate": "2015-12", "lastUpdateDate": "2018-02-08", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02689882" }, { "nctId": "NCT02140983", "title": "Effects of Liraglutide on Hippocampal Structure and Function in Aging Adults With Prediabetes", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Stanford University", "sponsorKey": "stanford university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance", "Dementia" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2013-08", "primaryCompletionDate": "2017-02", "lastUpdateDate": "2018-01-25", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02140983" }, { "nctId": "NCT03353597", "title": "Reversing Epigenetic & Other Markers of Senescence by Transfusing Young Plasma To Older Human Subjects", "status": "UNKNOWN", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Chandra Duggirala", "sponsorKey": "chandra duggirala", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Aging" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2018-05-15", "primaryCompletionDate": "2020-06-15", "lastUpdateDate": "2018-01-17", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03353597" }, { "nctId": "NCT03079518", "title": "Intravenous Iron in paTients With Heart failURe and Reduced Ejection fracTion (HFREF) pLus Iron dEficiency", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "RWTH Aachen University", "sponsorKey": "rwth aachen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure, Systolic", "Iron Deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-03-10", "primaryCompletionDate": "2017-10-25", "lastUpdateDate": "2017-12-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03079518" }, { "nctId": "NCT03307707", "title": "New Heart Failure Biomarkers in Early Stage Chronic Kidney Disease-Mineral and Bone Disorder", "status": "COMPLETED", "phases": [], "sponsor": "Pr. Semir Nouira", "sponsorKey": "pr. semir nouira", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Disease, Chronic", "Heart Failure" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2015-06-15", "primaryCompletionDate": "2015-09-30", "lastUpdateDate": "2017-10-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT03307707" }, { "nctId": "NCT02918591", "title": "Cardiovascular Effects of Empagliflozine", "status": "UNKNOWN", "phases": [ "NA" ], "sponsor": "Tel Aviv University", "sponsorKey": "tel aviv university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2017-11", "primaryCompletionDate": "2018-03", "lastUpdateDate": "2017-10-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02918591" }, { "nctId": "NCT01494805", "title": "Safety and Efficacy Study of rAAV.sFlt-1 in Patients With Exudative Age-Related Macular Degeneration", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Lions Eye Institute, Perth, Western Australia", "sponsorKey": "lions eye institute, perth, western australia", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Macular Degeneration", "Age-related Maculopathies", "Age-related Maculopathy", "Maculopathies,Age-related", "Maculopathy,Age-related", "Retinal Degeneration", "Retinal Neovascularization", "Eye Diseases" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2011-12", "primaryCompletionDate": "2017-05", "lastUpdateDate": "2017-09-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01494805" }, { "nctId": "NCT01767181", "title": "Light and Exercise in Night-shift Workers", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universitätsklinikum Hamburg-Eppendorf", "sponsorKey": "universitätsklinikum hamburg-eppendorf", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Night Shift Workers" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2013-02", "primaryCompletionDate": "2016-12", "lastUpdateDate": "2017-08-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01767181" }, { "nctId": "NCT02484209", "title": "DiaFrail: A Short Duration Study in Older People ( DIAFRAIL Study)", "status": "WITHDRAWN", "phases": [ "PHASE3" ], "sponsor": "Diabetes Frail", "sponsorKey": "diabetes frail", "sponsorType": "industry", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Diabetes Mellitus" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-02", "primaryCompletionDate": "2016-10", "lastUpdateDate": "2017-07-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02484209" }, { "nctId": "NCT01059760", "title": "Expression of Longevity Genes in Response to Extended Fasting", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Intermountain Health Care", "sponsorKey": "intermountain health care", "sponsorType": "industry", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Cardiovascular Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2010-01", "primaryCompletionDate": "2010-08", "lastUpdateDate": "2017-07-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01059760" }, { "nctId": "NCT02303483", "title": "The Effect of Vitamin B3 on Substrate Metabolism, Insulin Sensitivity, and Body Composition in Obese Men", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Aarhus University Hospital", "sponsorKey": "aarhus university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obese" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-01-04", "primaryCompletionDate": "2017-04-04", "lastUpdateDate": "2017-07-02", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02303483" }, { "nctId": "NCT00272857", "title": "Bone Marrow Cell Gene Transfer in Individuals With Fanconi Anemia", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Boston Children's Hospital", "sponsorKey": "boston children's hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Fanconi Anemia" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2004-08", "primaryCompletionDate": "2007-10", "lastUpdateDate": "2017-06-23", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00272857" }, { "nctId": "NCT02357342", "title": "Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMD", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Maturi, Raj K., M.D., P.C", "sponsorKey": "maturi, raj k., m.d., p.c", "sponsorType": "academic", "sponsorClass": "INDIV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Macular Degeneration" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2015-04", "primaryCompletionDate": "2017-01", "lastUpdateDate": "2017-06-22", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02357342" }, { "nctId": "NCT02950441", "title": "Nicotinamide Adenine Dinucleotide and Skeletal Muscle Metabolic Phenotype", "status": "UNKNOWN", "phases": [ "PHASE2" ], "sponsor": "University of Birmingham", "sponsorKey": "university of birmingham", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-06", "primaryCompletionDate": "2018-09", "lastUpdateDate": "2017-06-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02950441" }, { "nctId": "NCT00891696", "title": "Nutritional and Contractile Regulation of Muscle Growth", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "The University of Texas Medical Branch, Galveston", "sponsorKey": "the university of texas medical branch, galveston", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Sarcopenia" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2009-04", "primaryCompletionDate": "2015-03", "lastUpdateDate": "2017-05-04", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00891696" }, { "nctId": "NCT01301443", "title": "Phase I Dose Escalation Safety Study of RetinoStat in Advanced Age-Related Macular Degeneration (AMD)", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Oxford BioMedica", "sponsorKey": "oxford biomedica", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "OXB.L", "tickerCompany": "Oxford Biomedica plc", "listingStatus": "ticker", "conditions": [ "Age Related Macular Degeneration" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": "2011-02", "primaryCompletionDate": "2014-09", "lastUpdateDate": "2017-04-05", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01301443" }, { "nctId": "NCT02126293", "title": "Correction of Zinc Deficiency in Children With Chronic Kidney Disease and Kidney Transplant", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Hamilton Health Sciences", "sponsorKey": "hamilton health sciences", "sponsorType": "industry", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Renal Insufficiency, Chronic", "Zinc Deficiency", "Trace Element Excess", "Trace Element Deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-09", "primaryCompletionDate": "2017-01", "lastUpdateDate": "2017-03-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02126293" }, { "nctId": "NCT01686568", "title": "Omega-3 Fatty Acids and Insulin Sensitivity", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance" ], "topics": [ "Senolytics" ], "topicKeys": [ "senolytics" ], "startDate": "2012-12-21", "primaryCompletionDate": "2014-10-30", "lastUpdateDate": "2017-03-03", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01686568" }, { "nctId": "NCT00105066", "title": "The Effects of Metformin on Blood Vessel Structure and Function", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "National Institute on Aging (NIA)", "sponsorKey": "national institute on aging (nia)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity", "Hypertension", "Hypercholesterolemia", "Hyperglycemia" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2004-01", "primaryCompletionDate": "2008-05", "lastUpdateDate": "2017-01-18", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00105066" }, { "nctId": "NCT01649960", "title": "Exercise and Low-Dose Rapamycin in Older Adults With CAD:Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Mayo Clinic", "sponsorKey": "mayo clinic", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "CAD" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2012-08", "primaryCompletionDate": "2015-12", "lastUpdateDate": "2016-12-07", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01649960" }, { "nctId": "NCT02921659", "title": "Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults", "status": "COMPLETED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "University of Colorado, Boulder", "sponsorKey": "university of colorado, boulder", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2015-04", "primaryCompletionDate": "2016-10", "lastUpdateDate": "2016-12-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02921659" }, { "nctId": "NCT00304954", "title": "Infliximab, Sirolimus and Daclizumab to Treat Age-Related Macular Degeneration", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "National Eye Institute (NEI)", "sponsorKey": "national eye institute (nei)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age-Related Macular Degeneration", "Choroidal Neovascularization" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2006-02", "primaryCompletionDate": "2010-01", "lastUpdateDate": "2016-11-29", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00304954" }, { "nctId": "NCT02976688", "title": "Effects of Short-chain Fatty Acids on Inflammatory and Metabolic Parameters in Maintenance Hemodialysis", "status": "UNKNOWN", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Azienda Sanitaria ASL Avellino 2", "sponsorKey": "azienda sanitaria asl avellino 2", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Endstage Renal Disease" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2017-01", "primaryCompletionDate": "2017-07", "lastUpdateDate": "2016-11-29", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02976688" }, { "nctId": "NCT00000620", "title": "Action to Control Cardiovascular Risk in Diabetes (ACCORD)", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsorKey": "national heart, lung, and blood institute (nhlbi)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Atherosclerosis", "Cardiovascular Diseases", "Hypercholesterolemia", "Hypertension", "Diabetes Mellitus, Type 2", "Diabetes Mellitus", "Coronary Disease" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "1999-09", "primaryCompletionDate": "2009-06", "lastUpdateDate": "2016-11-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00000620" }, { "nctId": "NCT02913183", "title": "Efficacy and Safety of Young Health Plasma on Acute Stroke", "status": "UNKNOWN", "phases": [ "PHASE2" ], "sponsor": "Xinqiao Hospital of Chongqing", "sponsorKey": "xinqiao hospital of chongqing", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Stroke" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2016-10", "primaryCompletionDate": "2017-10", "lastUpdateDate": "2016-09-23", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02913183" }, { "nctId": "NCT02325245", "title": "Effects of Metformin in Pre-frail Elderly", "status": "UNKNOWN", "phases": [ "PHASE3" ], "sponsor": "Indonesia University", "sponsorKey": "indonesia university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Pre-frail Elderly" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2015-03", "primaryCompletionDate": "2016-12", "lastUpdateDate": "2016-09-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02325245" }, { "nctId": "NCT02894112", "title": "Effects of Fluid Milk in Attenuating Hyperglycemia and Hypertriglyceridemia After Meal", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Texas at Austin", "sponsorKey": "university of texas at austin", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Oral Glucose Tolerance Test", "High Fat Tolerance Test" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2013-04", "primaryCompletionDate": "2015-12", "lastUpdateDate": "2016-09-09", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02894112" }, { "nctId": "NCT02678611", "title": "A Study to Evaluate Safety and Health Benefits of Basis™ Among Elderly Subjects.", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "Elysium Health", "sponsorKey": "elysium health", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Safety: Healthy Subjects" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2016-01", "primaryCompletionDate": "2016-07", "lastUpdateDate": "2016-08-01", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02678611" }, { "nctId": "NCT01660308", "title": "Observing the Changes of Fibroblast Growth Factor 23 in Patients of Tumor Induced Osteomalacia", "status": "UNKNOWN", "phases": [], "sponsor": "National Taiwan University Hospital", "sponsorKey": "national taiwan university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypophosphatemia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2011-06", "primaryCompletionDate": "2016-08", "lastUpdateDate": "2016-07-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01660308" }, { "nctId": "NCT00742417", "title": "Efficacy and Safety of Plasma Exchange With 5% Albumin in Beta-amyloid Peptide Clearance in Cerebral Spinal Fluid", "status": "COMPLETED", "phases": [ "PHASE2" ], "sponsor": "Instituto Grifols", "sponsorKey": "instituto grifols", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Alzheimer's Disease" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2007-07", "primaryCompletionDate": "2011-02", "lastUpdateDate": "2016-06-14", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00742417" }, { "nctId": "NCT01304927", "title": "Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial", "status": "COMPLETED", "phases": [ "PHASE2", "PHASE3" ], "sponsor": "Rigshospitalet, Denmark", "sponsorKey": "rigshospitalet, denmark", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Male Infertility" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2011-02", "primaryCompletionDate": "2014-12", "lastUpdateDate": "2016-06-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01304927" }, { "nctId": "NCT01943396", "title": "Treatment of AMD With Rheohemapheresis /RHF/", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "University Hospital Hradec Kralove", "sponsorKey": "university hospital hradec kralove", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Age Related Macular Degeneration" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2013-09", "primaryCompletionDate": "2016-05", "lastUpdateDate": "2016-06-01", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01943396" }, { "nctId": "NCT01597024", "title": "Full4Health: Understanding Food-gut-brain Axis Across the Lifecourse", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "University of Aberdeen", "sponsorKey": "university of aberdeen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Obesity" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2012-05", "primaryCompletionDate": "2015-08", "lastUpdateDate": "2016-05-20", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01597024" }, { "nctId": "NCT02745886", "title": "Metformin Induces a Dietary Restriction-like State in Human", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "Xiang Guang-da", "sponsorKey": "xiang guang-da", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Overweight Subjects", "Metformin", "Aging" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2016-04", "primaryCompletionDate": "2016-12", "lastUpdateDate": "2016-04-26", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02745886" }, { "nctId": "NCT02696005", "title": "Hormone KLOTHO Level in Heart Failure Patients That Participate in Rehabilitation Programme", "status": "UNKNOWN", "phases": [], "sponsor": "Bnai Zion Medical Center", "sponsorKey": "bnai zion medical center", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Heart Failure" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2016-03", "primaryCompletionDate": "2017-03", "lastUpdateDate": "2016-03-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02696005" }, { "nctId": "NCT02650336", "title": "Aging Biomakers and ConTrast Induced Nephropathy (ACTIN) Trial", "status": "COMPLETED", "phases": [], "sponsor": "Sun Yat-sen University", "sponsorKey": "sun yat-sen university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Contrast Induced Nephropathy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2013-10", "primaryCompletionDate": "2015-09", "lastUpdateDate": "2016-01-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02650336" }, { "nctId": "NCT01675947", "title": "Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "National Eye Institute (NEI)", "sponsorKey": "national eye institute (nei)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Geographic Atrophy" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2012-02", "primaryCompletionDate": "2015-06", "lastUpdateDate": "2015-12-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01675947" }, { "nctId": "NCT00707759", "title": "Steroid Withdrawal in Pediatric Renal Transplant: Impact on Growth, Bone Metabolism and Acute Rejection", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "Fondo Nacional de Desarrollo Científico y Tecnológico, Chile", "sponsorKey": "fondo nacional de desarrollo científico y tecnológico, chile", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Diseases" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2008-06", "primaryCompletionDate": "2012-12", "lastUpdateDate": "2015-11-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00707759" }, { "nctId": "NCT02518932", "title": "The Effect of VTC-G15 (a Pentapeptide Cleavage Product og GLP-1) on Whole Body Glucose Metabolism in Man", "status": "UNKNOWN", "phases": [ "PHASE1" ], "sponsor": "Elahi, Dariush, PhD", "sponsorKey": "elahi, dariush, phd", "sponsorType": "academic", "sponsorClass": "INDIV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2015-03", "primaryCompletionDate": "2016-03", "lastUpdateDate": "2015-08-10", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02518932" }, { "nctId": "NCT02511665", "title": "Metformin And Longevity", "status": "UNKNOWN", "phases": [ "PHASE4" ], "sponsor": "Guy's and St Thomas' NHS Foundation Trust", "sponsorKey": "guy's and st thomas' nhs foundation trust", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Prostate Cancer" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2015-07", "primaryCompletionDate": "2017-07", "lastUpdateDate": "2015-07-30", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02511665" }, { "nctId": "NCT02022475", "title": "Effect of Vitamin D Treatment on Fatigue", "status": "COMPLETED", "phases": [ "PHASE3" ], "sponsor": "University of Zurich", "sponsorKey": "university of zurich", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Vitamin D Deficiency" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2013-12", "primaryCompletionDate": "2015-05", "lastUpdateDate": "2015-07-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02022475" }, { "nctId": "NCT01902394", "title": "The Addition of Whole Grains to the Diets of Adults: A Study of Digestive Health and Natural Defenses", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Tufts University", "sponsorKey": "tufts university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Digestive Health and Immune Function" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2012-06", "primaryCompletionDate": "2014-09", "lastUpdateDate": "2015-05-21", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01902394" }, { "nctId": "NCT02300740", "title": "Pharmacokinetic Analysis of Nicotinamide Riboside", "status": "COMPLETED", "phases": [ "EARLY_PHASE1" ], "sponsor": "Aarhus University Hospital", "sponsorKey": "aarhus university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy Participants" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2014-12", "primaryCompletionDate": "2015-02", "lastUpdateDate": "2015-02-27", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02300740" }, { "nctId": "NCT02331966", "title": "Molecular Pathways Involved in the Pathogenesis and Behavior of Mesenchymal Phosphaturic Tumors Causing Oncogenic Osteomalacia", "status": "UNKNOWN", "phases": [], "sponsor": "AHEPA University Hospital", "sponsorKey": "ahepa university hospital", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Tumor Induced Oncogenic Osteomalacia" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2014-09", "primaryCompletionDate": "2016-12", "lastUpdateDate": "2015-01-06", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02331966" }, { "nctId": "NCT02240043", "title": "Growth Hormone Evaluation in the Elderly People", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Universidade Federal do Rio de Janeiro", "sponsorKey": "universidade federal do rio de janeiro", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2011-09", "primaryCompletionDate": "2013-08", "lastUpdateDate": "2014-09-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02240043" }, { "nctId": "NCT02191462", "title": "A Study of the Pharmacokinetics of Three Dosages of Niagen in Healthy Subjects", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "KGK Science", "sponsorKey": "kgk science", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "privat", "conditions": [ "Pharmacokinetics" ], "topics": [ "NAD+/NMN" ], "topicKeys": [ "nad_nmn" ], "startDate": "2014-07", "primaryCompletionDate": "2014-08", "lastUpdateDate": "2014-09-09", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT02191462" }, { "nctId": "NCT01728012", "title": "Long-term Cardiovascular Risk Following Successful Renal Transplantation", "status": "COMPLETED", "phases": [], "sponsor": "Helse Stavanger HF", "sponsorKey": "helse stavanger hf", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Renal Transplant" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2012-11", "primaryCompletionDate": "2013-10", "lastUpdateDate": "2014-08-15", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01728012" }, { "nctId": "NCT01698502", "title": "Physical Training and the Incretin Effect", "status": "COMPLETED", "phases": [], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Healthy" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2012-08", "primaryCompletionDate": "2013-02", "lastUpdateDate": "2014-04-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01698502" }, { "nctId": "NCT01765894", "title": "Influence of Moderate Exercise on Blood Glucose in Type 2 Diabetics and Healthy Controls", "status": "COMPLETED", "phases": [], "sponsor": "University of Copenhagen", "sponsorKey": "university of copenhagen", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes and Exercise" ], "topics": [ "Metformin / TAME", "GLP-1 & aging" ], "topicKeys": [ "metformin", "glp1_aging" ], "startDate": "2012-10", "primaryCompletionDate": "2013-11", "lastUpdateDate": "2014-02-24", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01765894" }, { "nctId": "NCT00239707", "title": "GIP: Glucose-dependent Insulinotropic Peptide", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "National Institute on Aging (NIA)", "sponsorKey": "national institute on aging (nia)", "sponsorType": "government", "sponsorClass": "NIH", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2003-02", "primaryCompletionDate": "2006-12", "lastUpdateDate": "2013-11-28", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00239707" }, { "nctId": "NCT00843479", "title": "The Aging Endocrine Pancreas: Characterization of the Entero-insular Axis Physiology in the Elderly", "status": "COMPLETED", "phases": [], "sponsor": "University of Campinas, Brazil", "sponsorKey": "university of campinas, brazil", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Type 2", "Insulin Resistance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2009-06", "primaryCompletionDate": "2010-09", "lastUpdateDate": "2013-04-22", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00843479" }, { "nctId": "NCT01765946", "title": "Metformin and Longevity Genes in Prediabetes", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "University of Padova", "sponsorKey": "university of padova", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Insulin Resistance", "Prediabetes", "Aging", "Inflammation" ], "topics": [ "Metformin / TAME" ], "topicKeys": [ "metformin" ], "startDate": "2010-06", "primaryCompletionDate": "2013-03", "lastUpdateDate": "2013-03-13", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01765946" }, { "nctId": "NCT00712491", "title": "Phase 1/2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Patients With Age-Related Macular Degeneration", "status": "TERMINATED", "phases": [ "PHASE1", "PHASE2" ], "sponsor": "Santen", "sponsorKey": "santen", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "4536.T", "tickerCompany": "Santen Pharmaceutical Co Ltd", "listingStatus": "ticker", "conditions": [ "Age-related Macular Degeneration", "Choroidal Neovascularization" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2008-09", "primaryCompletionDate": "2009-11", "lastUpdateDate": "2013-01-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00712491" }, { "nctId": "NCT00766337", "title": "Phase 2 Study of an Ocular Sirolimus (Rapamycin) Formulation in Combination With Lucentis® in Patients With Age-Related Macular Degeneration", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Santen", "sponsorKey": "santen", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "4536.T", "tickerCompany": "Santen Pharmaceutical Co Ltd", "listingStatus": "ticker", "conditions": [ "Age-Related Macular Degeneration", "Choroidal Neovascularization" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2008-12", "primaryCompletionDate": "2009-11", "lastUpdateDate": "2013-01-10", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00766337" }, { "nctId": "NCT01349374", "title": "Skin Samples of Diabetic Patients and Healthy Volunteers Collection", "status": "TERMINATED", "phases": [ "NA" ], "sponsor": "Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète", "sponsorKey": "centre d'etudes et de recherche pour l'intensification du traitement du diabète", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Type 2 Diabetes" ], "topics": [ "Partial reprogramming" ], "topicKeys": [ "reprogramming" ], "startDate": "2011-01", "primaryCompletionDate": "2011-09", "lastUpdateDate": "2012-07-12", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01349374" }, { "nctId": "NCT01526304", "title": "The Role Of FGF23, Klotho, And Sclerostin In Kidney Stone Formers", "status": "UNKNOWN", "phases": [], "sponsor": "University of Zurich", "sponsorKey": "university of zurich", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Kidney Stones" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2012-01", "primaryCompletionDate": null, "lastUpdateDate": "2012-02-03", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01526304" }, { "nctId": "NCT01524874", "title": "Comparative Effectiveness of Vitamin D and Repletion Strategies", "status": "COMPLETED", "phases": [ "NA" ], "sponsor": "Bastyr University", "sponsorKey": "bastyr university", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Hypovitaminosis D", "Insulin Resistance", "Diabetes" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2010-08", "primaryCompletionDate": "2011-09", "lastUpdateDate": "2012-02-02", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01524874" }, { "nctId": "NCT00857259", "title": "The Efficacy of Oral Everolimus in Patients With Neovascular Age-related Macular Degeneration", "status": "TERMINATED", "phases": [ "PHASE2" ], "sponsor": "Novartis Pharmaceuticals", "sponsorKey": "novartis pharmaceuticals", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": "NVS", "tickerCompany": "Novartis AG", "listingStatus": "ticker", "conditions": [ "Choroidal Neo-Vascular Age-onset Macular Degeneration", "Age-related Macular Degeneration" ], "topics": [ "Rapamycin" ], "topicKeys": [ "rapamycin" ], "startDate": "2009-02", "primaryCompletionDate": "2010-07", "lastUpdateDate": "2011-08-19", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00857259" }, { "nctId": "NCT00554112", "title": "Regulation of B-Cell Function & Glucose Tolerance in Older People", "status": "TERMINATED", "phases": [ "NA" ], "sponsor": "US Department of Veterans Affairs", "sponsorKey": "us department of veterans affairs", "sponsorType": "government", "sponsorClass": "FED", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Aging", "Glucose Intolerance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2007-11", "primaryCompletionDate": "2011-08", "lastUpdateDate": "2011-08-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00554112" }, { "nctId": "NCT01317173", "title": "Factors Related to the Progression of Chronic Kidney Disease", "status": "UNKNOWN", "phases": [], "sponsor": "Ankara Education and Research Hospital", "sponsorKey": "ankara education and research hospital", "sponsorType": "government", "sponsorClass": "OTHER_GOV", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2008-03", "primaryCompletionDate": "2011-05", "lastUpdateDate": "2011-03-17", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT01317173" }, { "nctId": "NCT00843232", "title": "Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old", "status": "COMPLETED", "phases": [], "sponsor": "University of Campinas, Brazil", "sponsorKey": "university of campinas, brazil", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Diabetes Mellitus, Type 2", "Insulin Resistance" ], "topics": [ "GLP-1 & aging" ], "topicKeys": [ "glp1_aging" ], "startDate": "2009-07", "primaryCompletionDate": "2010-09", "lastUpdateDate": "2011-02-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00843232" }, { "nctId": "NCT00017940", "title": "Gene Therapy for Alzheimer's Disease Clinical Trial", "status": "COMPLETED", "phases": [ "PHASE1" ], "sponsor": "The Shiley Family Trust", "sponsorKey": "the shiley family trust", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Alzheimer Disease" ], "topics": [ "Gene therapy (longevity)" ], "topicKeys": [ "gene_therapy" ], "startDate": null, "primaryCompletionDate": "2003-11", "lastUpdateDate": "2009-12-11", "firstSeenAt": "2026-08-03T13:13:17.497Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00017940" }, { "nctId": "NCT00858260", "title": "Arnogene: A Phosphocalcic Study in Dialysis", "status": "COMPLETED", "phases": [], "sponsor": "Hospices Civils de Lyon", "sponsorKey": "hospices civils de lyon", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Dialysis" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2008-11", "primaryCompletionDate": null, "lastUpdateDate": "2009-09-04", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00858260" }, { "nctId": "NCT00751361", "title": "Dry Age-Related Macular Degeneration (AMD) Treatment With Rheopheresis Trial", "status": "COMPLETED", "phases": [ "PHASE4" ], "sponsor": "Apheresis Research Institute", "sponsorKey": "apheresis research institute", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Dry Age Related Macular Degeneration" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "1998-11", "primaryCompletionDate": "2003-01", "lastUpdateDate": "2008-09-11", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00751361" }, { "nctId": "NCT00374712", "title": "Klotho Gene Polymorphism in Dialyzed Patients With Hyperphosphatemia", "status": "TERMINATED", "phases": [], "sponsor": "Assistance Publique - Hôpitaux de Paris", "sponsorKey": "assistance publique - hôpitaux de paris", "sponsorType": "academic", "sponsorClass": "OTHER", "ticker": null, "tickerCompany": null, "listingStatus": "non-commercial", "conditions": [ "Chronic Kidney Disease", "End Stage Renal Disease", "Hyperphosphatemia", "Renal Osteodystrophy" ], "topics": [ "Klotho" ], "topicKeys": [ "klotho" ], "startDate": "2005-01", "primaryCompletionDate": null, "lastUpdateDate": "2007-11-08", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00374712" }, { "nctId": "NCT00460967", "title": "Safety and Effectiveness Investigation for Dry, Non-Exudative Age Related Macular Degeneration (AMD) Using Rheopheresis", "status": "SUSPENDED", "phases": [ "PHASE3" ], "sponsor": "OccuLogix", "sponsorKey": "occulogix", "sponsorType": "industry", "sponsorClass": "INDUSTRY", "ticker": null, "tickerCompany": null, "listingStatus": "unmapped", "conditions": [ "Age-Related Maculopathy" ], "topics": [ "Plasma exchange" ], "topicKeys": [ "plasma_exchange" ], "startDate": "2007-01", "primaryCompletionDate": null, "lastUpdateDate": "2007-11-07", "firstSeenAt": "2026-08-11T06:43:26.743Z", "changes": [], "nctUrl": "https://clinicaltrials.gov/study/NCT00460967" } ]